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Old 06-15-2007, 01:59 PM   #21
tricia keegan
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Nope me neither but thanks Rhonda as I had'nt a clue what it meant!!
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Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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Old 06-15-2007, 02:01 PM   #22
jo50
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Simian line

I don't have the simian line either, but what interesting thoughts and ideas come up here.... Jo.
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Old 06-15-2007, 02:10 PM   #23
mslinda
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No for me.
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Diagnosed 12/23/04
Biopsy 12/28/04
Lumpectomy 1/04/05
IDC, ER-PR-, HER2Neu+++
7mm tumor, Stage 1, Grade 3
6 CAF's
38 Rads
Finished 10/05

"Worry looks around. Sorry looks back. Faith looks up."
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Old 06-15-2007, 03:56 PM   #24
harrie
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don't have one
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*** MARYANNE *** aka HARRIECANARIE

1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen

2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy

2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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Old 06-15-2007, 05:40 PM   #25
Mary Anne in TX
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Not me either!
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MA in TX.
Grateful for each and every day....

Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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Old 06-15-2007, 06:15 PM   #26
fauxgypsy
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nope.
Leslie
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Old 06-15-2007, 06:28 PM   #27
Barbara H.
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No for me
Barbara
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Old 06-15-2007, 06:32 PM   #28
Patricia
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I don't have a simian line but my husband has one on each palm.
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age 37 @ dx 7/21/05: IDC 1.5cm, grade III, Stage 1c, ER /PR+, HER2+,
7/29/05: Partial Mastectomy
dx 8/15/05: Papillary Thyroid Cancer
9/15/05: Total Thyroidectomy
A/C X 4 DD, 11 weekly Taxol + Herceptin, + 9 mos Herceptin Alone, 36x Rads, Lupron, Aromasin
7/29/07: 2 years NED :)
8/6/07 Oopherectomy (Lupron no more! :-)
Aromasin & Estring plus Synthroid and supplements
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Old 06-15-2007, 06:46 PM   #29
Chelee
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Nope.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 06-15-2007, 07:21 PM   #30
juanita
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None for me either!
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dxd 9-04, lumpectomy,
st 1, gr 3, er,pr-, her2 +,
2 tac,33 rads,6 cmf
1 yr herceptin,
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Old 06-15-2007, 07:59 PM   #31
sassy
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Well, I guess I'm one of the 4%. Right hand....

I had no idea what it was either, thanks Rhonda.

Good to "see" you Gina. Let me know if you are coming this way anytime.
________
Portable Vaporizer Review

Last edited by sassy; 08-22-2011 at 09:18 AM..
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Old 06-15-2007, 08:19 PM   #32
Bev
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Hi there, No simian lines. Simian as in ape? Seem to be typing in bold today. Site has changed. Love the slide show. BB
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Old 06-16-2007, 09:12 AM   #33
Donna
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incomplete answer

Hi Gina,

I didn't answer it correctly the first time - I have the simian lines in both hands.

Donna

P.S. never have liked the "simian" reference!
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Old 06-16-2007, 09:44 AM   #34
sarah
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No, I don't have it.
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Old 07-16-2007, 01:33 AM   #35
Gina
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Lightbulb Follow-up on Simian line on Palm(s)

First, thank the more than 30 of you who kindly indulged me with excellent responses to my research on the simian line...for those of the old-timers who know me...smile...you were quite correct to suspect that it may (or may not) have something to do with her-2 mediated disease.

I became fascinated with the concept while reading a non-fiction book on the evolution of the human hand and the various comparisons to the hands of other primates and other non-handed animals. Most of the other primates most closely related to humans have simian lines. Most modern humans, do not.

Humans of Asian descent, including "gypsies" (who migrated out of the India/Tibet/China region give or take about 11,000 years ago would be considered of Asian Decent as would many modern day Persians, various Eastern Europeans, especially Romanians and Hungarians and Poles, and several other populations decended from Asia or who were heavily invaded by the the Huns --have higher incidences of simian lines than the general population. Modern Asians today have the highest concentration of simian lines, about 13 % of the population versus around 3 to 4 % for caucasions. Most modern Asians, today, though, it is believed have LOWER incidences of breast cancer than other populations, but it also may be that we just don't have access to the real numbers, say in China or North Korea, or remote parts of India, or war-torn Afghanistan.

However, there are some studies that indicate folks from some of these ancient Asia-migrated areas have breast cancer rates higher than other populations. Many of these folks have higher incidences of her-2 mediated breast cancer than other folks, especially descendents from eastern Europe.

