"Molecular factors implicated in CNS metastases and LM include E-cadherin–catenin complexes, plasmin, urokinase-type plasminogen activator, metalloproteinases, tissue inhibitors of metalloproteinases (associated with brain invasion), and activated integrin αvβ3. Metalloproteinases can degrade endothelial tight junction proteins at the BBB. Along with vascular endothelial growth factor (VEGF) and stromal-derived factor metalloproteinases may allow for transendothelial migration of tumor cells.
New Strategies in the Management of Leptomeningeal Metastases
http://archneur.jamanetwork.com/mobi...ticleid=799479
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