Update on Joy 10/27

julierene · 11-05-2009, 10:27 AM

I am so glad to hear they are considering her for Avastin. I was going to start Avastin/Ixempra before I became aware of the p53 gene therapy for Li-Fraumeni Syndrome (which I am positive for). So I put everything off, to wait for the 4 week cleansing to start the trial, and the crap moved into my brain. Now I am starting WBR till Nov 20th and hopefully start the trial on Nov 30th. Being that it's brand new, I am pretty scared and excited about it - sounding like it's the perfect solution to a 25 year piece of critical research in the genetic problem I have had all my life, and the life of my family. They have tried to deliver it all sorts of ways, but this way sounds like it will finally work.

Back to the subject, Avastin is one of the drugs my oncologist worked with in breast cancer patient trials and said that he felt it was WAY underutilized in the HER2+ metastatic situation, where tumors were VERY knowingly vascular. He said you should be able to just look at the CT and MRI and see that your disease is very vascular. When you get to the point where Tykerb and Herceptin seem to stop working, some of the older therapies stopped working, and you have limited options left - try Avastin. That is my next line, if I don't get into the p53 trial for some unfortunate circumstance.