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Keytruda
It looks like I was approved for Keytruda, starting in the next two weeks. Tucatanib is not going to work out for me, b/c I was just on Tykerb, and because it seems that they are not offering compassionate use.
I hear such terrible things about Keytruda's--and all immunotherapies'---side effects, that I'm very apprehensive about it. The father of a friend of mine was on it for melanoma and he says that it gave him Parkinson's, and I know autoimmune diseases are associated with the drug.
Kadcyla did not work for me; i had to have platelet infusions, and i was so tired i could barely teach. so, i don't know if i would get Keytruda alone. i have brain and lung mets, so i'm not sure if they would put me back on perception.
Anyway, my question is, does anyone here have experience with Keytruda? Especially positive ones? Is there anything I should do, in terms of maintaining my overall health while on it? Seeking information, advice, wisdom, support, as usual, from my wonderful friends here. Love and light to you all!
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Diagnosed 3/26/14 BC Stage 3a ER neg PR neg HER-2+
5 cm tumor in left breast, needle node biopsy positive
Started TCHP 4/25/14 - 6 rounds
Oncologist can no longer feel tumor, after 4th round
Chemo shrunk tumor to less than a mm
Lumpectomy and axillary node dissection 9/3/14
Radiation for 5 weeks, with boost
Herceptin until 4/3/15
CT Scan on 4/27 shows lung mets (lots of little ones on both sides, largest 1.6 cm) STAGE IV
Lung biopsy shows still HER2+++/ER-/PR-
Taxol with Herceptin and Perjeta May, June, July 2015
Lung mets reduced by 50%
Just H&P through Fall 2015
11/15 Progression
Back on Taxol with H&P January 2016
THP no longer working March 2016
Start Kadcyla 3/16 After first treatment, experienced low platelets, tongue turned black, had to have transfusion. Dry cough and shortness of breath for first week, improves over second and third.
4/16 Platelet transfusion after second treatment, blood blisters in mouth. Allergic reaction to platelets.
6/16 Kadcyla not working. Progression to liver, though lung mets smaller.
7/16 Start Xeloda and Tykerb.
11/16 Port infected. Taken out. Have to go off chemo.
1/17 Back on Xeloda and Tykerb
5/17 Tykerb and Herceptin
11/17 Navelbine and Herceptin
12/17 Progression in lungs, liver reevaluated, no progression
1/18 Haloven and Herceptin
2/18 Sloan Kettering consultation
3/18 Brain mets, 16 lesions, largest 16mm
3/18 Cyberknife to 16mm lesion
3/18 Haloven and Tykerb added
4/18 Scan shows all lesions significantly smaller! Some almost gone. Radiation oncologist says she's never seen anything like it
7/18 Brain scan shows progression, w/ with one new lesion. Don't want to do WBR. Will try for tucatinib.
8.15.18 Start Keytruda
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