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Old 10-10-2007, 07:25 AM   #1
Becky
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Does Stress Cause Disease?

http://www.medpagetoday.com/Psychiat...tress/tb1/6926
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Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 10-10-2007, 09:48 AM   #2
Sandy in Silicon Valley
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Thumbs down doubts about the applicability of this study

Hi, Becky -

Thanks for posting this link - though I believe it's been posted here previously. However, I'd like to reiterate my numerous objections to where this research is right now, and the premature conclusions that are being (IMO, wrongfully) drawn.

Dr. Sheldon Cohen, author of this JAMA study, is a psychologist, not an M.D. It stands to reason that he would guess at psychological etiology of diseases, rather than the plethora of other factors that MIGHT be more pertinent, like environmental toxins, worsened living conditions, more treatment-resistant organisms, compromised immune systems due to genetic factors, etc.

What I noticed, in reading the link you provided, is how many, many times Cohen qualifies his guesses with words like "might", "may", "could" - and the numerous times he admits that the verdict is still not in about which came first, the disease origin or the stress, and even whether the bio-chemical responses to stress that sometimes occur in humans are ultimately CAUSING diseases or exacerbation of disease symptoms.

I'm still very skeptical that this kind of guessing merits any credence at all - especially as pertains to breast cancer, when viral origin isn't even determined. Also, the whole idea that stress is bad for people has been refuted - a few times in studies of the effect of work stress on nurses - where it was found that those who reported moderate-to-severe stress were LEAST likely to develop breast cancer, even years later.


Secondly, why not do away with stress altogether, by better living through chemistry, if it's such a disease- causing factor in our lives? How 'bout legalizing marijuana, handing out Quaalude, Valium, Xanax, Ativan, Vicodin, even Versed to anyone who reports being under stress? Other than that many stressed-out, productive people would likely lose productivity, and others would be unmotivated to work on resolving their stress-inducing problems, maybe we could rechannel this "blame the victim" perspective.

For those of us on this list, who've already been dx'd with breast cancer, IMO it's really unhelpful to promulgate the notion that if we somehow got rid of the stress in our lives (often caused or increased by knowing we have the disease, or by undergoing noxious treatments & suffering mutilating surgeries and QOL- impeding side effects), we'd be enhancing our chances for recovery.

Thanks for providing the opportunity for another rebuttal.

(((hugs)))
Sandy in Silicon Valley
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1992 - age 44/ ER-/PR+ Stage II dx - mastectomy, CAF x 6 cycles; Tamoxifen
1997 - BRCA1 mutation dx'd
1998 - ovaries removed
1999 - off Tamoxifen, on Arimidex
2003 - dx'd Stage IV - lymph nodes & lungs. ER-/PR-/HER2neu+++.
Tx: Herceptin & Taxotere (6 cycles).
2005 - 2.9cm x 3.6cm brain tumor. Craniotomy, CyberKnife. 9 mo. staph aureus infection at incision site - 2nd craniotomy. Two small brain mets CyberKnife'd.
2006 - revisit Xeloda - dosage lowered to 2500mg/day, 5 cycles.
2007 - "spot" dx'd on qtrly brain MRI - same location as CyberKnife 7/05. > by 2-4mm per quarter - - radiation injury or re-growing cancer? Tykerb added to Herceptin - July, still "watching & waiting". Otherwise, fully functional...


"The majority of people are not only afraid of holding a wrong opinion, they are afraid of holding an opinion alone." Kierkegaard
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