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03-27-2009, 08:55 AM
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#1
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Senior Member
Join Date: Aug 2007
Location: Newport Beach, CA
Posts: 161
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Resveratrol by Biotivia
Are any of you taking Resveratrol in your vitamin regimen? I don't often watch Oprah, but caught the last 15 minutes this week when Dr. Oz was on and he had green capsules of Resveratrol and said this is an important part of good health. I quickly read the credits (do this in the theatre, too!) and noticed the name Biotivia, so I called the company and he was sending me some info. on it and suggested I take Resveratrol TransMax (500 mg.), which is really expensive.
Yes, red wine is so much more fun to consume. But, as Lani shows, alcohol is alcohol.
Your thoughts on Resveratrol?
Cheers,
Vicki
__________________
Diagnosed 12/03 at age 53
1.5cm tumor, ER-PR-, Her2 3+(rt side)
Stage 1B, Three negative nodes from Sentinel Node Biopsy
Paget's of the nipple, Infiltrating Ductal Carcinoma and DCIS of the rt breast
Bloom-Richardson score 8/9, P53+ 60-70%, Ki-67+ 30-40%
Skin-sparing mastectomy with immediate lat-flap reconstruction and saline implants, 1/04
Chemo: FAC, five sessions every three weeks Feb.-May 04, then switched to HTC weekly for 12 weeks, June-Aug 04
Zometa every 6 months for osteopenia, started April 09
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03-27-2009, 09:00 AM
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#2
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Webmaster
Join Date: Feb 2005
Location: Home of the "Flying Tomato"
Carlsbad, CA
Posts: 2,036
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Vickie,
You may wish to research olive oil and the HER2 gene. Studies show that it is beneficial.
Regards
Joe
__________________
A Proud webmaster to the internet's most informed, educated, COMPASSIONATE and caring group of breast cancer survivors.
Illegitimi non carborundum
My Album
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03-27-2009, 09:54 AM
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#3
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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I asked my cancer nutritionist, and she told me that the jury is still out/it is still not known on how much resveratrol supplements one must consume to have impact on cancer. She said that I should drink grape juice everyday (a couple of glasses). Yes it is caloric, but it tastes good and is much less expensive than the supplement pills.
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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03-27-2009, 10:35 AM
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#4
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Senior Member
Join Date: May 2006
Posts: 3,142
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Resveratrol by Biotivia
Yes. Good quality grape juice has the same good stuff as red wine does. If anyone wants to check out what Dr. Oz said I posted a link to the show on Life Extension with Dr. Oz in the articles section. Some very cool ideas and suggestion where discussed on the show.
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03-28-2009, 10:34 AM
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#5
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Senior Member
Join Date: Aug 2007
Location: Newport Beach, CA
Posts: 161
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Grape juice and olive oil works!
Just had breakfast and put olive oil on my nine-grain toast. As for the grape juice, Hutch, I'm 110# and the extra calories should be okay. (Nice photo! You're workin' it.)
Elaine, when I clicked on your links, there's a lot of info. and I couldn't find the Oz/Resveratrol/cool ideas part. Also, after seeing Joe's note, when I clicked on the olive oil link, all I got as a classmates.com ad and an error message for a website.
I'll "google it."
Thanks to all,
Vic
__________________
Diagnosed 12/03 at age 53
1.5cm tumor, ER-PR-, Her2 3+(rt side)
Stage 1B, Three negative nodes from Sentinel Node Biopsy
Paget's of the nipple, Infiltrating Ductal Carcinoma and DCIS of the rt breast
Bloom-Richardson score 8/9, P53+ 60-70%, Ki-67+ 30-40%
Skin-sparing mastectomy with immediate lat-flap reconstruction and saline implants, 1/04
Chemo: FAC, five sessions every three weeks Feb.-May 04, then switched to HTC weekly for 12 weeks, June-Aug 04
Zometa every 6 months for osteopenia, started April 09
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03-28-2009, 06:07 PM
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#6
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Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
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Vic,
I seem to recall reading an article on E.R. + bc needing to avoid resveratrol if they were E.R.a or E.R. b; I'm sorry I cannot recall which one is not to be in the presence of resveratrol. I'll google it! Just a moment!
Okay, this seems to speak to what I was remembering:
Estrogenic and Anti-estrogenic Activities Endogenous estrogens are steroid hormones synthesized by humans and other mammals; these hormones bind to estrogen receptors within cells. The estrogen-receptor complex interacts with unique sequences in DNA (estrogen response elements; EREs) to modulate the expression of estrogen-responsive genes (17). A compound that binds to estrogen receptors and elicits similar responses to endogenous estrogens is considered an estrogen agonist, while a compound that binds estrogen receptors but prevents or inhibits the response elicited by endogenous estrogens is considered an estrogen antagonist. The chemical structure of resveratrol is very similar to that of the synthetic estrogen agonist, diethylstilbestrol (see figure 2), suggesting that resveratrol might also function as an estrogen agonist. However, in cell culture experiments resveratrol acts as an estrogen agonist under some conditions and an estrogen antagonist under other conditions (18, 19). In estrogen receptor-positive breast cancer cells, resveratrol acted as an estrogen agonist in the absence of the endogenous estrogen, 17beta-estradiol, but acted as an estrogen antagonist in the presence of 17beta-estradiol (20, 21). At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens (17).
