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Old 12-30-2019, 05:41 AM   #1
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Combination treatment reduces breast cancer development in mice

Adding a medication used to treat epilepsy, bipolar disorder and migraines to a blood pressure medicine reversed some aspects of breast cancer in the offspring of mice at high risk of the disease because of the high fat diet fed to their mothers during pregnancy.

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Old 12-30-2019, 10:45 AM   #2
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Re: Combination treatment reduces breast cancer development in mice

Interesting

For those that might be interested. There are proteins called histones that are very electropositive chemically. Genes tend to be very electro-negative. Cells including cancer cells have both pro growth and anti growth genes. The cancer cells wrap the antigrowth genes with histone protein to keep them inactive. The Histone protein acts like a very tight blood pressure cuff. The body fights back by putting an electronegative acetyl group (vinegar) under the "cuff"to decrease the pressure on the gene. The cancer cell fights back by using a deacetylase enzyme to remove the pesky acetyl group that is loostening the histone protein. Histone deacetylase inhibitors prevent this.

This potential anti-cancer action of the anti-siezure drug Depakote (valproic acid) has been know n for decades but little is ever said about it. The drug is extensively used to treat epilepsy because it has an odd action. It is effective against both petit mal epilepsy and grand mal epilepsy. Usually if a siezure drug helps one type of epilepsy it makes the other kind worse, Not Valproic acid. A lot of people take this drug. Im curious if their cancer development rate is signifcantly lower. Some people are on the drug for life

Paul
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