The line can apparently be genetically passed on, as a trait, like blue eyes or red hair, and is usually passed on as a TRUE simian line as it is in my family: My mother has one on her left hand, I have one on my left hand and my youngest sister has one on her left hand. To have 3 people in one room all possessing simian lines at any given time is exceedingly rare. Now that you know what a Simian line is, you will start looking for them and understand what I mean. One of the reasons I didn't immediately say what a simian line was is that most likely if you didn't know what it is...you most likely would not have one...tease...tease...smile...because if you have it, it is sufficiently rare that most likely over your life, someone would have pointed it out to you as happened to me when my Korean friend noted it, with surprise--as I was not obviously Asian, one day years ago.

Alternatively, especially in cases of "partial" simian lines or near true simian lines, hormone levels in the womb may be responsible, most particularly, high levels of testosterone. This is the same phenomenon, varying hormonal environment of the womb, that causes the fingerprints of even IDENTICAL twins to be slightly different as the final "imprinting" --if you will --of the lines occurs during gestation and are not set in stone as ordinary genetic traits generally are (again, things like Blue eyes, Green eyes, or straight versus curly hair, or type A Rh-negative blood --if found in one identical twin, will equally be found in the other, not so of finger and palm prints).

In the non-fiction book on the subject, folks born with simian lines of any kind, have been correlated by physicians to have more health-related difficulties and more UNUSUAL kinds of health-related difficulties their whole lives, although most tend to live out normal or even LONGER than normal life spans. In the case of my family. my mother (71), myself (43), and my youngest sister (39), all of whom possess strong, clean simian lines that slice through our left palms, have dealt with serious and life-threatening illnesses our whole lives, while ironically, my middle sister (41), who has no such line, is the tower of health in our family.

I remember reading that Tony Blair (who has a simian line on both hands) struggled off and on during his time as Prime Minister with various health issues...hmmmmm...makes one really want to look at Vice President Cheney's hands, no?? smile.

Anyway, other parts of my research had shown a moderate connection with testosterone hitting a female fetus during early parts of gestation and later correlations to ER- PR- her-2 3+ mediated disease.... That made me want to find easy ways to see if any hormonal NEGATIVE gals who were her-2 very positive could have possibly been exposed to testosterone during gestation and the simian line was one tell-tale factor, as well as being left-handed. Some gals on the site who were her-2 positive had also noticed that someone in their extended family had had autism, others schizophrenia, and this can sometimes be connected.

Some of you will remember my work on RH negative blood groups and all of this ties into the same research as the blood type would also define a genetic "type casting" if you will of someone who may be slightly more genetically prone to her-2 mediated disease--although, in my theory, of course, it takes two things, pre-existing genetic vulnerability and surendipitous contact with the offending organism--still unproven, of course--this is only hypothesis still.

I guess my big question now would be to Donna and Sassy. Are you both hormonal negative that is ER- and PR- as I am or do you have some hormonal element to your illness? By any chance do you have RH negative blood types...I am RH negative type A.

And Patricia, I would also be interested to know your hormonal signature and something about the general health of your husband with the two simian lines, like Tony Blairs. Also, is your husband RH negative?

If any one out there, after reading this posting, has her-2 mediated disease and a family member or someone they know with a Simian line, I would be delighted to have you post something to this thread. Every comment is useful. I love the feedback and yes, to many of you who posted just to say, "hi", I too have really missed you all during the past year, a hearty HELLO to each and every one!!!

