effect of aspirin on her2 in cervical cancer (???applicable to breast cancer??)

Lani · 05-09-2009, 09:54 PM

Med Oncol. 2009 May 8. [Epub ahead of print]

Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells.

Xiang S, Sun Z, He Q, Yan F, Wang Y, Zhang J.
Department of Biochemistry and Molecular Biology, Key Laboratory of Protein Chemistry and Developmental Biology, Ministry of Education of China, College of Life Science, Hunan Normal University, Changsha, Hunan, 410081, China.
The use of aspirin is associated with a lower risk of many cancer types. However, there are few reports about cervical cancer. The proto-oncogene ErbB2 is overexpressed in cervical cancer, and considered as a therapeutic target. In the present study, we investigated whether aspirin had therapeutic value in cervical cancer and examined the effects of aspirin on the amplification and expression of ErbB2. To investigate the effects of aspirin on apoptosis and proliferation, we tested apoptosis by Hoechst 33258 staining and Annexin V-FITC/PI method; MTT assay and colony formation assay were used to detect proliferation. Induction of apoptosis and inhibition of proliferation were observed in HeLa cells incubated with aspirin. Western blot and immunocytochemical staining showed that aspirin induced a dose- and time-dependent reduction of ErbB2 expression that was due to proteosome-mediated degradation of this protein. To further investigate the underlying mechanism by which aspirin exerts its apoptosis effects, we studied the ErbB2 downstream cell survival signaling pathways and the expression of anti-apoptosis gene Bcl-2. We found that aspirin inhibited the activation of extracellular signal-regulated kinase (ERK) and AKT. The inhibition of Bcl-2 expression was also observed. These data reveal that aspirin significantly induces apoptosis and inhibits proliferation, which maybe via inhibiting ErbB2 downstream cell survival signaling pathways. Taken together, our article describes a novel mechanism of action for anti-tumor activity of aspirin and implicates aspirin as a novel agent for cervical cancer.
PMID: 19424877 [

hutchibk · 05-09-2009, 11:15 PM

Wonder if I should start taking my baby aspirin every day? Guess it couldn't hurt.

Jackie07 · 05-09-2009, 11:46 PM

It shouldn't hurt. Thanks for reminding me of taking my
baby aspirin. I took it for a while for my leg pain - after I finished the small bottle, I completely forgot about it...

05-27-2009, 11:04 AM

I know this is an old thread about Aspirin supression of Erb2 expression. The reason Im re-introducing it is a number of people responded saying they will remember to take their 81mg Aspirin tablet. I remember years back in some of my Pharmacy journals the protective effect of aspirin against colon cancer was mentioned. I beleve the journals stated that the minimum Aspirin dose for colon cancer prevention was one 325mg Aspirin tablet, the standard aspirin tablet. While I cant prove this it might be better to take the higher dosage (325mg) with your doctors approval. of course. This aspirin dosage will still give the protection against heart attack which is the purpose of the 81mg tablet.

Paul

Mary Jo · 05-27-2009, 04:06 PM

I take 325 mg. (1 adult aspirin) every day. When I had my breast reconstruction last June my plastic surgeon put me on 325 mg. of aspirin for 1 month after the surgery. He said I could discontinue it's use in a month but that he takes a full strength aspirin every day (for reasons listed in this study and a few others) and that if I wanted to continue I could and I do.

Mary Jo