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Old 04-15-2011, 02:04 PM   #1
ginnyg898
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Did chemo put you into menopause?

When I was diagnosed at age 41 with BC my Oncologist said that I most likely would be forced into menopause by the chemo since I was most likely close to it anyway (my mom and grandma started in their mid-forties).

Since I was diagosed last August and went thru chemo I have only had 2 periods, both of which were long and very heavy. I keep asking my dr. if there is any tests they can run just to confirm if I am in fact in menopause; his answer is always that I am.

I do have some menopausal symptoms, such as hot flashes, but I also get the typical PMS symptoms whenever I am due.

If anyone has any experience with this please let me know...there is a lack of information out there
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41 Years Old
Dx w/IDC in August '10
No family history
ER+/PR-/HER2+
2.2cm tumor/Stage 2A
No node involvement
Tested negative for BRCA 1/2
Participated in a UCLA clinical trial testing TCH and/or Lapatinib in stage 1/2/3 bc patients that can be removed by surgery.
Underwent neo-adjuvant therapy to shrink tumor prior to surgery.
1st Surgery date: 2/16/11
Pathology report indicated ADH/DCIS in margin.
2nd Surgery: 3/21/11
Clean margins!
Started radiation: 4/11/11
Completed radiation: 7/8/11
1st post-surgical mammogram: 8/16/11 - CLEAR!
6 Weeks of Tamoxifen - Failure to Respond
Started Lupron/Arimidex: 8/29/11
Herceptin until September '11

Recurrence - August 2018
Same profile - ER+/PR-/HER2+
Undergoing neo-adjuvant therapy prior to surgery;
Gemzar, Carboplatin, Herceptin & Perjeta
Chemo through the end of 2018...
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Old 04-15-2011, 02:43 PM   #2
Becky
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Re: Did chemo put you into menopause?

I was 45 when diagnosed. I had my period the same day I had my first chemo (AC) that night (I was due to have it). I had my second period about a week late or so and, like you, it lasted 3 weeks and was so heavy I almost considered a diaper. After that, I did not have a period again.... I thought I was done.... but NO, six months after my last chemo, I started up again. The first one was like the last one, very heavy but not as long (10 days or so) and I started menstrating as usual. I did get my ovaries removed to stop for good about 2 months after that because Tamoxifen and I did not get along well and I am ER+ but PR- so I thought an AI would work better.

My onc also told me that I was "done" but I wasn't and was closer to the menopause age because by the time I was done with chemo, I had turned 46 (and my mom was late with menopause - 54) so I probably wasn't that close to it. I felt a bit bad to complain because I got "late" herceptin starting 4 months after my last chemo (wasn't available prior to that for me) and I had a "late" Herceptin buddy who was in my boat. She was 33 and desperately wanted to have a baby but she never got her period back ever so I didn't complain that I did. It didn't seem right.

You can get a test for LH and FSH but do not let them do just that. Have them test your estradiol level too. That is very important.
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Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 04-15-2011, 05:12 PM   #3
KDR
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Re: Did chemo put you into menopause?

