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03-07-2008, 02:32 PM
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#1
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Senior Member
Join Date: Sep 2007
Location: Tampa, FL
Posts: 43
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New Study for Her2
Ladies,
I'm getting ready to start a Phase II Study using Herceptin/DM1. Anyone done this treatment or know of anyone who has? Thanks for any comments.
Hugs-Verna
__________________
stage IV, diagnosed Nov.11,2005
mets to spine,hips,pelvic,femur
4 a/c
mastectomy Feb.14,2006
4 taxol
mets to liver
5 weeks radiation
Herceptin/Zometa
reconstruction Feb.14,2007 (DEIP)
Tykerb/Xeloda
TDM1 study
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03-07-2008, 04:06 PM
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#2
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Senior Member
Join Date: Nov 2007
Posts: 210
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hey verna.. congrats... the tras-dm1 study is going very well.. right now, 5 ladies from this board are using tras-dm1... barb, mpb, chrisy,lily.. and someone else who escapes me at the moment. i think eric's wife caryn is checking out this study also..
lilly did well on it for the last 4 months ,but now had a hiccup..
ky home starts next week on the 13th....
please keep us posted.. since you are in florida .. i presume you are doing the every 3 week dosing schedule..
run to live
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03-07-2008, 05:44 PM
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#3
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Senior Member
Join Date: Sep 2007
Location: Tampa, FL
Posts: 43
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Run to Live,
Is that what it's known as...tras-dm1? I've heard some call it Super Herceptin. I'm just excited to be part of it. I will get my first treatment Monday, and I will keep you all posted on the results. This is very exciting to me. I feel this might be the miracle treatment. Yes, it will be every 3 weeks.
Hugs-Verna
__________________
stage IV, diagnosed Nov.11,2005
mets to spine,hips,pelvic,femur
4 a/c
mastectomy Feb.14,2006
4 taxol
mets to liver
5 weeks radiation
Herceptin/Zometa
reconstruction Feb.14,2007 (DEIP)
Tykerb/Xeloda
TDM1 study
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03-07-2008, 06:47 PM
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#4
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Senior Member
Join Date: Sep 2005
Posts: 232
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Vera,
I am so happy for you.
Hugs, prayers and positive thoughts being sent to you.
Karen
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03-07-2008, 10:00 PM
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#5
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Senior Member
Join Date: Sep 2006
Location: Houston, Texas
Posts: 624
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Good luck with your new treatment. I will keep you in my thoughts and prayers.
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03-17-2008, 10:21 AM
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#6
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Senior Member
Join Date: Nov 2007
Posts: 210
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verna.. when are u scheduled to begin treatment.
run
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03-17-2008, 10:43 AM
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#7
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Senior Member
Join Date: Jun 2007
Posts: 2,210
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Verna, you probably have had your first treatment now. Hope to hear how it went for you.
Best wishes. Keep the faith.
__________________
Bonnie
Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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04-07-2008, 08:54 AM
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#8
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Senior Member
Join Date: Nov 2007
Posts: 210
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verna.. how was your first treatment.
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04-07-2008, 01:43 PM
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#9
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Senior Member
Join Date: Sep 2005
Location: Newton, MA
Posts: 951
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Trial
Hi Verna,
Go to the clinical trial message section to learn more about how members are doing on this trial.
Best wishes,
Barbara H.
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04-07-2008, 02:39 PM
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#10
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Senior Member
Join Date: May 2006
Location: northshore suburb of chicago
Posts: 1,093
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Hope you have great results with this new treatment. Let us know how it is going.
__________________
~Rina~
Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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04-07-2008, 04:14 PM
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#11
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Senior Member
Join Date: Sep 2007
Location: Tampa, FL
Posts: 43
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Hi all,
Just wanted to check in with you all and let you know I've had my 2nd treatment a week ago. The first was just like the first time I did Herceptin...flu like symtoms, the second one, piece of cake.
Sorry I have not responded sooner, been so busy.
More updates after I get my PET scan.
