Vitamin D thread -Please use this for your Vit D info.

[R.B.]

I just posted two responses - references to new published research papers and they are no longer visible - hopefully they will reappear . . .

Happily they have just reappeared . . .

Sometimes we appear to be in 'Scary Times' as to right to rational open debate . . . hence my happily irrelevant comment . . . in this case

[R.B.]

Vitamin D is essential to development in utero and early years, thus it makes evolutionary sense that breast tissue would have an affinity for vitamin D, and accumulate it particularly in pregnancy. A new study considers such issues.

It is open format so the PDF can be downloaded for free.

https://cancerpreventionresearch.aac....full-text.pdf

Endlessly depressing that it is such an uphill battle to get more focus on the role of vitamin D and wider nutrients in breast cancer.

Without the nutrients they need cells cannot function optimally - that is an evolutionary inheritance imperative.




Vitamin D as a potential preventive agent for young women's breast cancer
Sarah M Bernhardt, Virgina F Borges and Pepper Schedin
DOI: 10.1158/1940-6207.CAPR-21-0114


Abstract

Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear pre-clinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating pre-clinical data to efficacy in humans. While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation. Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development. We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer.

[R.B.]

Time is valuable - I have been posting here for around 16 years - (where did the time go . . .)

Not sure what is happening but another new post has disappeared just after I posted it . . . hopefully will reappear but anybody have any idea why that is happening . . . if a moderation issue surely I can be trusted after 16 years of contributions!

A link and comment on this paper - so nothing controversial - time and brain space consuming to have to worry about informational posts disappearing . . . reentering the site to check a few times etc

Many thanks

https://cancerpreventionresearch.aac...-0114.full.pdf

It did reappear a few minutes later . . . ????!!!

[Nguyen]

RB,

The same posting problems (and log-in irregularity) happens often to me the last several months. It's not a moderation issue, I don't think. Usually I need to wait the next day to see posting appears normally. But you could sort of get around by clicking either "next thread" (or "previous thread") then go backward (or forward) to the thread of your posting, then you will see your new post.

I believe the problem is due to "data caching" (temporary storage of data to local server and/or hub server) to reduce network traffic. Also it might be related to "vbulletin" forum software.

To see your post normally (immediately), make the post using one internet connection mechanism (such as local wifi) and view it using a different connection mechanism (such as cellular). The two different mechanisms generate two IP addresses which by-pass caching scheme.

Nguyen