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Old 12-26-2012, 01:14 AM   #1
tammymarie1971
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I think I found the culprit to my anxiety

Hi again ladies, I was looking up the meds that this palliative care doctor prescribed for me...... I am sooooooo mad. I don't even think I asked for anything for sleep...Zopiclone 7.5mg 2 tablets a night is what I was given the date on the bottle is Nov 17. Now with the ammonia issue I have trouble remembering and processing everything, but I am pretty sure I have only been taking 1 a night, but I am scared!! What I read about this drug is awful, you can look it up yourselves if you want, but it says it should only be given in the short term 7-10 days and that daytime anxiety withdrawl can start happening after 3-4 weeks of usage!!! WHY WOULD A DOCTOR PRESCRIBE THIS??? No wonder this feeling would hit me right out of the blue!! DARN IT! I don't need this crap in my life.....
No one told me this...not the pharmacist either...Now wouldn't someone say something... I was prescribed ativan at the same time..who wouldn't say "Hey this isn't a good idea"? How am I supposed to trust this doctor to safely "keep me comfortable"? when he is adding to my problems?
Any suggestions on what to do? I guess I could take half a pill for a few nights and ween myself off...I don't know..I just know that the anxiety that creeps up behind me around dinner time is enough to do me in where I want relief NOW! It is really scary...
Anyway at least I know I am not going crazy, but I AM MAD!

Thanks for listening again,
Tammy
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Dx'd Dec'01 while 6mos preg. with #4. child (30yrsold)Mastectomy/AC chemo/radiation/ Recur:Mar'04 liver mets: 3 taxol/herceptin /liver resection/3 taxol/herceptin. Cured?
Recur: May'05 spine & Hip. New onc
treatment in Mexico Feb'06-Mar-06
back to Mexico June/July '06
Currently on herceptin/Zometa/Femara-recently added navelbine
Switched to arimidex Nov'06
ovaries removed June '07
ca15-3 in May'06 was 102
ca15-3 summer of '07 holding steady at 23!
ca15-3 slowly rising Dec & Jan 36, 38, 41 and Feb was 36
Feb '08 Liver, lung & Brain scan NED... bones are stable with even a couple spots gone. as compared with '06 scans
May '08 ca 15-3 is 55. Treatment is zometa, vinorelbine, herceptin and aromasin.
No signifcant changes.
Feb'09 Started Xeloda with herceptin..no more hormonals
Feb'09-June'09 tumor markers coming down again from 155 to 84
May'09 blood clots in lungs vena cava filter put in..Heparin shots daily for now.
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Old 12-26-2012, 09:54 AM   #2
chrisy
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Re: I think I found the culprit to my anxiety

Tammy,
I would not be surprised to hear that your fruit basket of meds might be interacting, enhancing, detracting and compounding each other's effects. I would go back to your pharmacist and/or doctor, whichever one you can get to first, and have them go over all the drugs checking for side effects and interactions that might be causing the problems. You may find that "less is more", but probably need help to figure that out.

Good luck, Tammi
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 12-26-2012, 10:32 AM   #3
'lizbeth
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Re: I think I found the culprit to my anxiety

TammyMarie,

You are experiencing something that many of us have gone through and learning you have to be your own best advocate. It is helpful when you have a family member or friend to help track the meds - prescriptions can really start piling up.

I stopped taking all my meds (I was NED but getting over cellulitis in the reconstructions) at once, the benadryl, the pain relievers, etc.

It took 10 days to get them processed out of my system enough to feel more "normal". What a relief it was.

Yep, reading about pharmaceuticals can be scary. The doctor prescribes medication because at the time they believe the benefits will weight the risks.

I like Chrisy's advice that "less is more" . . .

I think your liver is maxed out currently on processing toxins. Have you tried acupunture? I received it at Balboa Naval Medical Center and it was such a blessing. I got many of the same benefits of medications and none of the toxic side effects. It can help with more than pain relief, they can bring your stomach and spleen meridian back into harmony to help with worry, and the liver meridian to help with anger - If you can find an experienced LAc in your area or a DOM (doctor of oriental medicine) it is worth a try.

