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Old 11-04-2013, 09:28 PM   #1
qpdawlsmom
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Location: Owasso, OK
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Taxol, Perjeta and Herceptin - need input on next possible treatment plan
Preparing to go round 3 with HER 2, last pet scan revealed a nice lymph node in my sub pectoral region, same side as original cancer. Onc is recommending Taxol in small doses, 1 dose per week x 2 weeks, 1 week off, then another 2 weeks of small dose taxol, with the addition of perjeta and herceptin every 3 weeks. Anyone else have any experience with this protocol? I have had TCH in 2010 plus 6+ weeks radiation amd year of herceptin. Then adriamycin and cytoxin in 2011 and changing over to Tykerb and herceptin, finishing up 2 years in june .. now, 4 months after being off meds and I have cancerous lymph node
Just checking to see if any of you have been down a similar path and what I should expect from the treatment. thank you.
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April 2010 - found lump
4/20/10 - breast biopsy- dx 4/21/10
IDC HER2+ Stage IIa, grade 3
SLN biopsy + lumpectomy 5/4/10
2X Lymph Nodes pos + for microscopic metastasis
ct/pet scan 5/27/10 - 1 lymph node "hot"
TCH 6 cycles - completed 5 cycles, x 3 wks, T&C complete-10/8/10
Radiation, daily x 6.5 wks-complete 12/22/2010
Herceptin completed on 5/22/11
PET/CT 6/15/11 2 nodes + her2
axillary LN dissection 7/18/11 3 removed, 2 were + for IDC
IDC stage 2a grade 3 HER2, ER/PR-
4 rounds Adriamycin/Cytoxin every 2 weeks, complete Oct 2011, 750 mg tykerb daily + herceptin dose every 3 weeks, last PET scan NED
Tyker/Hercpetin ended June 2013
October Pet Scan - positive lymph node in subpectoral region - perjeta/herceptin and taxol regimine....X2 now perjeta/herceptin only
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Old 11-04-2013, 09:40 PM   #2
CoolBreeze
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Re: Taxol, Perjeta and Herceptin - need input on next possible treatment plan
I haven't but good look to you whatever they decide.

Kind of sucks to keep finding it creeping up, but at least it's not in bone or organ yet. I hope they find the right thing to keep it out and kill it dead!!!!
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08/17/09 Dx'd.
Multifocal/multicentric IDC, largest 3.4 cm, associated ADH, LCIS, DCIS
HER2+ ER+/PR- Grade 3, Node Negative

10/20/2009: Right mastectomy, reconstruction with TE
12/02/2009: Six rounds TCH, switched to Taxol halfway through due to neuropathy
03/31/2010: Finished chemo
05/01/2010: Began tamoxifen, the worst drug ever
11/18/2010: Reconstruction completed
12/02/2010: Finished herceptin
05/21/2011: Liver Mets. Quit Tamoxifen
06/22/2011: Navelbine/Zometa/Herceptin
10/03/2011: Liver Resection, left lobe. Microwave ablation, right lobe - going for cure!
11/26/2011: C-Diff Superbug Infection, "worst case doctor had seen in 20 years"
03/28/2012: Progression in ablated section of the liver - no more cure. Started Abraxane, continue herceptin/zometa
10/10/2012: Progression continues, started Halaven, along with herceptin and zometa.
01/15/2013: Progression continues, started Gemzar and Perjeta, an unusual combo, continuing with herceptin and zometa
03/13/2013: Quit Gemzar, body just won't handle it. Staying on herceptin, zometa and perjeta.
04/03/2013: CT shows 50% regression in tumor, so am starting back on Gemzar with dose reduction, staying with perjeta/herceptin/zometa. Can't argue with success!
05/09/2013: Discussing SBRT with Radiology due to inability of bone marrow to recover from chemo.
06/07/2013: Fiducial placement for SBRT
07/03/2013: Chemo discontinued, on Perjeta, Herceptin and Zometa alone
07/25/2013: SBRT (gamma knife) begins
08/01/2013: SBRT completed
08/15/2013: STABLE! continuing with Perjeta, Herceptin, Zometa
06/18/2014: ***** NED!!!!***** continuing with Perjeta, Herceptin, Zometa
01/29/2014: Still NED. continuing with Perjeta, Herceptin. Zometa lowered to every 3 months instead of monthly.
11/08/2015: Progression throughout abdomen and lungs. Started TDM-1, aka Kadcyla. Other meds discontinued. Remission was nice while it lasted.

5/27/18: Stable. Kadcyla put me right back in the barn. I have two teeny spots on my lungs that are metabolically inactive, and liver is clean.

I’m beating this MFer. I was 51 when this started and had two kids, 22 and 12. Now I’m 60. My oldest got married and trying to start s family. My youngesg graduates from Caltech this June. My stepdaughter gave me grandkids. Life is fantastic.
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Old 11-05-2013, 09:52 AM   #3
'lizbeth
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Re: Taxol, Perjeta and Herceptin - need input on next possible treatment plan
I have not had your experience with the cancer creeping back. I'm with CoolBreeze on the amen it is not in any other place.

I like your oncologist's approach using dual targets and small dose Taxol with a break. It sounds easier on you.

Good luck with this - I too hope it kills the cancer dead.
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Old 11-05-2013, 10:18 AM   #4
yanyan
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Re: Taxol, Perjeta and Herceptin - need input on next possible treatment plan
In the same boat here. I was on kadcyla for 5 months and that took care of the subpectoral, internal mammary and axillary nodes which were very small to begin with. Skin biopsy confirmed 3rd recurrence in local skin despite a clean PET which indicate progression. consulted doctor for treatment options, was told perjeta or navelbine with herceptin. Taxol can be dropped once the syptoms goes away and bro kept on perjeta and herceptin. Waiting for insurance approval
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1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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Old 11-06-2013, 05:47 AM   #5
chrislmelb
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Re: Taxol, Perjeta and Herceptin - need input on next possible treatment plan
I think its great if you can do the herceptin/perjeta, good luck getting approval
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Christine

DX Sept 03 age 40 Stage 2B Grade 3 mastectomy (after 2 prior breast conserving surgeries)
"at least" 2.3 cm 3/12 nodes ER+/PR+ Her2+++
8 FEC. Tamoxifen then Arimidex. Ovaries out.
"late" Herceptin for 2 years (18months after chemo) on HERA trial. finished Herceptin Nov 2007.
Multiple bone mets May 2012 and now liver August 2012.
Abraxne, Herceptin and Zometa.
June 2013 Tykerb, Xeloda and Xgeva
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