Chemopause (or chemo-induced ovarian failure).
Karen
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Graves Disease, became Euthyroid via Radioactive Iodine, June 2001.
Thyroid Eye Disease. 2003. Decompression surgery in 2009; eyelid lowering surgery in 2010.
Diagnosed: June 2010, liver mets. ER-/PR+10%; HER2+++.
July 2010: Begin Taxol/Herceptin. Eliminate sugar from diet. No surgery or radiation.
January 2011: NED
April 2011: Progression in liver only. Other previous affected areas eradicated. Stop Taxol/Herceptin after 32 infusions.
May 2011: Brain MRI: clear.
May 2011: Begin Tykerb daily, Xeloda twice per day for one week on, one week off, and Herceptin.
November 2011: Progression in liver. All other tumors remain eradicated.
December 2011: BEGIN TRIAL #09-093 Taxol, MCC-DM1 (T-DM1), Perjeta.
Trial requires scans every six weeks, bloodwork and infusions weekly.
Brain MRI: clear.
January 2012: NED. Liver mets, good riddance!
March 2012: NED. Developed SMA (rare blood clot) in intestinal artery and loss of sight in right eye due to optical nerve neuropathy. Resolved when Taxol removed this month.
Continue Protocol of T-DM1 weekly and Perjeta every 3 weeks.
May 2012: NED.
June 2012: Brain MRI: clear.
June-December 2012: NED.
December 2012: TRIAL CONCLUDED; ENTER TRIAL EXTENSION #09-037. CT, Brain MRI, bone scan: clear. NED.
January-March 2013: NED.
June 2013: Brain MRI: clear. CEA upticking; CT shows new met on liver.
July 3, 2013: DISASTER STRIKES during liver ablation: sloppy surgeon cuts intercostal artery and I bleed out, lose 3.5 liters of blood, have major hemothorax, and collapsed lung requiring emergency resuscitative thoracotomy, lung surgery, rib rearrangement and cutting deep connective tissue, transfusion. Ablation incomplete. This life-saving procedure would end up causing me unforgiving pain with every movement I make, permanently, otherwise known as forever.
July 26, 2013: Try Navelbine/Herceptin. Body too weak after surgery and transfusion. Fever. CEA: Normal.
August 16, 2016: second dose Navelbine/Herceptin; CEA: Normal. Will skip doses. Watching and waiting.
September 2013: NED, Herceptin only. CEA: Normal. Started Arimidex.
October-November 2013: NED. Herceptin and Arimidex. CEA, CA125, 15-3: Normal.
December 2013: Something brewing. PET lights up on little spot on liver; CEA upward trend, just outside normal. PET and triphasic liver scan confirm Little Met. Restart Perjeta with Herceptin, stay on Arimidex. Genomic sequencing completed for future treatments, if necessary.
January 2014: Ablate Little Met on the 6th. Happy New Year.
March 2014: Brain MRI: clear. PET/CT reveal liver mets return; new lung mets. This is not funny.
March 2014: BEGIN TRIAL #10-005 A(11)-Temsirolimus plus Neratinib.
April 2014: Genomic testing indicated they could work, they did not. Very strange drug combo for me, felt weird.
April 2014: Started Navelbine and Herceptin. Needed something tried and true, but had significant progression.
June 2014: Doxil and Herceptin.
July 2014: Progression. Got nothing out of it. Brain: NED.
July 2014: Add integrative medical hematologist-oncologist to my team. Begin supplements. These are tumor-busting, immune system boosters. Add glutathione, lysine and taurine IV infusions every three weeks.
July 2014: Begin Gemzar, Herceptin & Perjeta. Happy.
August 2014: ECHO perfect.
January 2015: Begin weekly Vitamin D Analog infusions. 25 mcg. via port.
February 2015: CT: stable.
April 2015: Gem working, but not 100%. Looking into immunotherapy. Finally, treatments for the 21st century!
April 2015: Penn Medicine. Dendritic cell immunotherapy.
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Old 04-15-2011, 05:13 PM   #4
ginnyg898
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Re: Did chemo put you into menopause?

Thanks for the info Becky!

I can understand how much tougher it would be if I wanted to have more children; fortunately we are done. For me this about trying to figure out what is going on with my body...Chemo blazes a trail, as you know
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41 Years Old
Dx w/IDC in August '10
No family history
ER+/PR-/HER2+
2.2cm tumor/Stage 2A
No node involvement
Tested negative for BRCA 1/2
Participated in a UCLA clinical trial testing TCH and/or Lapatinib in stage 1/2/3 bc patients that can be removed by surgery.
Underwent neo-adjuvant therapy to shrink tumor prior to surgery.
1st Surgery date: 2/16/11
Pathology report indicated ADH/DCIS in margin.
2nd Surgery: 3/21/11
Clean margins!
Started radiation: 4/11/11
Completed radiation: 7/8/11
1st post-surgical mammogram: 8/16/11 - CLEAR!
6 Weeks of Tamoxifen - Failure to Respond
Started Lupron/Arimidex: 8/29/11
Herceptin until September '11

Recurrence - August 2018
Same profile - ER+/PR-/HER2+
Undergoing neo-adjuvant therapy prior to surgery;
Gemzar, Carboplatin, Herceptin & Perjeta
Chemo through the end of 2018...
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Old 04-15-2011, 05:16 PM   #5
ginnyg898
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Re: Did chemo put you into menopause?

@KDR: If you dont mind me asking, how old were you when you completed chemo?