I love that you are so determined to get better!
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Diagnosed 2007
Stage IIb Invasive Ductal Carcinoma, Pagets, 3 of 15 positive nodes

Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"

Additional treatments:
GP2 vaccine, San Antonio Med Ctr
Prescriptive Exercise for Cancer Patients
ENERGY Study, UCSD La Jolla

Reconstruction: TRAM flap, partial loss, Revision

The content of my posts are meant for informational purposes only. The medical information is intended for general information only and should not be used in any way to diagnose, treat, cure, or prevent disease
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Old 12-26-2012, 10:33 AM   #4
KsGal
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Re: I think I found the culprit to my anxiety

Im sorry to hear about the medication issues. I agree, we are all on so many different medications at any one time, it would be a good idea to just sit down with the doc and/or pharmacist and go over them one by one. I take lorazepam for anxiety and help with sleep and don't have issues with it so far. I used to be able to sit down and kind of figure out my own meds out, but its far beyond that now and I definitely need help with mine. I hope you are able to figure it out, and just keep being direct and ask "why???" was this prescribed for me if you need to know why. Big hugs to you!
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Diagnosed in October 2011 Stage IV with metastasis to liver.
January 2012 after double mastectomy, started taxotere, carboplatin and herceptin.
Clear.
December 2012 was diagnosed with five brain mets, and had whole brain radiation.
Around July 2014 two mets in brain, one a residual spot and one new one growing in size. Received Cyberknife on both areas
Clear/NED
April 2015 remain NED
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Old 12-26-2012, 11:54 AM   #5
BonnieR
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Re: I think I found the culprit to my anxiety

I can't say I'm surprised. You are on quite a drug overload. Each one may have a purpose but together can interact badly. Plus, the stress on your liver to process it all And each doctor adds to the mix. As has been said, you need a manager for all of this
But don't stop any drug abruptly on your own. That could cause more problems. Get someone to work with you on a schedule
Sadly, when we are at our lowest state is sometimes when we most need to be our own advocate. When we are dealing with unfamiliar situations. It would help so much if you could enlist someone to work with you in this capacity
It will get better YOU will get better. Keep the faith
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Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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Old 12-27-2012, 06:25 AM   #6
sarah
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Re: I think I found the culprit to my anxiety

Hello,
Someone and that may be you, should figure out the interactions between all the drugs you're taking and which ones you can safely drop.
I've taken 1/2 a zopliclone from time to time for years with no bad experience in fact I like it better than other sleeping pills because I wake up without feeling drowsy but then I only take 1/2 and only periodically and I'm not taking as many drugs as you (only some for my heart).
Only you know how you feel and you're obviously very anxious and there are certainly things to do to help this. Have you tried meditation or at least finding time to be quiet and calm? I'm not a new agey person at all but I do know that being able to do yoga deep breathing and meditation and learning to calm yourself are extremely important and helpful. I find reading extemely calming and wonderfully distracting - if you don't enjoy reading, try listening to audio books. TV can add to anxiety so I suggest less of that. ~Walking and exercise, if you're strong enough, can be helpful. ~Read a book in bed at night and I think you'll find it will help you sleep without drugs.
take deep breaths and concentrate on your breathing, visualizing your breath.
I'm sure if you search for relaxation tips, you'll come up with something helpful but you have to really try and concentrate.
take care
hugs and love
sarah
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Old 12-28-2012, 04:24 AM   #7
karen z
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Re: I think I found the culprit to my anxiety

I think Chrisy and others are right and have given you good advice. I would talk to your pharmacists immediately about the weaning issue and have a talk with your doc.

I think you will feel better when you are off so much (and perhaps the wrong things) and then, if you do need something for anxiety, you might be able to get "a little" help with that.
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Old 12-28-2012, 06:52 AM   #8
Del
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Re: I think I found the culprit to my anxiety