Here is the link to the entire page:
http://lpi.oregonstate.edu/infocente...ol/#estrogenic
I post this because triple pos folks like me must be careful about estrogen mimickers. I see you are not ER/PR positive, but others reading this thread may be and should exercise caution with resveratrol
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
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03-28-2009, 10:18 PM
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#7
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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I am ER positive. Thanks for the caution.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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03-29-2009, 08:34 AM
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#8
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Thanks Laurel for the clarification info, I'm triple +.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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03-29-2009, 10:36 AM
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#9
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Senior Member
Join Date: Aug 2007
Location: Newport Beach, CA
Posts: 161
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Good work, Laurel
Glad you posted this, Laurel, as attention to the fine details is crucial. Even though I'm ER-, maybe I'll save my money on this expensive supplement and just drink grape juice or when the organic red grapes come back to the market, buy those. Then, I wash and freeze them and eat them as frozen treats.
Have a grapeful day,
Vic
__________________
Diagnosed 12/03 at age 53
1.5cm tumor, ER-PR-, Her2 3+(rt side)
Stage 1B, Three negative nodes from Sentinel Node Biopsy
Paget's of the nipple, Infiltrating Ductal Carcinoma and DCIS of the rt breast
Bloom-Richardson score 8/9, P53+ 60-70%, Ki-67+ 30-40%
Skin-sparing mastectomy with immediate lat-flap reconstruction and saline implants, 1/04
Chemo: FAC, five sessions every three weeks Feb.-May 04, then switched to HTC weekly for 12 weeks, June-Aug 04
Zometa every 6 months for osteopenia, started April 09
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03-31-2009, 11:28 AM
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#10
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Senior Member
Join Date: Aug 2007
Location: Newport Beach, CA
Posts: 161
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Sent by Biotivia, makers of Resveratrol, read accordingly, for science types, not me
Anticarcinogenicity Studies of Resveratrol
Test System or Species, Strain, and Age, Number, and Sex of Animals Chemical Form and Purity Route, Dose, Duration, and Observation Period Results/Comments Reference In Vitro Assays
Mammary glands of mice, BALB/c, 3- to 4-wk-old,number n.p., F
resveratrol, purity n.p.
incubation with 1, 2.5, 5, and 10 µM (0.2, 0.57, 1, and 2.3 µg/mL) for the first 10 days of 14-day culture (Ductal lesions were induced with 2 µg/mL DMBA on day 3 for 24 h.)
The incidence of hyperplastic and aggressive ductal lesions
induced by DMBA was reduced by resveratrol in a dose dependent manner (IC50 ~3 µM).
Bhat et al. (2001)
Human breast cancer cell
lines: ER-positive KPL-1
and MCF-7 and ERnegative MKL-F
trans-resveratrol,
99.8% pure
incubation with 0.01-40 µg/mL (0.04-180 µM) for 24, 48, 72, and 96 h At ≥44 µM, the growth of all cell lines was inhibited in time- and
dose-dependent manners.
The IC50 for the 72-h treatment ranged from 105 to 149 µM. At lower concentrations of resveratrol,moderate inhibition of the growth of MKL-F and stimulation of
KPL-1 and MCF-7 in a time-dependent manner were seen. At 72 h, the cells were stimulated by up to 132 and 115% of control level, respectively.
Nakagawa et al. (2001)
Human breast cancer cell
lines: hormone-sensitive
MCF-7 and T47-D and
hormone-resistant MDAMB-
231
(+)-resveratrol,
>99% pure
incubation with 10-12 – 10-6 M
(1 pM-1 µM [2 x 10-7 -0.2 µg/mL]) for a total of 6 days;applied on day 2 (one cell cycle) and day 5 (three cell
cycles)
Cell proliferation was inhibited in a dose-dependent manner in all cell lines; the effect after day 5 was more apparent than at day 2. The IC50 and maximum inhibition of resveratrol were as follows:
IC50 (pM) Inhibition
MCF-7 13.7±8.3 0.42
T47-D 0.1±1.2 0.56
MDA-MB-231 5.2±9.1 0.30
Damianaki et al. (2000)
Prostate cancer cell lines:
hormone-sensitive LNCaP,PC3, and DU145
(+)-resveratrol,
>99% pure
incubation with 10-12 – 10-6 M
(1 pM-1 µM [2 x 10-7 -0.2 µg/mL]) given one day after seeding (day 0) and cultured for 6 days
Resveratrol had no effect in LNCaP cells (IC50 = >10-6 M). At >10-7 M, resveratrol produced partial inhibition of growth in the PC3 cell line (IC50 = 0.11±1.23 x 10-6 M; maximum inhibition at 0.48). In DU145 cells, it was a potent inhibitor of cell growth, which was time- and dose-dependent (IC50 = 0.57±0.58 x 10-12 M; maximum inhibition at 0.82). In LNCaP cells, resveratrol was a very weak competitor of androgen binding.
