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05-31-2010, 01:13 PM
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#1
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Senior Member
Join Date: Feb 2010
Posts: 151
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taxotere vs taxol
what is the difference in these 2 drugs? I start a new regime tomorrow. I will get herceptin and taxotere. I have seen several people talk about taxol but not much about the taxotere. Any one else have this and have any idea why this recipe is used? I just completed 4 treatments of adrimyicin and cytoxen. I am dose dense and get neulasta shot after each treatment.
i also got to see the movie Living Proof last night. it was awesome. I so appreciate Dr. Slamon's dedication and his familie's sacrifices for his research.
DX jan 19,2010 Invasive Ductal Carcinoma,
31 nodes removed, 17 positive
modified radical masectomy on Right side
mets to just above collar bone ( 2 nodes showed in PET)
started chem mar 22
april 19 chemo delayed 2 weeks- hopsitalized for what was thought infection
in surgical spot... but was not
start herceptin and taxotere june 1 Dose Dense
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05-31-2010, 02:52 PM
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#2
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Re: taxotere vs taxol
I think that they are the same family of drugs. As you can see, I took Adriamycin and Taxotere together (ugh) and then taxol and herceptin with Carboplatin added. Sounds as if you're being heavily treated as I was. So far, it has worked for me. ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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05-31-2010, 05:20 PM
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#3
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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Re: taxotere vs taxol
Taxotere and Taxol are in the same family of drugs (Taxanes). However, I have heard that Taxotere is a bit more effective. Don't worry about the difference, there's not much if any (except Taxotere may be a bit better and that's what you're getting).
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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05-31-2010, 05:44 PM
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#4
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: taxotere vs taxol
Becky's right. There's a study done in 2003 at UT-San Antonio that showed better results from Taxotere. But the study was sponsored by the company that produces Taxotere. So there might be some bias there.
I think the doctors just switch the two 'taxanes' back and forth to see which one is more tolerable to the patient.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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05-31-2010, 10:21 PM
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#5
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Senior Member
Join Date: Feb 2010
Posts: 151
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Re: taxotere vs taxol
Thank you for the information. I will see how it goes tomorrow. they told me it would take 3 hours for the Taxotere and 1 and half hours for the herceptin since it is the first time and i will be monitored for any kind of reaction. I am excited to start getting herceptin. I saw on our news tonite that there is a new vaccine coming out in the next 1-2 yrs that will prevent breast cancer from starting and stop the cancers that are already active. Research is so awesome.
__________________
Mammogram Sep 21, 2009 everything good and clear
DX jan 19,2010 Invasive Ductal Carcinoma, Grade 2 Age 56
modified radical masectomy on LEFT side 29 Jan 2010
2.7 cm 18/31 nodes
mets to just above collar bone ( 2 nodes showed in PET)
ER- PR - / Her2 +++ (IHC) Stage 111 C
ki-67 60% nottingham score 7
A/C chemo mar 22,2010 DD
herceptin & taxotere DD june 1,2010
finished taxotere july 12, 2010
finished herceptin 16 May 2011
PET Scan 9 Aug 10, cancer in neck is gone! NED
33 Rads completed 1 Oct 2010
PET/CT Scan 6 Jan 2011 NED
PET/CT Scan 3 Aug 2011
MUGA 59% 3/22/10 -63% 9/23/10 - 51% 1/4/11 - 55% 2/17/11 - 50% 8/3/11
26 Aug 2011 NED
20 Feb 2012 NED
5 Mar 2012 PORT OUT
12 July 2012 DIEP breast reconstruction
23 Aug 2012 NED
15 Nov 2012 new breast tweeked and natural breast uplifted and implant added
17 Feb 2013 NED
27 mar 2013 lipo suction to add fat cells to new breast in hopes for needed adjustment.
"Don't spend your time worrying about when or how you are going to die, spend your time figuring out how you are going to live today". ~Elizabeth Edwards.
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06-01-2010, 02:07 AM
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#6
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Senior Member
Join Date: May 2010
Location: Ireland
Posts: 271
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Re: taxotere vs taxol
Candlegranny,
You are so lucky to be starting your treatment. I envy you, and wish you all the best also! I got biopsy results and cancer is back, had lump on chest checked and its positive. Lots more since. Told its very agressive and must be treated immediately- then get appointment for scans - in a months time! Rang consultant but he says we have to wait for scans. cancer epidemic where I live, also health cutbacks. Had mastectomy 2008, then a/c, taxol, and 1 year of tyverb. Less than a month after I came off the tyverb the lump appeared on my chest. Now remaining breast hot and painful, also backpain, had mri in Nov, wear and tear they told me then. Have gone from using paracetamol to tramadol . Has anyone else been left waiting this long and been ok?
Delaney.
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06-01-2010, 04:45 AM
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#7
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Senior Member
Join Date: Sep 2005
Location: Melbourne Victoria
Australia
Posts: 330
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Re: taxotere vs taxol
Hi
They are both extracted from the Pacific yew tree. One is from the leaves and the other from the bark. When I was doing my honours in Chem in 1993, the girl whose desk was next to me was trying to work out the structure of taxol so it could be synthesised.
Cheers
Jackie (down under)
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06-01-2010, 05:00 AM
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#8
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Senior Member
Join Date: Jan 2008
Location: Evergreen, Colorado
Posts: 454
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Re: taxotere vs taxol
Dear CG,
Thank you Jackie for the info regarding the UT - San Antonio study. I never was certain why I received taxotere vs taxol.
CG....I did want you to know that I received the taxotere + herceptin combo. It did wonders for me and knocked back my stage IV liver met for over a year. I later went back on yet another form of the taxane "family" called Abraxane. The Abraxane worked wonders again.
So...it appears that the taxanes are very powerful against Her2+ cancer.