Congratulations on your NED! So awesome...
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41 Years Old
Dx w/IDC in August '10
No family history
ER+/PR-/HER2+
2.2cm tumor/Stage 2A
No node involvement
Tested negative for BRCA 1/2
Participated in a UCLA clinical trial testing TCH and/or Lapatinib in stage 1/2/3 bc patients that can be removed by surgery.
Underwent neo-adjuvant therapy to shrink tumor prior to surgery.
1st Surgery date: 2/16/11
Pathology report indicated ADH/DCIS in margin.
2nd Surgery: 3/21/11
Clean margins!
Started radiation: 4/11/11
Completed radiation: 7/8/11
1st post-surgical mammogram: 8/16/11 - CLEAR!
6 Weeks of Tamoxifen - Failure to Respond
Started Lupron/Arimidex: 8/29/11
Herceptin until September '11

Recurrence - August 2018
Same profile - ER+/PR-/HER2+
Undergoing neo-adjuvant therapy prior to surgery;
Gemzar, Carboplatin, Herceptin & Perjeta
Chemo through the end of 2018...
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Old 04-15-2011, 07:02 PM   #6
Jackie07
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Re: Did chemo put you into menopause?

My period stopped after the 2nd chemo infusion. I was 43 1/2. There were tiny spotting off and on for perhaps 6 months. I did not experience serious menopausal problems. Because of other health issues and the fatigue caused by the treatment, I really couldn't tell the difference.

After another full-dose of chemotherapy for recurrence at age 47, I was sure that I became permanently menopausal. But my doctor continued to give me Tamoxifen. Even after I had undergone hysterectomy/oophorectomy, he wrote me a note after my 6-month check: "Just want to be sure that you are still on Tamoxifen."

I then looked up the literature on PubMed and saw that Tamoxifen is effective even after menopause...
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Old 04-16-2011, 12:33 AM   #7
Trish
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Re: Did chemo put you into menopause?

I was 46 and pre menopausal when diagnosed. Had no periods and did have hot flushes after chemo but when I was considering Arimidex (for which you have to be in menopause) I consulted a gynacologist who did an ultrasound and decided there was still some ovarian activity. Hence I had an oopherectomy prior to starting on Arimidex.
Trish
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5/2004 (R) 30mm bre gr3 infiltrating ductal ca 16/18nodes er (2+) pr (3+) HER2 (3+)
6/2004
6 cycles(FEC), Oct 40 rads, Tamoxifen
5/2006
oopherectomy, Arimedex
12/2006
liver mets largest 9cm
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Herceptin,
3/2007
Taxol + Herc
1/2008
Herc alone
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Liver and bone mets prog.Abraxane continue Herceptin,Tykerb,Femara and Zometa
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Probable liver progression and increased neuropathy. Xeloda with Tyk+Herc. Zometa 6 weekly.
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10/2011 liver mets prog.Herc, 3 Tykerb +2mg decodron daily,Zometa
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Old 04-16-2011, 02:28 PM   #8
tricia keegan
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Re: Did chemo put you into menopause?

I was 46 and my chemo stopped my periods almost straight away.
When I finished my Onc did an Estradiol test and felt I was in menopause but warned my period could possibly re start even a year later. I decided to have my ovaries removed and take arimidex as I was highly triple positive and really did'nt think Tamox was for me, so far I'm almost six years out so happy with my decision
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Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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Old 04-17-2011, 12:43 PM   #9
Ellie F
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Re: Did chemo put you into menopause?

I was 50 when diagnosed. Had 2 periods whilst on AC then nothing further.
Ellie
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Old 04-17-2011, 12:51 PM   #10
Paty
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Re: Did chemo put you into menopause?

I was diagnosed at 43, almost 5 years ago. My periods have showed on and off very rarely, last one just last week. I have probably have about twelve of them since my last chemo. Have no idea when they will stop for real. Symptoms, I believe the symptoms I have are more of menopause rather than the normal ones before/after the period. I have not paid to much attention to it and have not discussed this with my doctor lately.
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Dx. June 30th, 2006 at age 43
Lumpectomy rt breast
2.2 cm tumor, 13 nodes all negative
ER-PR+,her2+++
6 FAC
32 Rads
Dx. Lung fibrosis due to radiation
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Old 07-13-2011, 03:57 AM   #11
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Re: Did chemo put you into menopause?

