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Old 09-30-2015, 02:44 PM   #1
agness
Senior Member
 
Join Date: Aug 2014
Location: Seattle, WA
Posts: 285
Post Breast Cancer Classification in Flux

If you have been paying attention and trying to research anything about this disease you will quickly notice that the staging system is really weird and the types of breast cancer are greater than the four types they keep trying to group everyone into - luminal A, luminal B, HER2, and Triple Negative.

Finally in 2014 one of the main cancer bodies sort of seized on this and have stated, especially in this very early stage of more individualized medicine, the four categories of disease aren't going to cut it.

Those who are triple positive (ER+/PR+/HER2+) are grouped with (HER2+/HR-) all the time in studies and the fact is that we don't get the same treatments nor do we have the same disease responses even when given the same chemo protocol (such as in the case of TCHP where HR-/HER2+ had a slightly greater chance of a PCR but with triple positive you were more likely to have residual cells still).

When we get into genetic testing of live or preserved tumors, or when they test for additional factors influencing metastasis, things like: GATA3, P53, EGR, PIK, etc. and these also change the responsiveness of various chemo treatments.

I found this link about one group that is trying to develop a new classification methology. It seems proprietary to me but perhaps I'm wrong. We might see further development of this system or others in the near future and we as patients should demand it.

Genome-driven integrated classification of breast cancer validated in over 7,500 samples
http://genomebiology.biomedcentral.c...059-014-0431-1
__________________
  • Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall.
  • Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy.
  • 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED.
  • 10/27/15 atypical uptake in right cerebellum - inflammation?
  • 12/1/15 Leptomeningeal dx. Starting IT Herceptin.
  • 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly
  • 3/2016 - stable scan
  • 5/2016 stable scan
  • 7/2016 pseudoprogression?
  • 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT
  • 11/2016 Cyberknife to temporal lobe, HBOT just prior
  • 12/2016 - lesions starting to show shrinkage
  • 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone.
  • Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing.
  • Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.

Last edited by agness; 10-01-2015 at 06:53 AM.. Reason: improving clarity
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classification, genomic, mutations, types of breast cancer

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