Hugs-Verna
__________________
stage IV, diagnosed Nov.11,2005
mets to spine,hips,pelvic,femur
4 a/c
mastectomy Feb.14,2006
4 taxol
mets to liver
5 weeks radiation
Herceptin/Zometa
reconstruction Feb.14,2007 (DEIP)
Tykerb/Xeloda
TDM1 study
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04-23-2008, 11:25 AM
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#12
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Senior Member
Join Date: Nov 2007
Posts: 210
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verna.. how has the new treatment been going.. did u have the pet scan yet..
run to live
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04-23-2008, 11:34 AM
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#13
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Senior Member
Join Date: Mar 2007
Location: CHARLOTTE NC USA
Home town (ECUADOR) South America
Posts: 542
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verna, in my treatment center all the lady's that are enroll are doing fine with DM1
__________________
Lily Diag April/06 5 months after give birth my son Max stage IV mets on liver (5 tumors) 38 year old, her2+++ and ER+PR+ from32 nodes 4 positives mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery 5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression 03-05-08 start tykerb & xeloda
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04-23-2008, 12:18 PM
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#14
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Senior Member
Join Date: Nov 2007
Posts: 210
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lily .. how many tras-dm1 are being treated at your site in NC...
run to live
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04-23-2008, 02:03 PM
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#15
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Senior Member
Join Date: Mar 2007
Location: CHARLOTTE NC USA
Home town (ECUADOR) South America
Posts: 542
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maybe 4 they are doing well
__________________
Lily Diag April/06 5 months after give birth my son Max stage IV mets on liver (5 tumors) 38 year old, her2+++ and ER+PR+ from32 nodes 4 positives mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery 5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression 03-05-08 start tykerb & xeloda
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04-23-2008, 05:36 PM
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#16
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Senior Member
Join Date: Sep 2007
Location: Tampa, FL
Posts: 43
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Ladies, my 3rd treatment was Monday. I have a PET scan tomorrow. Hope to have results on Friday to share. All has been good so far. Just a few things; dry mouth, hands & feet feel like the old Taxol treatment (numbness & tingling)and, hard to focus on my vision.
Hugs-Verna
__________________
stage IV, diagnosed Nov.11,2005
mets to spine,hips,pelvic,femur
4 a/c
mastectomy Feb.14,2006
4 taxol
mets to liver
5 weeks radiation
Herceptin/Zometa
reconstruction Feb.14,2007 (DEIP)
Tykerb/Xeloda
TDM1 study
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06-06-2008, 10:29 AM
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#17
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Senior Member
Join Date: Nov 2007
Posts: 210
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verna, how has the trial been going...
run
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06-06-2008, 01:30 PM
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#18
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Senior Member
Join Date: Sep 2007
Location: Tampa, FL
Posts: 43
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Update on T-DM1 study:
Had 5th treatment Monday. All going good. PET/CT scan good, cancer out of my liver and back nodes. I have another one on the 18th. Anyone ever hear anything about these scans being harmful?
__________________
stage IV, diagnosed Nov.11,2005
mets to spine,hips,pelvic,femur
4 a/c
mastectomy Feb.14,2006
4 taxol
mets to liver
5 weeks radiation
Herceptin/Zometa
reconstruction Feb.14,2007 (DEIP)
Tykerb/Xeloda
TDM1 study
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06-06-2008, 01:52 PM
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#19
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Senior Member
Join Date: Dec 2007
Location: Avilla, Indiana
Posts: 261
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Verna,
Glad to hear your treatments with the tras-dm1 are going well.
Dana
__________________
-Dana-
]
Diagnosed - Nov. 2, 2007 at 45
Lumpectomy - Nov. 13, 2007
Tumor 1.2 cm
Stage 1 Grade 3
ER/PR - Her2 +++ (3.8)
Taxotere/Carboplatin/Herceptin- 6 rounds
Neulasta
Radiation 33 treatments - will be done 6/6/08
Herceptin through 12/08
12/07 MUGA 61%, 4/08 MUGA 60%, 7/08 MUGA 64%
three wonderful daughters, a terrific husband,
Life is Good
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06-06-2008, 05:12 PM
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#20
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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HI Verna,
Glad to hear you're doing so well! I'm in the same study and just had my 6th treatment Wednesday...so I'm due for another set of scans.
I too am not happy about the number of scans, it just doesn't seem good to have all that radioactive stuff over and over. I'm now on a 28 day dosing schedule instead of the 21 days, so at least I will get to have an 8 week interval instead of 6 weeks!
On one hand, they want to be sure they can tell what's going on with the efficacy of the treatment...but geez!
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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