Semi synthetic flavonoid monoHER has been shown in preclinical studies dating back to at least 2003 to prevent heart damage caused by Doxorubicin without reducing its efficacy. It has been speculated that it does so by acting as an antioxidant in the heart.
In the following report, two anti-flammatory drugs belonging to different classes, are also protective in mice:
ketoprofen (an NSAID), dexamethasone (a cortisone).
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice.
Has anyone used one of these 3 drugs (or any other one) to prevent cardiac problems from Doxorubicin or Doxil (as opposed to treating heart damage after the fact)?
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