At age 39, my last period occurred Aug. 19, 2010 which was also the date of my 1st chemo. I completed chemo Dec. 2010. I had the LH and FSH testing done and have been informed that I'm post menopausal and my cycle will not return. My numbers were FSH=136 & LH=57.8. WooHoo!Additionally, I have a family history of early menopause. I showed signs of being in menopause prior to chemo such as hot flashes. I pray that I'm truly done because I don't desire to have additional children and I'm enjoying not having to deal with a monthly cycle.
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6/14/2010 - Self discovered Lump; Age 39
6/24/2010 - Biopsy results confirm breast cancer
Right breast, invasive ductal adenocarcinoma
HER2neu positive, BRAC I & II negative
7/8/2010 - Lumpectomy right breast, sentinel lymph node biopsy, & port-a-cath installed on left
Stage II, Size 3.2cm, Clear Nodes, Clear Margins
8/19/2010 - Chemo begins - Taxotere, Carboplatin, Herceptin & Tykerb all simulanteously; ALTTO trial arm 4
9/9/2010 - Chemo dose #2
9/30/2010 - Chemo dose#3
10/21/2010 - Chemo dose#4
11/11/2010 - Chemo dose#5
12/02/1010 - Chemo dose #6 - WooHoo, it is complete!
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02/18/2011 - Completed radiation treatment (33 rounds)
08/04/2011 - Completed Herceptin & Tykerb
09/30/2013 - ultrasound guided biopsy (following annual MRI)
10/1/2013 - new cancer in left breast. 6mm discovered via MRI
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Old 07-13-2011, 07:15 PM   #12
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Re: Did chemo put you into menopause?

Went straight to chemopause, but was 48, nearly 49 at the time I began chemo. My mother was in her early 50s when she reached menopause, so I probably went into menopause a year or two early due to the ACTH.
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Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara

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I think I just might hang around awhile....

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Old 07-13-2011, 11:17 PM   #13
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Re: Did chemo put you into menopause?

I had just turned 40 when diagnosed, I went into menopause after my second AC.
I have had my bloods checked every 4 months to check that I was in menopause as I was taking Arimidex, bloods showed Estrodial below 3 and FSH high each time ..........fast forward 6 months, 2 3/4 years since going into menopause and my period has returned, so far I've had 2 very normal periods a month apart, now taking tamox, bloods show I'm not in menopause any more.
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Old 07-14-2011, 04:04 PM   #14
flynny
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Re: Did chemo put you into menopause?

I was 34 dx and I had my first AC tx and then I never got my period back until a year and a half. My doctor kept telling me after the year mark, if you haven't had it already, you probably won't get it back, but I did. It was very heavy the first 2 and I have been charting them since (November 2009). They are all over the place, except for the past 5 months, they have been about 30 days between each (give or take). I was always a 28 day cycle, so its interesting the difference. And they are much, much lighter! I hope this helps. I will have been on Tamoxifen for 3 years this November.
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Jan '07 felt lump (PCP "thought" it was a cyst)
Nov '07 "bloody nipple discharge" (OB-GYN "thought" I had fibrocystic breasts and told me to take 400 IU's of Vitamin E)
Note: Mother was dx w/BC in 2004 (ER/PR+ & HER2+) & mets to brain April 2007 (she passed away June 17, 2008)
2/1/08: Biopsy Dx: DCIS (age 34)
2/22/08: Surgery R-side Mast
2/28/08: 1st Path Rpt Dx: IDC 1.8cm tumor & DCIS 2.1cm
2nd Path Rep DFCI - IDC (0.9cm) & DCIS (2.1cm)
Stage 1b/Gr 3; ER+(5%), PR+(2%), HER-2+++
5/5 nodes NEG; Clear Margins
Chemo: AC 4 rnds (1st one 3/31/08) finished 6/2/08
TH (Taxol/Hercepin) 12 weeks (1st one 6/25/08) finished 9/8/08
Herceptin 9 mos (every 3 weeks) finished 6/8/09
BRCA 1/2 NEG
Bio: Age 39, married to James 1999, 2 boys 12 & 10 yo
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Old 07-18-2011, 05:59 PM   #15
Kmswilson
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Re: Did chemo put you into menopause?

