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Old 08-26-2015, 05:12 PM   #1
Lani
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Join Date: Mar 2006
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Exclamation how obese breasts predispose to breast ca?BEWARE fat injections for reconstruction

PUBLIC RELEASE: 26-AUG-2015
Stiffer breast tissue in obese women promotes tumors
CORNELL UNIVERSITY


ITHACA, N.Y. - Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how obesity changes the consistency of breast tissue in ways that are similar to tumors, thereby promoting disease.

The study of mice and women shows obesity leads to a stiffening of a meshwork of material that surrounds fat cells in the breast, called the extracellular matrix, and these biomechanical changes create the right conditions for tumor growth.

The findings suggest clinicians may need to employ finer-scale imaging techniques in mammograms, especially for obese women, to detect a denser extracellular matrix. Also, the results should caution doctors against using certain fat cells from obese women in plastic and reconstructive breast surgeries, as these cells can promote recurring breast cancer.

"We all know that obesity is bad; the metabolism changes and hormones change, so when looking for links to breast cancer, researchers almost exclusively have focused on the biochemical changes happening. But what these findings show is that there are also biophysical changes that are important," said Claudia Fischbach, associate professor of biomedical engineering and the paper's senior author. Bo Ri Seo, a graduate student in Fischbach's lab, is the paper's first author. The study is a collaboration between Cornell's Ithaca campus and researchers at Weill Cornell Medical College and includes Dr. Andrew Dannenberg, professor of medicine.

Fat tissue in obese women has more cells called myofibroblasts, compared with fat tissue in normal-weight women. Myofibroblasts are wound-healing cells that determine whether a scar will form. All cells secrete compounds to create an extracellular matrix, and they remodel and grab onto this meshwork to make tissue. But when myofibroblasts make an extracellular matrix, they pull together - the action needed to close a wound - stiffening the tissue.

But "these are cells in our body regardless of injury," said Fischbach. In obese women, there are more myofibroblasts than in lean women, which leads to scarring and stiffening without an injury in the extracellular matrix. Tumors also recruit more myofibroblasts than are found in healthy tissue, which also leads to stiffer extracellular matrix.

Many obese women get regular mammograms but signs of disease don't show up because detecting their dense extracellular matrix between the fat cells requires a finer-scale resolution. The findings "may inspire use of higher resolution imaging techniques to detect those changes," said Fischbach. "Right now, people don't look for stiffer extracellular matrices as a clinical biomarker."

During plastic or reconstructive surgery following mastectomy in breast cancer patients, doctors may inject adipose stromal cells from obese donors to regenerate tissue. "What our data suggests is that it is really important where these cells are being taken from," Fischbach said. "If you use these cells from an obese patient, they are very different and you may actually be driving malignancies if you implant them."

###

The study was funded by the National Institutes of Health, the National Science Foundation, the Breast Cancer Research Foundation and the Botwinick-Wolfensohn Foundation at WCMC.

Cornell University has television, ISDN and dedicated Skype/Google+ Hangout studios available for media interviews.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
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Old 08-26-2015, 08:24 PM   #2
thinkpositive
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Join Date: May 2014
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Re: how obese breasts predispose to breast ca?BEWARE fat injections for reconstructio

Makes me wish I didn't have fat injection when I had my reconstruction! I am not overweight so perhaps the risk isn't as high but I wouldn't have had this procedure at all based on this article.

Thanks for passing this information on Lani
__________________
8/2013 Diagnosed IDC Left Breast ER-/PR-/HER2+ Stage 3C, DCIS ER+/PR+/HER2- Right Breast (54 yr)
8/2013 PET/CT scan shows mass in uterues and suprclavicular nodes
8/20/13 Begin 6 rounds TCH chemo, Perjeta added for rounds 4-6
9/2013 After 1st round of chemo, mass in neck and breast no longer able to feel
11/2013 Hysterectomy, mass from PET/CT scan not cancer (adenomylosis)
12/2013 Finished chemo
1/2014 Double mastectomy with chest expanders
1/2014 Pathology report from surgery and SNB show complete pathological response!
3/2014 Finish IMRT radiation
8/2014 Fat transfer to radiated breast
8/2014 Completed 1 yr of Herceptin
10/2014 exchange surgery expanders removed implants placed
6/2015 3D nipple and areola tattoos
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Old 08-27-2015, 10:39 AM   #3
Lani
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Re: how obese breasts predispose to breast ca?BEWARE fat injections for reconstructio

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