Godspeed,
Gina
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Old 07-16-2007, 06:54 AM   #36
DonnaD
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Sorry no for me also.
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Donna
Crystal Lake, IL
Diagnosed 8/4/06 at age 54
Lumpectomy 8/30/06
Stage llA, grade 3, ER/PR-, Her2++
1.7 cm tumor, 1+ lymph node out of 9
Completed 4 A/C, & 4 Taxol with Herceptin
36 rads completed 5/16/07
Mammograms, 7/07 clear
fractured ribs in radiated area 10/07
Finished Herceptin 12/27/07
Mammogram,CT,tumor markers 1/08 - small lung nodules in radiated area, repeated tests 3/08 stable
Mammogram,CT ,tumor markers 6/08 stable
NED 2 years!!
3 years !!!
4years!!!!
4 years, 10 months and 8 day NED, calling it 5 years!!!
Official 5 years 8/30/2011
8/31/ 2012 - 6 years!!!!!!
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Old 07-16-2007, 08:28 AM   #37
doh2pa
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None for me!
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Donna
Diagnosed 2/04 - Invasive ductal - no clean margins
node negative - er+pr+, her2++
Mastectomy 4/04 - 4 rounds AC
9/05 - mets to liver treated with carbo/ixabipelone/herceptin
3/06 - complete remission
9/06 - new liver mets, starting Taxotere/Herceptin
1/07 -Liver mets stable, staying on Herceptin
5/07 - Liver, lung progression - starting T/X
12/07 - Liver, lung progression - starting weekly Navilbene/Herceptin
4/08 - Liver progression - started Abraxane, Carbo, Tykerb and Herceptin
7/08 - Liver Progression - started Gemzar, Avastin and Tykerb
10/08 - Liver progression - starting Doxil
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Old 07-16-2007, 08:55 AM   #38
StillHere
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Simian Line

Nada for Simian line
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04/05 Onset 49, DCIS, solid, Hist 2/3, Nucl 2/3, 7cm R Brst
04/05 E & P + HER2+++
05/05 Mediport
05/05 Cytoxan & Adriamycin every 3wk x4
08/05 Taxol every 2wk x 4, Herceptin every wk x1yr
10/05 Bilat Mast - my Choice
10/05 3/19 lymph nodes Pos, Stage IIIa
11/05 Rad x 37 Rx, R Brst & Axcilla
02/06 Herceptin stopped (L vent HF 40)
03/06 Started & Stoped Arimidex after 2 mos.-QOL side effects
05/06 Started Tamoxafin
06/06 Bilat Free Flap Reconstruction
12/06 Cardiomyopathy reversed-HF normal
01/07 Bilat Saline Implants
07/07 CA 27-29 steadily rising from 28 in 12/06 to 46 in 7/07
07/07 PET Scan NED, but inflamation at prev surg site.
09/07 Started Femara
10/07 CA 27-29 down to 39
06/08 CA 27-29 down to 32
09/08 Lg joint pain & QOL side effects from Femara, will live w/ to keep CA markers within normal range.
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Old 07-16-2007, 09:23 AM   #39
lexigirl
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Nope, me either.

Lexi
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Old 07-16-2007, 04:42 PM   #40
Andrea Barnett Budin
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Wink

I have no simian line, but -- I see (w/help from Rhonda's http) that I have a heart line and a head line. What's the other line between the two? And my left hand has a vertical line going through all three lines.

I'm sitting here reading all your posts, fascinated and staring at my palms... I guess I never really looked before. Any answers to my questions re addl lines????????? ANDI

Gee Gina, you are a most intriguing personality! Nice to make your acquaintance...
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Andi BB
'95 post-meno dx Invasive LOBULAR w/9cm tumor! YIKES + 2/21 nodes. Clear mammo 10 mnths earlier. Mastec/tram flap reconst/PORT/8 mnths chemo (4Adria/8CMF). Borderline ER/PR. Tamoxifen 2 yrs. Felt BLESSED. I could walk and talk, feed and bathe myself! I KNEW I would survive...

'98 -- multiple mets to liver. HER2+ 80%. ER/PR- Raging, highly aggressive tumors spreading fast. New PORT. 9 mnths Taxotere Fought fire w/fire! Pronounced in cautious remission 5/99. Taxotere weekly for 6 wks, 2 wks off -- for 9 mnths. TALK ABOUT GRUELING! (I believe they've altered that protocol since those days -- sure hope so!!)
+ good old Vit H wkly for 1st 3 yrs, then triple dosage ev 3 wks for 7 yrs more... The "easy" chemo, right?! Not a walk in the park, but not a freight train coming at 'ya either...

Added Herceptin Nov '98 (6 wks after FDA fast-tracked it for met bc). Stayed w/Vit H till July '08! Now I AM FREE! Humbly and eternally grateful for this life-saving drug! NED since '99 and planning on keeping it that way. To hell w/poor prognosis and nasty stats! STOPPED VIT H JULY '08...! REMAIN STABLE... Eternally grateful...Yes is a world & in this world of yes live (skillfully curled) all worlds ... (e e cummings) EVERY DAY I BEAT MY PREVIOUS RECORD FOR # OF CONSECUTIVE DAYS I'VE STAYED ALIVE. Smile KNOWING you too can be a miracle. Up to me and God now...
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