Any info on HKI-272?

TheresaM · 05-01-2007, 03:00 PM

Hi all, just to update you: I did exactly one month on Wyeth's tyrosine kinase inhibitor HKI-272 in a phase II trial at Seattle. It did not work on me, my lung mets progressed massively in that time and I'm now on oxygen, contemplating Hospice vs one last-ditch effort a chemo, which never helped me before.

Just wanted others contemplating this drug to know of my experience,

Theresa

MaggieD · 05-08-2007, 06:59 PM

Hi,

I thought I would update you all on my sister's progress. She did go on the HKI trial and did OK on it for ~4 months. There was some slight progression in her latest scans so it is time to look for something new now.

Of course, we would have liked this treatement to work much longer, but the side effects of this drug were minimal. My sense is that her prior treatment (combination of tykerb/herceptin) was more effective for her even though she was on that trial for about the same amount of time.

Jo-Ann, I would seek out another opinion if they are considering starting you out on this drug and you are newly diagnosed. This drug does hold some promise, but it is in the early trial stages. There are many treatments out there to consider with a history of success behind them.

MaggieD

vickie h · 06-01-2007, 05:25 PM

HKI-272 is almost exactly the same as Tykerb, another Tyrosine Kinase Inhibitor. There is some minute difference as per my Onc. So chances are if you fail on HKI, you won't do any better with Tykerb or BIBW-1229 or many of the other Tyrosine Kinase Inhibs now in studies. My friend is on HKI and doing really well, except for Diarhea and rashes, her skin mets and lymph are clearing up. She has been flying to Denver for treatments for 2 months now. Good luck and I hope this works for you. Love, Vickie

Heide · 07-24-2007, 02:20 PM

I went on the HKI-272 trial in January 2007 for positive nodes in supraclavicular area. The nodes were noticeably smaller by touch within 1 week of starting the drug. I went for 5 months before nodes started to swell again and last petscan showed positive nodes in supraclav again and very small positive node in chest wall near my windpipe. Diarrhea and splitting of fingertips and toes are the only side effects I've had with the HKI but it's been quite manageable. My Onc has also told me that HKI is very similiar to Tykerb(lapatinib) but that Tykerb in combo with chemo drug capecitabine might be the next step for me.