Marie,
Sorry I am just catching up with this post, have been away for a bit... My sister has had WBR and then multiple CyberKnife treatments (a brand of Gamma Knife, I believe) at Beth Israel Deaconess Medical Center in Boston. The CyberKnife was very effective, then a new 2-3 tiny mets would show up in new location after 2-3 months. Lesson: definitely follow-up MRI should be scheduled every 2-3 months, until there is a consistently long period when no new mets show up -- then perhaps a longer stretch between MRIs.
When she maxxed out on CyberKnife, she shifted to Tykerb+Xeloda. That didn't work for her, so she was started on Temodar+Sorafenib. That worked well for about 9 months, but she lost too much weight from medication side effects. She is now on CPT-11 (a.k.a Irinotecan)+Avastin (along with Herceptin) -- that combo has been very effective for a number of months now, and her doctors are monitoring closely with MRIs.
Hopefully the GammaKnife treatment will do the job for your husband, but just in case you need to look for something else down the road, I wanted you to know that there are other potential options out there.
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Emmay - My sister's history:
6/03 Her2+,ER-PR-Breast Cancer, IIb, 7/03 lumpec. rt.brst
9/03 Begin chemo-AC+T
2/04 Mastectomy for local recurrence
3/04 Begin Herceptin, 5/04 Rad to mastec.site
9/04 Recurring Headaches=brain mets
10/04 Craniotomy #1 - rem. 3 br. mets, 11/04 WBR
2/05 Begin Lapatinib(Tykerb) Clinical Trial
5/05 Craniotomy #2 - remove largest brain mets
7/05 Stereotactic Radiation to 2-3 brain mets
10/05 - 3/07 CyberKnife Radiation Treatments for sm brain mets as they arose. Cont. Herceptin
5/07 Begin Temodar+Sorafenib for brain mets
2/08 Begin Tykerb(Lapatinib)+Xeloda for br. mets
5/08 MRI&Biopsy shows ext.new disease, some necrosis
5/08 Begin CPT-11(Irinotecan)+Avastin for br.mets
6/08-4/09 MRIs look great! cont. Herceptin
3/09 Stop CPT-11, brain CTclear-some nausea,backpain
4/09 Scans=pleura,liver,bone mets.
New Rx Herceptin+Avastin+Xeloda
6/09 new Rx Carboplatin+Herceptin
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