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Just a comment or miro-met spread due to surgery; there are two schools of thought, one is the dislodging theory and for HER2, the growth factor theory (ie HER2 is a growth factor stimulated by surgical healing). There has been some recent and very successful work done with continuous 5-FU infusion as surgical prep; Continuous 5-FU during surgery and for days after, knowing that things may dislodge. There is very little evidence that fine needle biopsies dislodge.
Al
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Primary care-giver to and advocate for Linda, who passed away April 27, 2006.
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Hybrid Mode
