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Old 01-30-2014, 11:05 AM   #1
Shirley
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Nuelasta v Granix

Anybody heard about changes related to Nuelasta in their clinics? There was evidently a bit of a shakeup in the Nuelasta/Nuepogen world last November, and now there is a drug called Granix that my clinic is replacing Nuelasta with (I think that was the name of it). It is much cheaper than Nuelasta, and has something to do with Nuepogen’s patent expiring and another company selling Granix to compete. I’m assuming the issue is that insurance companies may not approve Nuelasta if there is a cheaper alternative, plus I think doctor’s offices won’t risk not getting a reimbursement for it. Mine was $5000 per shot, so I can understand not wanting to take on that risk.
It sounds to me like the efficacy between the drugs might be similar, but Nuelasta is longer lasting. It therefore requires just one injection following each chemo treatment, while Nuepogen requires one injuection daily for 5-14 days, along with at least 2 blood draws to check WBC count. The Granix drug would be the same—multiple injections.
I bring it up because we often discuss this drug and I’m wondering if anyone receiving chemo lately has been told they have to have Nuepogen (generic Filgrastim) or Granix instead of Nuelasta.
Shirley
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  • Age 54 at dx (April '13) Stage 2b, grade 3
  • ER+ PR+ HER+, 9 cm tumor one breast and <0.5 cm in sentinal node
  • BRCA1 and 2 negative
  • Neoadjuvant TCH chemo started 5-15-13 (4 rounds, 3 weeks apart)
  • Unilateral Mx w/expander 8-22-13 (right side)
  • 5/5 nodes Neg
  • clear margins but close. Tumor at removal down to 2.2 cm.
  • Radiation 6 wks starting 10-17-13.
  • Herceptin every 3 weeks until 4-23-14
  • DIEP/Mastopexy 10-8-14, U of WA
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Old 01-30-2014, 02:42 PM   #2
jaykay
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Re: Nuelasta v Granix

I was told that my insurance company would NOT cover neupogen since it was primarily self-given at home. When I started chemo and found out I had to come back the day after I freaked out and asked about an alternative. That's when they told me that my insurance would not cover neupogen. My neulasta shots were about $3500 each.

Little did I realize back then that coming back the next day was one of the easier things about chemo!

Janis
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March, 2000: 48, Post menopausal (5 yrs HRT) Left breast, IDC 3mm/DCIS 1.6cm, ER+/PR-/Her2+++, mod differentiated, MIB low, lumpectomy, node neg via SNB, rads=33 Stage 1a
June, 2000: Tamox 4.5 years,Femara for 5 years (end in Jan. 2010)
Sept, 2012: 61, Via mamm, ultrasound, biopsy, right breast, 2.3cm tumor, ER+/PR-/Her2+++, poorly diff, KI67 60-70%
BRCA 1 and 2 negative
October, 2012: Bi Mast with tissue expanders, port placement
Final Path: IDC 2.8cm, DCIS, 1/4 sentinal nodes positive (@#$%). Stage IIB
Nov 29, 2012: Begin TCH/6x/every 3 wks, H for 1 year/every 3 weeks.
March 14, 2013: Finished chemo
April 9, 2013: Begin radiation 28x
May 22, 2013: Finished rads
June 1st, 2013: Started Aromasin for 5 yrs.
July 15, 2013: Switched to Letrozole (Femara). Probably for the rest of my life
October 16, 2013: Exchange surgery
October 31, 2013: Finished Herceptin
December 5, 2013: Port removed
Glad this year is over!
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Old 01-30-2014, 04:34 PM   #3
Laurel
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Re: Nuelasta v Granix

I have not heard of Granix and used Neulasta self administering at home the day following my chemo infusion. The cost was $3000/injection. It was mailed to me packed in ice and contained 2 syringes which covered a month's worth of chemo since it was infused every other week. I would not like to have to return daily for an injection. That really is not fun when you are not feeling well and seriously infringes upon your life. I am betting it is a $ issue.
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Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
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Switched back to Tamoxifen due to tendon pain from Femara

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Old 02-01-2014, 01:33 PM   #4
Adriana Mangus
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Re: Nuelasta v Granix

Hi Shirley,

Do you think this would help my situation. I just had my first Taxotere- - among manyy other treatments I have gone through in the past-- chemo on the 30th, the side effects are unbearable, body aches, dizziness, fatigue, etc.What's the criteria in order to get a shot of this injection. I have heard about it in the past, but have no idea in what circumstances is provided to cancer patients. It may help me since taxotere causes low red and blood count cells.

Thank you for your help.

Adriana
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1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--
NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.

2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.

2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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Old 02-01-2014, 04:15 PM   #5
Shirley
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Re: Nuelasta v Granix

Adriana,

Nuelasta and Nuepogen are both designed to build your white blood cell count after chemo, so they help prevent infections. I don't know why some of us receive these shots and others do not. Something tells me it is based on economics. I would ask your doctor about it if you still have more chemo treatments remaining.

Nuelasta shots are a little painful and they do have side effects like bone pain, especially in the legs and ankles.

I hope you feel improved soon.

Shirley
Go Seahawks!
__________________
  • Age 54 at dx (April '13) Stage 2b, grade 3
  • ER+ PR+ HER+, 9 cm tumor one breast and <0.5 cm in sentinal node
  • BRCA1 and 2 negative
  • Neoadjuvant TCH chemo started 5-15-13 (4 rounds, 3 weeks apart)
  • Unilateral Mx w/expander 8-22-13 (right side)
  • 5/5 nodes Neg
  • clear margins but close. Tumor at removal down to 2.2 cm.
  • Radiation 6 wks starting 10-17-13.
  • Herceptin every 3 weeks until 4-23-14
  • DIEP/Mastopexy 10-8-14, U of WA
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