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Old 07-16-2007, 10:30 PM   #1
bbwentworth
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Location: Champlin, MN
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Question Tykerb or Tykerb/Abraxane side effects

Hello,

I am experiencing increasing neuropathy (tingling/numbness) in arms, lower legs & FACE and increase in blood pressure (154/110), despite meds. I am wondering if I can share any similar side effects with my Dr, my Abraxane was held today, I have to go back to re-check BP tomorrow. The fun never ends!
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Orig DX ...Oct 02 AC 3 mos, Taxol 3 mos, Herceptin Trial 52 weeks, Mets to liver DX Dec 2005 Herceptin, Taxotere, Xeloda, switch to Carbo ( Hand/Foot Syndrome), Partial Response, June 2006, Mets DX Dec 2006, tried RFA, Add'l Mets to liver & spine Jan 2007 Herceptin, Gemzar, Aredia. Abraxane- Switch to Avastin, Aredia, Abraxane- switch to Tykerb, Aredia, Abraxane. Current status...No progression, No shrinkage.
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Old 07-17-2007, 05:25 AM   #2
Sheila
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Beth
I am on Abraxane with Taxol and Herceptin and my B/P is also rising...running 150 /84...but my usual runs 110/66....I monitor it daily, but it seems that many on Avastin need to go on a low dose B/P Med to keep the pressure down so as to remain on the Avastin. Chrisy who is on Tykerb/Avastin just went on B/P meds ...hopefully she will respond.
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Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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