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Old 11-12-2005, 12:07 PM   #1
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significantly reduce the growth rate and angiogenesis of a human breast cancer

More on fats -

There is significant evidence that the omega three reduces breast cancer, omega six increases it, and to maintain a body balance of onene, and not worse than one to four omega three to six highly significant for breast cancer and general health.

I have seen more more consistent evidence to support this than any other aspect of diet.

Please see the other tow fats links.

http://www.cancerci.com/content/5/1/12



ABSTRACT


"Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis


"There are reports that an n-3 fatty acid enriched diet can suppress mitosis and growth of breast and colon tumors [1,6,9]. Thus, it was not surprising to find that the n-3 diet also suppressed the metaphase index in viable areas of the breast cancer tumors in this study.
Together the data reveal that consumption of the n-3 containing diet resulted in a decrease in tumor growth rate, cell proliferation (Fig. 7) and blood vessel volume density (Fig. 5A). Hardman [24] has reviewed some of the possible molecular mechanisms involved in suppression of tumor growth by addition of n-3 fatty acids to the diet. The mechanisms involved in suppression of tumor growth by an omega-3 fatty acid enriched diet include: 1) decreased expression of cyclooxygenase-2, " reducing angiogenesis and decreasing cancer cell proliferation, 2) suppression of nuclear factor κB activation and bcl-2 expression, allowing apoptosis of cancer cells, 3) suppression of the oncogenes AP-1 and ras, 4) induced differentiation of the cancer cells, 5) reduction in aromatase activity that decreases estrogen levels, 6) inhibition of later steps in the tumor angiogenesis process.


Conclusion

In conclusion, an omega-3 fatty acid enriched diet was found to significantly reduce the growth rate and angiogenesis of a human breast cancer xenograft without evidence of harmful side effects."

RB
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