I read the same re her2 status and tamoxifen not working. In fact, because of that I refused Tamoxifen and at the time that was the only way to get an AI (aromatase inhibitor). However, I did go to UCLA for a 2nd opinion and the dr. there said that either would be good choice. There was some thought at the time that Herceptin might allow Tamoxifen to work. However, if I was concerned about increased risk of blood clots or stroke then I should consider an AI. This was 3 years ago. I have been on Arimidex. I had wanted Femara but the oncologist wasn't willing to prescribe that.
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