Wishing you a speedy and event free treatment. If you have any questions about the process or side effects feel free to ask away!!!
Best of luck....Lori
__________________
2007
Oct - Diagnosed - Stage IV 5 c.m. IDC - Left Side er/pr- Her2+++ Node + 2/14 - Single Liver Met Double Mastectomy Nov - Begin T+H 2008
Feb-Complete 6 cycles- T&H- NED
March - Continue - Herceptin Only
April - Rads for 6 weeks
2009
Continue Herceptin - Continue NED
April - Recurrance- 3 cm. Liver Met
May - Cryosurgery
June - November - Abraxane + Herceptin
Aug - PET/CT - CTC = 0 Back to NED
2010
January - Continue NED
July - Recurrance - 3 cm Liver Met CTC=1
August - Cryosurgery #2
August - November Navelbine
November - Back to NED - End Navelbine
2011
Feb - Recur - 4 cm Liver Met - Same Left Lobe
March Surgery it is -Couldn't get a clean margin
July - Confirmed continued liver involvement
August - Begin Herceptin + Tykerb
October - Mixed results from H+T
Add Abraxane + H + T - Nov - April
2012
January PET Scan - It's working!!
April - Back to NED
July - Recurrance
August - Begin TDM-1 Trial (Taxol + TDM-1)
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06-01-2010, 05:48 AM
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#9
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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Re: taxotere vs taxol
Hi Delaney, I just noticed your post as I also am in Ireland.I'm very sorry to hear of your recurrance but I'm sure you'll benefit greatly from the info and support on this site. I'll send you a private message as don't want to hijack this thread
Candlegranny, just wanted to wish you luck tomorrow and hope you find it tolerable. I found the first treatment took ages though so allow extra time!
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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06-01-2010, 06:47 PM
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#10
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Senior Member
Join Date: Jun 2007
Location: Bergenfield, NJ
Posts: 121
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Re: taxotere vs taxol
Taxotere is a cousin of Taxol per my onc. I'm on Taxotere plus my Herceptin (BFF) since Feb. 2 weeks on 1 week off. This coming Friday (june4) is Cycle 5, week 2. Then CT Scans on Sat., June5th. The nasty side effect? Nails falling off :-( blood collecting under the nails and all turning white and seems like they're falling off :-( same with my toenails. Also, excessive eye tearing :-(
But every one is different. I use tea tree oil and it helps. Good luck with your new cocktail. You'll be in my thoughts and prayers.
Gemma
__________________
My love to you all
Gemma
____________________________________
Dx July03 at 35
Rt,breast lump.,1 node+
ER+(98%)ER-, grade3
A/C 4rounds,Rad for 38 days
Tamoxifen 2004-05
Recurrence Feb.2006, radi double mastectomy canceled bec. of mets, StageIV lungs mets
Her2+++, BRCA negative
Taxol/Herceptin six rounds of Taxol from April06.then Herceptin alone til May07. Started Tykerb/Xeloda in Jun07-Sept.07 bec of progression of the lympnodes. Navalbine/Herceptin Sept.07 to April 08 due to progression . Gemzar/Hercptin Apr08.June08 Brain MRI showed Brain Mets.CraniectomyAug.1,08, tumor removed completely
completed 20 wbrt!
Started Doxil 10/31/08 (monthly) and weekly Herceptin
Ixempra on 2/13/09
due to multiple hepatic mets
will have Herceptin as well.
Radical rt.breast Mastectomy June2009.
Ixempra/Herceptin 11/06/09--increasing right axillary lymphanenopathy and enlarging left upper lobe nodule :-(
Taxotere/Herceptin 3/5/10,more liver mets, lungs, lymphnodes. 2 weeks on, one week off...
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06-01-2010, 07:14 PM
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#11
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Senior Member
Join Date: Feb 2010
Posts: 151
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Re: taxotere vs taxol
i have the eye tearing already from the A/C. they told me today it could worsen. what is the tea tree oil and how is it used?
I had my first herceptin and taxotere today. it was an all day thing in case of a reaction. I had no reactions thank God. i also asked about my tumor margins ... he gave me two differnent numbers but the Tm was 28 something. He said that was good and meant the chemo was doing what is is supposed to do. it was a long day, tomorrow I go for my neulasta shot so i will ask my nurse more about those numbers.
__________________
Mammogram Sep 21, 2009 everything good and clear
DX jan 19,2010 Invasive Ductal Carcinoma, Grade 2 Age 56
modified radical masectomy on LEFT side 29 Jan 2010
2.7 cm 18/31 nodes
mets to just above collar bone ( 2 nodes showed in PET)
ER- PR - / Her2 +++ (IHC) Stage 111 C
ki-67 60% nottingham score 7
A/C chemo mar 22,2010 DD
herceptin & taxotere DD june 1,2010
finished taxotere july 12, 2010
finished herceptin 16 May 2011
PET Scan 9 Aug 10, cancer in neck is gone! NED
33 Rads completed 1 Oct 2010
PET/CT Scan 6 Jan 2011 NED
PET/CT Scan 3 Aug 2011
MUGA 59% 3/22/10 -63% 9/23/10 - 51% 1/4/11 - 55% 2/17/11 - 50% 8/3/11
26 Aug 2011 NED
20 Feb 2012 NED
5 Mar 2012 PORT OUT
12 July 2012 DIEP breast reconstruction
23 Aug 2012 NED
15 Nov 2012 new breast tweeked and natural breast uplifted and implant added
17 Feb 2013 NED
27 mar 2013 lipo suction to add fat cells to new breast in hopes for needed adjustment.
"Don't spend your time worrying about when or how you are going to die, spend your time figuring out how you are going to live today". ~Elizabeth Edwards.
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