Pomegranate fruit extract impairs invasion and motility in human breast cancer

[Rich66]

*might not be compatible with chemo etc.






Pomegranate fruit extract impairs invasion and motility in human breast cancer
Integrative Cancer Therapies , 10/12/09

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• Free Abstract

Khan GN et al. – Inhibition of motility and invasion by PFEs, coincident with suppressed RhoC and RhoA protein expression, suggests a role for these defined extracts in lowering the metastatic potential of aggressive breast cancer species.
Methods

• Investigated effect of novel, defined PFE consisting of both fermented juice and seed oil on NF-kB pathway, which is constitutively active in aggressive breast cancer cell lines
• Effects of PFE on NF-kB—regulated cellular processes such as cell survival, proliferation, and invasion also examined

Results

• Analytical characterization of bioactive components of PFE revealed active constituents, mainly ellagitannins and phenolic acids in aqueous PFE and conjugated octadecatrienoic acids in lipid PFE derived from seed
• Aqueous PFE dose-dependently inhibited NF-kB—dependent reporter gene expression associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression