The traditional diet of Greece and cancer.

[kat in the delta]

Help me Robbie,
So is olive oil good or NOT good for you..Can you tell me some common foods and oils that ARE GOOD for you...Then, tell me those that are NOT as good for you
I would appreciate your help.........this has been alot for me to absorb as I just started from the top of this thread...thanks,
KAT

[R.B.]

Well done for making the effort to try and understand this huge subject.

It is as usual complicated, but I will try and deal with the basics.

Olive oil is a complex mix of a lot of fats and chemicals.

This link gives an idea as to the mix of fats it contains. http://www.nutritiondata.com/facts-C00001-01c208D.html
18:1 is likely to be mainly oleic, 18:2 linoleic (omega six) 18:3 linolenic (omega three). So in olive oil you are getting a mix of fats, and mainly mono saturates (1 double bond eg 18:1 - 18 the number of carbons - 1 the number of double bonds.)

Mono saturates are better to cook with as they oxidise less, but add what you need for taste etc at end,

But if you use a lot it is important to rember 10% - 15% of a virgin oil and up to 50% of a processed oil is omega six.

There are also other chemicals in olive oil that are reported to have a benificial effect.

http://www.her2support.org/vbulletin...ight=olive+oil


So in general terms,
- moderation - less is probably more in general terms
- be very aware to add in the omega six it contains in working out approx your three six intake.
- use only quality virgin oils
- remember the body can make omega nines but it is complex and your body may appreciate a helping hand with provision of a little

Every body is different and will metabolise fats differently. If it is a choice becuase you do not tolerate fat or some other reason I would put fish oil first, and include a little olive oil now and then.


This thread may help too

http://www.her2support.org/vbulletin...ight=olive+oil


And this one.

http://www.her2support.org/vbulletin...ight=olive+oil



In general diet terms on diet - there are lots of books many of which cover more or less the same ground. Here are some thoughts but best check out some book at the library if you get time.

- as wide a variety as possible (a green food supplement is a way of getting some things you would not usually include in your diet Green Frog as a make is quite good)
- Green things and lots of them, frozen if fresh is not available spinach, broccoli etc. highly coloured fruit and veg, some dried seaweed.
- Some nuts mixed as much as will fit on your palm.
- Some pulses if your digestion will tolerate them
- Whole grain but in strict moderation and better pre germinated as reportedly easier to digest.
- a little occasional grass fed meat, farm raised chicken, offal etc if you are not vegitarian - corn fed animals have higher level of omega six
- fish including oily - small quick growing are less likely to be polluted sardines, mackerel - but again variety - all fish is good but wild is better.
- a variety of herbs and spices, ginger, curcumin, .....
- cut out vegetable oils except a little flaxseed (do not cook), maybe canola, perillia etc but you must watch the six content and strictly in moderation
- some fish oil to bring your intake of DHA up to about 2 grams a day.

Avoid "processed food" as in manifiactures prepreapred etc as far as is practicable - just because they usually contain vegetable oils etc. or at least read the label first, and regretabl they end up sadly going back on the shelf most times.

Sugar, sugar subsitutes, high salt levels, are very definate avoids.

So between sugars and vegetable oils most processed food is out.

Rhonda's "Cancer Diet" posted on this site is thought provoking.

Some suggest dairy and some say no. For those that tolerate it maybe a tiny bit of butter, maybe yogourt, maybe goats cheese, but small quantities.

You will find your taste changes and previous treats like crisps etc strangely end up tasting less desireable.

Getting ones digestion sorted out is key, which may mean no sugar, avoiding grains which can be difficult to digest for some, (Breaking the Vicious Cycle Elaine Gotterschall - is an interesting book on digestion - but may not be ideal receipies in respect of balancing omega threes and sixes, (high omega six in almonds) and I would have concern about too much honey....) for a bit etc.

Etc.

Do talk to your doctor about significant dietary change.

I hope the above helps. I am afraid beyond the basics you will have to find what suits you.

RB

[R.B.]

More straws in the wind.

Melanoma this time.

Another wild thought on the edge - As a short term measure? - Boost threes, NSAIDS to block six and force body to use up six reserves and at the same time cut down omega six intake ???

All significant changes to diet should be discussed with your medical advisor.

RB


Department of Biology, The Chinese University of Hong Kong, Shatin, China. chimingchiu@graduate.hku.hk

Recent studies have suggested the inhibition of cyclooxygenase-2 (COX-2) as strategy to prevent colorectal cancer. In this study, the cytostatic and cytotoxic effects of different non-steroidal anti-inflammatory drugs (NSAIDs), all of them are reported COX inhibitors, were investigated in human skin melanoma A-375 cells. Using BrdU-cell proliferation assay, we showed that 50 and 100 microM of celecoxib (CEL) reduced proliferation of the melanoma cells at 72-h incubations by 34.0% and 82.7%, respectively. As determined by Toxilight-cytotoxicity assay, the drug was only toxic to the cancer cells at 100 microM. Indomethacin (IND) also inhibited the cell proliferation by about 40% at 240 and 480 pM and was only slightly toxic to the melanoma. Neither aspirin (ASP) nor piroxicam (PIR) exhibited cytostatic or cytotoxic effect on the cancer cells. Combinatory effects of the above NSAIDs with dietary docosahexaenoic acid (DHA) on inhibiting growth of the melanoma cells were further elucidated. Each of the NSAIDs, at doses 10-480 pM, was incubated simultaneously with the melanoma cells and 160 pM of DHA for 72 h. Results from MTT assay showed that both CEL and IND, starting from 20 microM. exhibited additive effects on the DHA-induced growth inhibition. ASP also enhanced the DHA-induced growth inhibition by 42.8% at 480 microM. To our surprise, although PRX did not suppress the melanoma growth, the drug at 40-240 microM enhanced the DHA-induced growth inhibition by 15.9-66.4%, respectively. Results from these studies suggest that the anticancer effects of NSAIDs may not be explained solely by their COX-inhibitory activities. Further studies are therefore required to understand their modes of action, before they could be used alone or in combinations with other agents for cancer chemoprevention.

PMID: 16507396 [PubMed - indexed for MEDLINE]

[R.B.]

The same principle DHA plus NSAID shows possibility in Prostate Cancer.

RB


http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15703837

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA. nnarayan@env.med.nyu.edu

Epidemiological studies have provided evidence that high intake of saturated fat and/or animal fat increases the risk of prostate cancer, but on the other hand, diets rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs), present in fish oils were found to reduce the risk. There are indications of an increased expression of immunoreactive PPARgamma in prostatic intraepithelial neoplasia (PIN) and prostate cancer, suggesting that PPARgamma ligands may exert their own potent anti-proliferative effect against prostate cancer. The experimental evidence for the role of cyclooxygenase-2 (COX-2) in prostate carcinogenesis is well established through several investigations. It clearly suggests the need for development of strategies to inhibit COX-2 mediated prostate carcinogenesis. However, administration of high doses of COX-2 inhibitors, such as celecoxib, over longer periods may not be devoid of side effects. We assessed the efficacy of DHA and celecoxib individually and in combination at low doses in three prostate cancer cell lines (LNCaP, DU145 and PC-3) measuring cell growth inhibition and apoptosis, and on the levels of expression of COX-2, nuclear factor-kappaB (NF-kappaBp65), and nuclear receptors, such as PPARgamma and retinoid X receptors (RXR), all of which presumably participate in prostate carcinogenesis. A 48-h incubation of prostate cancer cells with 5 microM each of DHA or celecoxib induced cell growth inhibition and apoptosis, and altered the expression of the above molecular parameters. Interestingly, the modulation of these cellular and molecular parameters was more pronounced in cells treated with low doses of DHA and celecoxib (2.5 microM each) in combination than in cells treated with the higher doses of individual agents. In conclusion, the present study demonstrates for the first time that a combination of lower doses of the n-3 PUFA, and DHA with the selective COX-2 inhibitor celecoxib effectively modulates the above cellular and molecular parameters that are relevant to prostate cancer. This raises the intriguing prospect that the use of low doses of a COX-2 inhibitor in combination with an n-3 PUFA could be a highly promising strategy for prostate cancer chemoprevention while minimizing undesired side effects.

PMID: 15703837 [PubMed - indexed for MEDLINE]

[R.B.]

And Colon Cancer...

A subject for for your oncs?

RB


Chemoprevention and Nutritional Carcinogenesis Program, Institute for Cancer Prevention, American Health Foundation-Cancer Center, Valhalla, NY, USA.

To develop efficient synergistic or additive combinations of chemopreventive and nutritional agents to reduce the risk of colon cancer, experiments were designed to test the application of a selective cyclooxygenase-2 (COX-2) inhibitor together with dietary omega-3 polyunsaturated fatty acids (PUFAs), such as decosahexaenoic acid (DHA). Thus, individual application of celecoxib, a COX-2 inhibitor, DHA, a omega-3 PUFA, and combinations of both were tested for their effectiveness using cell proliferation, apoptosis, and COX-2 expression as markers in the human colon cancer HCA-7 cell line. HCA-7 cells exposed to various subtoxic doses of celecoxib, DHA, or combinations of both were analyzed for inhibition of cell proliferation by trypan blue exclusion and proliferating cell nuclear antigen methods, induction of apoptosis by 4',6-diamidino-2-phenylindole method, and COX-2 by reverse transcription-PCR and Western blot analysis. In addition, we examined the inhibitory potential of celecoxib and DHA on (14)C-arachidonic acid metabolism mediated by COX-2 in the HCA-7 cell line. We found that treatment with celecoxib (50-150 micro M) or DHA (150-225 micro M) individually induces apoptosis and inhibits cell proliferation only at high concentrations in HCA-7 cell lines. A synergistic effect was observed on induction of apoptosis and inhibition of proliferation when cells were exposed to low doses of celecoxib (50-100 micro M) together with DHA (75 micro M). At high concentrations, celecoxib and DHA blocked the increase in COX-2 protein and mRNA expression in HCA-7 cells. Importantly, the inhibition of COX-2 expression was more pronounced in cells treated with low-dose combinations than with individual agents at high concentrations. In addition, celecoxib and DHA at low-dose levels inhibited (14)C-arachidonic acid metabolism (50-85%, P < 0.0001) leading to very low levels of type 2 series prostaglandin formation. These findings provide the basis for the development of combinations of low-dose regimens of a COX-2 inhibitor and omega-3 PUFAs such as DHA for the prevention and treatment of colon cancer. We are currently testing this concept in preclinical models.

PMID: 14985462 [PubMed - indexed for MEDLINE]

[R.B.]

Combined with the above I think this might even merit a smiley.


Would omega three plus low dose COX blocker yield even better result.


Maybe deliver as intravenous lipid feed plus cox blocker ?


As ever changes to diet should be discussed with your medical advisor.

RB


http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. ydenkins@vetmed.lsu.edu

Cyclooxygenase-2 (COX-2) is important in the progression of epithelial tumors. Evidence indicates that omega-6 PUFAs such as arachidonic acid (AA) promote the growth of tumor cells; however, omega-3 fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] inhibit tumor cell proliferation. We investigated the effects of omega-3 PUFA on the expression and function of COX-2 in 70W, a human melanoma cell line that metastasizes to the brain in nude mice. We show that 1) tumor necrosis factor-alpha upregulates the expression of both COX-2 mRNA and prostaglandin E2 (PGE2) production, and 2) omega-3 and omega-6 PUFA regulate COX-2 mRNA expression and PGE2 production. AA increased COX-2 mRNA expression and prostaglandin production in omega-6-stimulated 70W cells. Conversely, COX-2 mRNA expression decreased in cells incubated with EPA or DHA. AA increased Matrigel invasion 2.4-fold, whereas EPA or DHA did not. Additionally, PGE2 increased in vitro invasion 2.5-fold, whereas exposure to PGE3 significantly decreased invasion. Our results demonstrate that incubation of 70W cells with either AA or PGE2 increased invasiveness, whereas incubation with EPA or DHA downregulated both COX-2 mRNA and protein expression, with a subsequent decrease in Matrigel invasion. Taken together, these results indicate that omega-3 PUFA regulate COX-2-mediated invasion in brain-metastatic melanoma.

PMID: 15772428 [PubMed - indexed for MEDLINE]

[R.B.]

Busy little things these n-3s ?

RB




http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15358633

Institute of General Pathology, Catholic University, L.go F. Vito, 1, 00168 Rome, Italy. g.calviello@rm.unicatt.it

n-3 Polyunsaturated fatty acids (PUFAs) inhibit the development of microvessels in mammary tumors growing in mice. Human colorectal tumors produce vascular endothelial growth factor (VEGF) whose expression is up-regulated in tumor cells by both cyclooxygenase-2 (COX-2) and PGE(2) and directly correlated to neoangiogenesis and clinical outcome. The goal of this study was to examine the capability of n-3 PUFAs to regulate VEGF expression in HT-29 human colorectal cells in vitro and in vivo. Constitutive VEGF expression was augmented in cultured HT-29 cells by serum starvation and the effects of eicosapentaenoic (EPA) or docosahexaenoic acid (DHA) on VEGF, COX-2, phosphorylated extracellular signal-regulated kinase (ERK)-1 and -2 and hypoxia-inducible-factor 1-alpha (HIF-1alpha) expression and PGE(2) levels were assessed. Tumor growth, VEGF, COX and PGE(2) analysis were carried out in tumors derived from HT-29 cells transplanted in nude mice fed with either EPA or DHA. Both EPA and DHA reduced VEGF and COX-2 expression and PGE(2) levels in HT-29 cells cultured in vitro. Moreover, they inhibited ERK-1 and -2 phosphorylation and HIF-1alpha protein over-expression, critical steps in the PGE(2)-induced signaling pathway leading to the augmented expression of VEGF in colon cancer cells. EPA always showed higher efficacy than DHA in vitro. Both fatty acids decreased the growth of the tumors obtained by inoculating HT-29 cells in nude mice, microvessel formation and the levels of VEGF, COX-2 and PGE(2) in tumors. The data provide evidence that these n-3 PUFAs are able to inhibit VEGF expression in colon cancer cells and suggest that one possible mechanism involved may be the negative regulation of the COX-2/PGE(2) pathway. Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed.

PMID: 15358633 [PubMed - indexed for MEDLINE]

[kat in the delta]

All I know is that Cancer seems to GROW in an ACIDIC BODY. WE need to find out ALL the foods that NEUTRALIZE the acid to make our bodies MORE ALKALINE. You would not believe Which foods they are--example apples and oranges...Who will make the list ? gotta get off --kat in the delta

[kat in the delta]

1. Eat food to make our bodies more alkaline.

2. get rid of the magnetic chaos around us

3. Detox our bodies--colon, liver,,,,,etc

4. Learn to deal or get rid of stress

Really all of these can make our bodies acidic which we want to REVERSE-kat in the delta

rsvp what do YOU ALL think ??????????

[R.B.]

This is an abstract from an article I saved.

I will try and find the link to it and post it.

Thank you for bringing it up as a subject.

This seems to sum it up plus carbonated drinks, and I wonder about vitamin C unbuffered when used as a preservative etc. I also cannot recall the situation re orange juice etc, which in addition in high quantities is a source of fruit sugars which in excess - all healthy things in moderation. I have started significantly diluting all purchased fruit juices.

"fish, meat, poultry, eggs, shellfish, cheese, milk, and cereal grains are net acid producing, whereas fresh fruit, vegetables, tubers, roots, and nuts are net base producing. Legumes yield near-zero mean acid values. Salt is net acid producing because of the chloride ion."



“fish, meat, poultry, eggs, shellfish, cheese, milk, and cereal grains are net acid producing, whereas fresh fruit, vegetables, tubers, roots, and nuts are net base producing. Legumes yield near-zero mean acid values. Salt is net acid producing because of the chloride ion. …As a result, healthy adults consuming the standard US diet sustain a chronic, low-grade pathogenic metabolic acidosis that worsens with age as kidney function declines. Virtually all preagricultural diets were net base yielding because of the absence of cereals and energy-dense, nutrient-poor foods—foods that were introduced during the Neolithic and Industrial Eras and that displaced base-yielding fruit and vegetables ”


I hope this helps a little.

RB

[Mary Anne in TX]

I did a google search of alkaline & acid foods and found some charts that were really good, but on some items them differed! It really did help though! I'll keep reading them to find the ones that most often agree!
Watching what I eat has helped me so much these past 10 months!

[kat in the delta]

Thanks for looking us the info on foods--WE all need foods that Neutralize the acid in our bodies because cancer and most diseases love to live in an acidic body. I found that you can replace reg.salt with Sea Salt which is more alkaline(NONacid).
What about MILK----
Cancer craves SUGAR--so refined sugar should be a NO-NO for all of us. I guess someone or all of Us can make a list of Acid forming foods and a list of Foods that neutalize acid
--Any volunteers ??? I cannot stay on net long now......
Which are good site ?? from the Mayo Clinic, or MDAnderson, or Memorial Sloan Kettering Cancer Center or some dietician page or nutrition page.....Let me know what you all find out and we can all help each other ....................kat in the delta

[Heart Sutra]

Hi,

Thought I would look up The Lyon Study, since it was quoted as reducing coronary disease, and cancer mortality.

Alas, I could find no reference to cancer within the study.

Maybe I found the wrong one? Seems like all roads point back to this one study, and it was designed to rate coronary disease recurrance.
The study had flaws. Mainly lack of control of its "control" group, and exceedingly small sample. 300+ each of experimental and control individuals. The diet of either group was assessed once. Less than a third of the control, and less than half of the experimental group, provided dietary data at the final meeting.

The conclusion is that the role of diet is uncertain regarding this particular study of recurrant coronary events(!) Encouraging results were had, but the study was flawed enough to make it no more than interesting...far from conclusive. Again, nothing at all about cancer.

So, maybe I found the wrong study. There was another one based in France by the same name, but it was also a study of coronary illness, and no mention is made of cancer.

There does seem to be quite an interest in diet and cancer links.
There must be more carefully conducted studies somewhere of this topic.

Whenever a study is quoted, it's good to review the source of the study. There are a lot of claims out there...

[R.B.]

Thank you for your comment. All debate is good. I have not looked at the Lyon study in detail

http://www.americanheart.org/present...dentifier=4655

but there is a huge amount of evidence that diet has potential impact on risk factors for disease. At the most basic levels diet influences gene expression which is a fundamental mechanism in regulating body function.

If you get time you mike like to look at some of the links provided which in turn open out into a plethora of further trials. If you search on NCBI and dietary factors of interesrt and cancer you will find a huge number of trials.

Here is a view from the Mayo Clinic



http://www.mayoclinic.com/health/fis...atient-fishoil

"There is evidence from multiple large-scale population (epidemiologic) studies and randomized controlled trials that intake of recommended amounts of DHA and EPA in the form of dietary fish or fish oil supplements lowers triglycerides, reduces the risk of death, heart attack, dangerous abnormal heart rhythms, and strokes in people with known cardiovascular disease, slows the buildup of atherosclerotic plaques ("hardening of the arteries"), and lowers blood pressure slightly. However, high doses may have harmful effects, such as an increased risk of bleeding. Although similar benefits are proposed for alpha-linolenic acid, scientific evidence is less compelling, and beneficial effects may be less pronounced."

RB

[R.B.]

In essence much still to know but for HER 2

Omega three - good
Omega nine - good
low Omega six - good

Clearly as usual it is not that simple but the summary below adds to the weight of evidence that strict moderation of fat intake, balancing the omega threes and sixes and quality of intake are well worth serious consideration.

As usual if undertaking significant dietary change please talk to your advisers.





http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17134970

ABSTRACT

CONCLUSIONS: i) These findings reveal that the omega-3 PUFA ALA suppresses overexpression of HER2 oncogene at the transcriptional level, which, in turn, interacts synergistically with anti-HER2 trastuzumab- based immunotherapy. ii) Our results molecularly support a recent randomized double-blind placebo-controlled clinical trial suggesting that ALA may be a potential dietary alternative or adjunct to currently used drugs in the management of HER2-positive breast carcinomas. iii) Considering our previous findings demonstrating the <<HER2 upregulatory actions>> of the omega-6 PUFA linolenic acid (LA; 18:2n-6) and the <<HER2 down-regulatory actions >> of the omega-3 PUFA docosahexaenoic acid (DHA; 22:6n-3) and of the omega-9 monounsaturated fatty acid oleic acid (OA; 18:1n-9), it is reasonable to suggest that a low omega-6/omega-3 PUFA ratio and elevated MUFA levels, the two prominent <<fat features>> of the <<Mediterranean diet>>, should be extremely efficient at blocking HER2 expression in breast cancer cells.

[R.B.]

