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Old 08-25-2010, 11:49 AM   #1
Rich66
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UA 2010 - Is Prostate Cancer an Infectious Disease?

http://www.urotoday.com/61/browse_ca...s06072010.html

UA 2010 - Is Prostate Cancer an Infectious Disease? - Session Highlights


Monday, 07 June 2010
SAN FRANCISCO, CA USA (UroToday.com) - In his state-of-the-art lecture, Dr. Eric Klein asked whether cancer, and in particular prostate cancer, is an infectious disease. He stated that numerous cancers are caused by infections and more cancers are caused by infections worldwide than occur in the US from all causes. There is epidemiological data that suggest there is increased risk of CaP with early sexual activity and increased number of partners, but decreased risk with frequent ejaculation. A prior history of any sexually transmitted disease or prostatitis is associated with increased risk of CaP. Variants in RNaseL and MSR1 are two examples of genetic links to CaP. Xenotropic murine leukemia related virus (XMRV) was first described in 2006. It is a novel retrovirus and a mutation in this gene is associated with CaP. It integrates into the host chromosomes and sits in cancer-associated fibroblasts. XMLV is not an oncogene, but likely integrates into the host to activate an oncogene. XMRV has been found in 23% of CAP tissue samples compared with only 6% of benign tissues. The antibody against XMRV is found in 30% of patients undergoing radical prostatectomy.
SMRV is also found in 67% of patients with chronic fatigue syndrome compared with 3.7% of controls. It suggests it may be transmitted through blood contact. In a monkey model of transmission, it is found in white blood cells and lymphoid tissue. At day 7, it can be isolated in prostate tissue. If left longer, at 5 months it can be found in the epididymis and seminal vesicles. Androgens added to CaP cells in culture stimulate XMRV replication and it was found that there is an androgen response element in the virus. Prostate epithelium is an early target of XMRV, and stroma becomes infected later on. He pointed out that there have been some negative studies as well, due to technical aspects and viral variants, he said. Globally, there are different areas of viral penetration but causality between XMRV and human disease remains to be proven.

Presented by Eric A. Klein, MD at the American Urological Association (AUA) Annual Meeting - May 29 - June 3, 2010 - Moscone Center, San Francisco, CA USA
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