Hi Tammy,
This sounds like a very high dose of Zopiclone! I am also prescribed Zopiclone at 7.5mg, but I am only to take a HALF a pill when needed. Two pills at a time seems very high! And recently I have been breaking my pills into thirds, and that does the trick as well. I only take them when needed, not every night. And I haven't found any side effects, addiction probs. I wake up without any drowsy feelings, although I always have a terrible taste in my mouth. I would have an immediate discussion with your doctor (or pharmacist in the meantime). I have no idea if the dosage is based on weight, or anything else (I'm around 140 lbs on a good day . Hope you find a solution soon!
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diagnosed April, 2007, age 36 - stage IV, mets to liver; ER+ (slightly), PR-, HER2+
MRM April 26, 2007
started chemo May 25, 2007 - Taxotere and Herceptin
finished chemo Oct 2007, continue on Herceptin for life, also on Tamoxifen
MRI in Jan 2008 shows no evidence of cancer in liver - NED!!
recurrence in left axilla nodes April 2010
now highly ER+, still HER2+
oophorectomy July 2010
start TDM1 (Emilia) trial Sept 2010
it's working!! can still palpate small node in axilla, but remain NED everywhere else
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Old 08-04-2013, 02:45 PM   #9
CarolineC
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Re: I think I found the culprit to my anxiety

I was prescribed zopiclone years ago for fibromyalgia and have mainly taken half a pill every night.

A month ago I picked up my prescription at the local pharmacy (they know what I have been going through with cancer for the last 4 years) and noticed that the pills were a lighter blue. I mentioned it to the clerk and she said they were changing pharmaceutical companies, so I asked if they could print out the ingredients because I have a sensitive system and have a hard time adjusting to different meds-it seems I don't need much of anything to have an effect. I got just 7 pills to try out and had dull headaches, but thought I was just adjusting. Last week I woke up at about 3 am and took another half pill-which I have sometimes done, and I was completely out of it for my bloodwork the next day.

I didn't like how I felt and just looked up zopiclone on wikipedia.org. Wow. If you read it, note the subtitles on carcinogenicity for breast cancer because of the drug having an adverse effect on the immune system. I also noted that "patients with liver disease eliminate it slower than normal patients and in addition experience exaggerated pharmacological effects of the drugs" -I have Gilbert's Syndrome which I'm believing is not such a benign liver condition. I have also been experiencing an "out of it" feeling constantly and am wondering if it was also interacting with Letrozole which I take around 8 pm and can also cause dizziness and drowsiness-at least it had a label saying so when I was having radiation at a larger centre and had the pills renewed. The local centre doesn't put that label on the box. I am "only" on metoprolol and zopiclone besides Herceptin, Letrozole and Clodronate. I never thought my little blue pill could be so dangerous. I have now dropped to 1/4 pill nightly and am trying to get off them, and I feel abit more coherent in the morning.

I spoke to the pharmacist when getting the rest of the pills saying that from now on could they please inform me of brand changes and he apologized and said they normally do. I have yet to show them this information. The brand of these pills looks to have less fillers and are abit larger although they are supposed to be the same mg-they feel more potent.

These were the only pills I was on before I was diagnosed and no one has reviewed the prescription with me, at least not in the last 4 years. I thought I was being so careful, checking my anti-cancer meds out and trying to boost my immune system by eating healthy, exercising, stress reduction, etc. and this makes me frustrated.

Tammy, I hope you are doing well and that you have discontinued the pills.
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Dx Age 47 July/09 Stage 2B/3
Left Mast. Aug 09- 1 of 3 positive nodes in axillary dissection (yes only 3)
ER+ 90%, PR+ 20%, HER2+++
4 x AC, 4 x Paclitaxol and H (Neupogen for 7 cycles), Herceptin complete Nov 10
Mar–Apr 2010 25 Rads
Apr 10-Oct 11- Tamoxifen
Oct 11 – 3 cm met to sternum
Oct 11-Letrozole for 3 mths, start Clasteon-bone remodeller
Nov-Dec 11 - Happy 50th Birthday -20 rads to sternum
Jan-April 2012 Taxotere/Herceptin-6 cycles (Neupogen for 5)
Herceptin every 3 weeks-Letrozole added Nov 2012
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Old 08-05-2013, 08:01 AM   #10
sarah
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Re: I think I found the culprit to my anxiety

Hello,
I might have been taking a different drug acutally mine is Stilnox or Zolpidem but I have a feeling that taking any of these drugs too often can be a problem. hope you solve it because not sleeping isn't good either
hugs and love
sarah
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