HonCode

Go Back   HER2 Support Group Forums > Articles of Interest
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 01-30-2020, 05:19 PM   #1
Nguyen
Senior Member
 
Join Date: Nov 2005
Posts: 256
Over come resistance to Neratinib with Affinitor.

Given that Neratinib has been out not that long ago, and already resistance to it has developed as in

Neratinib resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4.

https://www.ncbi.nlm.nih.gov/pubmed/28152547

The below news is welcome. Essentially Neratinib and Affinitor could overcome this resistance.

Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers

https://www.sciencedirect.com/scienc...835?via%3Dihub
Nguyen is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On

Forum Jump


All times are GMT -7. The time now is 02:48 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007
free webpage hit counter