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Old 07-06-2013, 10:44 AM   #1
Lani
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Join Date: Mar 2006
Posts: 4,757
Thumbs up hydrophilic status may increase progression-free survival in IBC

I mean't hydrophilic statins, but don't know how to correct the subject line!!!


Br J Cancer. 2013 Jul 2. doi: 10.1038/bjc.2013.342. [Epub ahead of print]
Statin use in primary inflammatory breast cancer: a cohort study.
Brewer TM, Masuda H, Liu DD, Shen Y, Liu P, Iwamoto T, Kai K, Barnett CM, Woodward WA, Reuben JM, Yang P, Hortobagyi GN, Ueno NT.
Source
1] Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA [2] School of Medicine, Eastern Virginia Medical School, Norfolk, VA 23501, USA.
Abstract
Background:Some studies have suggested that statins, which have cholesterol-lowering and anti-inflammatory properties, may have antitumor effects. Effects of statins on inflammatory breast cancer (IBC) have never been studied.Methods:We reviewed 723 patients diagnosed with primary IBC in 1995-2011 and treated at The University of Texas MD Anderson Cancer Center. Statin users were defined as being on statins at the initial evaluation. Based on Ahern et al's statin classification (JNCI, 2011), clinical outcomes were compared by statin use and type (weakly lipophilic to hydrophilic (H-statin) vs lipophilic statins (L-statin)). We used the Kaplan-Meier method to estimate the median progression-free survival (PFS), overall survival (OS) and disease-specific survival (DSS), and a Cox proportional hazards regression model to test the statistical significance of potential prognostic factors.Results:In the multivariable Cox model, H-statins were associated with significantly improved PFS compared with no statin (hazard ratio=0.49; 95% confidence interval=0.28-0.84; P<0.01); OS and DSS P-values were 0.80 and 0.85, respectively. For L-statins vs no statin, P-values for PFS, DSS, and OS were 0.81, 0.4, and 0.74, respectively.Conclusion:H-statins were associated with significantly improved PFS. A prospective randomised study evaluating the survival benefits of statins in primary IBC is warranted.British Journal of Cancer advance online publication, 2 July 2013 doi:10.1038/bjc.2013.342 www.bjcancer.com.
PMID: 23820253
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Old 08-27-2013, 12:06 PM   #2
Kat
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Join Date: Jun 2007
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Re: hydrophilic status may increase progression-free survival in IBC

Have recently read that statins improve survival for inflammatory bc, but dangerous for other bc's. any thoughts, anyone? am on statins, but temporarily suspended use till i'm more comfortable about the below pasted study.
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