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Old 10-24-2007, 06:27 AM   #1
Hopeful
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Insulin receptor predicts favorable outcome in breast cancer

http://www.breastcancersource.com/br..._28772___.aspx

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Old 10-25-2007, 12:19 PM   #2
TSund
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This looks like a very interesting article, tho I would love it if someone would put it into laymen's terms as far as these different insulin factors.

THX

TRS
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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Old 10-26-2007, 06:28 AM   #3
Hopeful
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Terri, I do not have a medical background, nor the gift of some others on this Board who are good at "translation." However, here is the link to the abstract from which the article was written: http://www.springerlink.com/content/m2712r1197000072/ and the conclusion stated therein (IR = insulin receptor):

"IR is highly expressed in the majority of early stage breast cancers but this expression is not clearly down-regulated in the presence of high insulin levels. Furthermore, high expression of IR is independently and significantly associated with more favorable clinical outcomes. Follow-up intervention research is recommended."

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