Why did I bring up the coronary issue

Because a previous post suggested omega three had no impact on coronary health. A positive impact on coronary health is one of the area that does seem to be accepted by a growing number of the medical profession.

Re impact of omega three - it is complex. The eicosanoid pathway is fundamental to the bodies mechanisms, and omega three and six play a very big part in it. Omega three and six have been reported as impacting on a huge number of health issues.

Re repeating - I take oil and not capsules. I used ot have a problem with repeating with cod liver oils oils but do not have a problem with the seven seas extra strength or Vita Cost Carlsons lemon flavoured. I do not know if these oils are more refined. Omega three has been shown to reduce IBS which is a factor in poor digestion.

Food does alter gene expression, this includes BRAC and HER 2. the difference between a high omega six and balanced 3/6 has been shown to produce changes of gene expression by a factor of ten for some gene in rodents. There are a number of small trials suggesting that omega three intake does play a part in cancer risk reduction, but there is a lack of wider trials

This is a good starting point on the huge subject of fats.

http://www.benbest.com/health/essfat.html

Other supplements is a whole huge other issue on which I make no comment.

To balance the omega threes and sixes you have to look at your intake and fat content. This is a good link. It is a bore at first but it does not take long to get an idea as to what contains high levels of omega six.

http://www.nutritiondata.com/topics/fatty-acids

Otherwise it is more of the usual - avoid processed foods, sugar, trans fats,....lots of variety - lots of green things - small quantity of nuts - as generally discussed in many healthy eating books.

It is not easy, there is much mixed information and my suggestion is to read round the topic and come to your own conclusions.


RB

[heblaj01]

Julierene,
You appear to have difficulties in digesting fish oil pills. Setting aside an allergy to seafood, it is possible you need taking digestive enzymes at the same time as the oil pills, in particular the lipase enzyme.
Lipase & other digestive enzymes are also indicated for some people with poor bile &/or pancreatic secretion or whose gallbladder has been resected or is not functioning because it is filled with stones. I am in this latter category & I take enzyme supplements with oil pills.
It is also preferable to take oil pills at the end of meals.

NOTE:
A simple check to find out if someone has problems in digesting fats is the color of stools: yellowish is indicative of poor digestion.

[R.B.]

More indications fats are in the thick of things....

DEFINATELY WORTH STRUGGLING TO UNDERSTAND


http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17168666

ABSTRACT

"A recent discovery that dietary fatty acids can interact with the human genome by regulating the amount and/or activity of transcription factors has opened a whole new line of research aimed to molecularly corroborate the ant-cancer benefits of the olive oil-based Mediterranean diet and the underlying mechanisms. Our most recent findings reveal that oleic acid (OA; 18:1n-9), the main olive oil's monounsaturated fatty acid, can suppress the overexpression of HER2 (erbB-2), a well-characterized oncogene playing a key role in the etiology, invasive progression and metastasis in several human cancers."

and

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17134970

ABSTRACT

"CONCLUSIONS: i) These findings reveal that the omega-3 PUFA ALA suppresses overexpression of HER2 oncogene at the transcriptional level, which, in turn, interacts synergistically with anti-HER2 trastuzumab- based immunotherapy. ii) Our results molecularly support a recent randomized double-blind placebo-controlled clinical trial suggesting that ALA may be a potential dietary alternative or adjunct to currently used drugs in the management of HER2-positive breast carcinomas. iii) Considering our previous findings demonstrating the <<HER2 upregulatory actions>> of the omega-6 PUFA linolenic acid (LA; 18:2n-6) and the <<HER2 down-regulatory actions >> of the omega-3 PUFA docosahexaenoic acid (DHA; 22:6n-3) and of the omega-9 monounsaturated fatty acid oleic acid (OA; 18:1n-9), it is reasonable to suggest that a low omega-6/omega-3 PUFA ratio and elevated MUFA levels, the two prominent <<fat features>> of the <<Mediterranean diet>>, should be extremely efficient at blocking HER2 expression in breast cancer cells."

RB

[R.B.]

Just bringing it back up for new members in case of interest

[hutchibk]

Thanks for the bumps, as I had lost track of this thread and it is a very important one! I want to switch my entire diet (at least home cooked diet) to the healthiest aspects of Med/Greek. I have always loved the food, the freshness, the oils, etc...