I am 36 and have always been very, very irregular. Since starting chemo, I've had three periods in a row, 28 days apart, during my off-week from chemo. My husband wonders how messed up my body must be to finally regulate while on all this chemo! I asked my oncologist, and he said it was opposite what usually happens during cheno, but I should only worry if I had any bleeding between cycles.
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12/27/10 - IDC, rt breast (approx. 15 cm), lymph nodes, age 36. 1/7/11 - stage 4 IDC, extensive liver mets, Bone mets (spine, sacrum, rib, sternum, upper arm), ER-/PR-, HER2+++; 1/12/11 - port, 1/17/11- startweekly Taxol/Herceptin, monthly Zometa
3/8/11- decrease in all tumors, bones healing. 3/11- 3 wks on/1 off Taxol/Herceptin, +Zometa
6/6/11 - decrease in all tumors, healing bones, 2-4 new liver lesions. 3 wks on/1 wk off Taxol/Carbo/Herceptin, +Zometa
7/29/11 - liver progression, others stable; 8/11-drop taxol/carbo, start Navelbine
12/11 - liver progression; begin AC, drop Herceptin;
1/12 - liver enzymes normal, 2/6 results show regression in liver, stable others, but 9 tiny brain mets (largest 7 mm). Begin 13 WBRs 2/6; 2/29-start Tykerb, 3/7, start Xeloda
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5/2012- brain MRI shows all lesions gone except 1, 2mm shrinking!
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Old 07-19-2011, 02:39 AM   #16
sarah
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Re: Did chemo put you into menopause?

Hello,
I think chemo and particularly the anti-estrogen drugs can give you PMS reactions, also depression can also be a cause - depression isn't just about being sad but over reacting to things - anger, sadness but heightened.
If the PMS symptoms are creating problems with your family and friends, consider going on an anti-depressant for a while until the treatment is over or you feel calmer, etc. It doesn't have to be forever - that was my worry. A friend told me I was depressed during chemo and I laughed at her having never been a depressive person but then she pointed out the other symptoms and then I spoke to the chemo doctor about it and she said yes and suggested I do a mild one for a short period of time, which I did and I stopped getting angry quickly or frustrated and felt much better. and then I stopped and life is normal again. Mine was called Paroxetene but I'm in France so might be different. I'm glad I did it because during chemo my sweet husband once said to me "I don't know what to say anymore, everything seems to be the wrong thing"
take care
health and happiness
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Old 07-20-2011, 06:24 PM   #17
ArmyMomLisa
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Re: Did chemo put you into menopause?

I turned 45 a week after my first chemo. Had my usual period the next week, and then nothing since (that was in February) My onc too told me that ifyou don't have it again after a year, it's probably not coming back. (That was the case w/ a friend of mine - she is 3 years out from chemo and hasn't had it again.)

The hot flashes are plenty and annoying, but in some odd way make me feel a bit more 'normal' after all of this. Even if it is chemo induced, it's something that was coming my way anyway - a proper, normal womanly right of passage so to speak - and I am craving normal desperately now after finishing chemo and wanting to be my old (or is it new and improved??) self. :-)

Been on Tamox for a few weeks now, so hard to tell what symptoms may be left from chemo and what may be from that.
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age 45

11/17/10 diagnosed (at age 44) after mammogram w/ 3 cm, Stage 1,Grade 3 IDC in left breast Er/Pr+, Her2+, BRCA neg.
12/14/10 lumpectomy
12/17/10 path report results show tumor larger than originally thought from MRI,
1/3/11 Bilateral mastectomy w/ immediate reconstruction (expanders - began fills 4 weeks after surg.)
2/16/11 Began 6 rounds of Taxotere/Carboplatin/Herceptin every 3 weeks
2/18/11 to hospital w/ kidney stone! (Dr. believes from 'shock to my body' of chemo.)
6/2/11 last chemo! Continue Herceptin every 3 weeks til 2/12
6/22/11 Started Tamoxifen
7/5/11 reconstruction surg.
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Old 07-25-2011, 12:20 AM   #18
Pray
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Join Date: Apr 2011
Location: Michigan
Posts: 1,173
Re: Did chemo put you into menopause?

I had blood work that showed after treatment I was in menapause and two months later I told my onc. I was having cramps he checked again and I am no longer in menapause!
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dx 11/12/09 IDCI
Stage 3a
ER 98% PR 80%
Her2 +3
4/12 nodes
6 rounds TCH
Herceptin 12 months 3weeks
Rad. 30 tx
Tamoxifin 6 months stopped
Arimedex stopped 9/12 (side effects)
Aromasin 10/12
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