Chicken or egg--increased prior breast cancer in newly diagnosed diabetes patients

Am I missing something here? It seems there is also increased diabetes in those diagnosed and treated for breast cancer...



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1: Breast Cancer Res Treat. 2006 Mar 15; [Epub ahead of print] Links

Increased prevalence of prior breast cancer in women with newly diagnosed diabetes.

Lipscombe LL, Goodwin PJ, Zinman B, McLaughlin JR, Hux JE.

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

OBJECTIVE: There is growing evidence of a link between type 2 diabetes and breast cancer, possibly through insulin resistance and/or hyperinsulinemia. Because insulin levels are at their highest prior to the development of diabetes, breast cancer risk may be even greater during the pre-diabetes period. RESEARCH DESIGN AND METHODS: In this cross-sectional study, women aged 55-79 years living in Ontario, Canada, with newly diagnosed diabetes from 1994 to 2002 were identified from a validated, population-based database (N = 82,390). Prior history of breast cancer in this group was recorded from 1964 until their diabetes diagnosis from a linkable cancer registry, and was compared to a similarly aged comparison group without diabetes (N = 411,950). RESULTS: Prior breast cancers were identified in 3.7% of women with diabetes and in 3.1% women without diabetes (odds ratio, OR 1.22, 95% confidence interval, CI 1.17-1.27, p < 0.0001). The mean time from breast cancer diagnosis to diabetes diagnosis was 7.9 years. The likelihood of a breast cancer history remained significantly higher in women with diabetes after adjustment for age, income and physician visits (OR 1.13, 95% CI 1.09-1.18, p < 0.0001). CONCLUSIONS: These results suggest that breast cancer risk may be increased in the pre-diabetes phase and may have implications for screening and prevention strategies. Further studies are required to better characterize the processes that link insulin resistance, diabetes and breast cancer.

PMID: 16538527 [PubMed - as supplied by publisher]

What is to say it is not something about the treatment of the breast cancer that brings on the diabetes--or perhaps weight gain brought on by lack of exercise, fatigue,depression,...??

Thanks Lani.

I have been keeping an eye out for trials like this.

For me at my very amateur level from my reading it is unsurprising if asthma and BC and linked.

I would expect to see links between BC and other inflamatory conditions.

Many of the mechanisms seem to have a communality and interlink.

I have for a long time had a concern as to whether Herceptin trials have controlled for any correlation between heart health and BC - if the drop out due to heart problems, or selection process has also been controlled for any such influence. I sincerely hope so.

Omega threes are acknowledged to lower heart condition risks, AND women with highest breast tissue n3 / DHA EPA had lowest risk of invasive tumours, so it may not be a totally barking concern.

RB.