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Old 09-25-2008, 11:42 AM   #1
runtolive
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new trastuzumab-dm1 trial beginning

for patients who have failed tykerb.

http://www.clinicaltrials.gov/ct2/sh...ow_locs=Y#locn

run to live
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Old 09-25-2008, 12:08 PM   #2
chrisy
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Cancer Treatment Centers of America

Hmmmm....

I see that they are participating in this trial (this is the Zion IL location and perhaps others).

So, controversial - perhaps, but not clueless!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 09-25-2008, 01:18 PM   #3
runtolive
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what are u thinking chrisy. i dont understand
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Old 09-25-2008, 01:19 PM   #4
runtolive
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they dont have ucsf listed for this trial yet either..
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Old 09-25-2008, 05:13 PM   #5
chrisy
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Just a random comment based on a discussion on a different thread. CTCA was noted as "controversial" not this drug, trial or anything else!

Recently there was a thread on CTCA started by Rich66 (you may not have seen this) on whether or not they were a "serious" (my words) place - as they are more embracing of integrative modalities. Some of the comments were about an apparent lack of solid research being done there - comments which may have been a bit unfounded.

Just good to see that they apparently ARE serious enough to be participating in this trial. Which actually seems right up their alley - minimal toxicity.

Re not seeing UCSF on the list; I've concluded the lists are not accurate so you should ALWAYS check. UCSF is STILL not on the list for the trial I've been in since February! But I think I'll ask my trial coordinator about it on Monday.
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 09-26-2008, 09:12 AM   #6
runtolive
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hopefully genentech can get this trial enrolled quickly and approved later next year..

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