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Old 09-29-2010, 11:04 PM   #1
Rich66
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New Her2 and CTC detector in development

http://www.dailytech.com/New+Microfl...ticle19751.htm


Quote:
Now, Thierry and his colleagues' device has the ability to detect the status of HER2 and help capture circulating tumor cells. The device is made of organic silicon found in most contact lenses, and polydimethylsiloxane (PDMS), which are shampoos that are transparent, permeable to gasses, and compatible with soft molding techniques. The device also contains a polymeric layer on its surface, which has a large number of reactive molecules in it. Through the use of a plasma-based polymerization process, this layer can attach to proteins that are able to catch cancer cells while leaving normal blood cells alone.
"Microfluidic-based devices offer a unique opportunity to efficiently isolate CTCs from patient's blood, thereby opening a window on the pathophysiology of cancer and its progression," said Thierry. "We hope that our device will provide a fast, reliable and affordable methodology to establish HER2 status for breast cancer patients presenting metastases, thereby enabling the selection of more potent therapy based on trastuzumab.
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Old 09-30-2010, 01:48 PM   #2
bejuce
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Re: New Her2 and CTC detector in development

Sounds promising, thanks for posting!
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ER+ (30%)/PR-/HER-2+, stage 3

Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin


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