Kampa et al. (2000)
Prostate cancer cell line
LNCaP
resveratrol, purity
n.p.
incubation with up to 200 µM (45.7 µg/mL) for 24 or 32 h with or without Mib 2 days after cells were seeded
At 100 µM, Mib-stimulated cell growth was inhibited and very little apoptosis was observed. At 200 µM, massive apoptotic cell death was seen.
Mitchell et al.
(1999)
In Vivo Assays
Mice, C57B16/J
(implanted s.c. with a
murine T241 fibrosarcoma
in the middle dorsum
[tumors visible after 72 h]), 5- to 6-wk-old, 6-7M/group
resveratrol, >99% pure
oral; 5.7 µg/mL (25 µM) or 1 mg/kg/day in absolute ethanol added to drinking water for 25 days
Resveratrol significantly inhibited the growth of T241
fibrosarcomas in the animals.
Bråkenhielm et al. (2001)
Rats, F344, 2-mo-old,
10M/group
resveratrol, purity
n.p.
oral; 200 µg/kg (0.876 µmol/kg) bw/day in drinking water for 100 days beginning 10 days before s.c. injection of 2 doses of 15 mg/kg AOM 1 wk apart
The number of ACF in the colorectal mucosa (25.7±3.6 vs.
39.4±3.3 in controls) and mean multiplicity (2.7±0.3 vs. 4.9±0.6 in controls) were significantly reduced. Resveratrol also reduced the number of small and medium ACF and stopped the development of large ACF. Compared to controls, bax was significantly expressed in ACF of
treated rats (53±1.3% and 57±1.3%, respectively) but not in the surrounding mucosa. In addition, p21 was expressed in ACF of treated rats but to a lower degree compared to controls (1.5±0.1% and 2.2±0.1%, respectively) but not in the normal mucosa.
Tessitore et al. (2000)
Rats, Sprague-Dawley, 42-days-old, 20F/group
resveratrol, purity n.p.
intragastric; 10 and 100 mg/kg (0.044 and 0.438 mmol/kg) bw 5 days/wk starting 7 days before NMU administration and terminating 120 days after administration of NMU
By day 21, tumors were palpable in the control group after NMU administration. By day 111, 100% incidence was reached. The high dose of resveratrol delayed tumorigenesis: on day 40, 0% incidence was observed versus 42% incidence in the control group; the median time for appearance of the first tumor was 79.5 days in the treated group versus 51.5 days in the control group; at
termination, the multiplicity of tumors was 3.9 versus 6.0 in
control animals. There was also a decrease in the total number of tumors. Morphologically, there was an increase in differentiated alveolar structures among tumor parenchyma, focal reduction of cell layers and numerous luminal openings within alveolar structures, and necrosis and apoptotic cells in small areas of some tumors.
Bhat et al. (2001)
__________________
Diagnosed 12/03 at age 53
1.5cm tumor, ER-PR-, Her2 3+(rt side)
Stage 1B, Three negative nodes from Sentinel Node Biopsy
Paget's of the nipple, Infiltrating Ductal Carcinoma and DCIS of the rt breast
Bloom-Richardson score 8/9, P53+ 60-70%, Ki-67+ 30-40%
Skin-sparing mastectomy with immediate lat-flap reconstruction and saline implants, 1/04
Chemo: FAC, five sessions every three weeks Feb.-May 04, then switched to HTC weekly for 12 weeks, June-Aug 04
Zometa every 6 months for osteopenia, started April 09
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03-31-2009, 07:54 PM
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#11
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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As my doctor used to tell me, "...last time I looked, you were not a mouse..." - whenever I brought mouse model research to him. LOL
I think the reason that my nutritionist steered me clear of the supplement - is because all there is for proof so far is mouse model research, and as I have learned, that doesn't mean it directly corresponds to humans. (though sometimes it does...)
Thanks for the info though...
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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04-19-2009, 10:49 AM
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#12
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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1: Clin Exp Metastasis. 2009 Mar 18. [Epub ahead of print] Links
Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols.
Castillo-Pichardo L, MartÃ*nez-Montemayor MM, MartÃ*nez JE, Wall KM, Cubano LA, Dharmawardhane S.
Department of Biochemistry, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA.
The cancer preventive properties of grape products such as red wine have been attributed to polyphenols enriched in red wine. However, much of the studies on cancer preventive mechanisms of grape polyphenols have been conducted with individual compounds at concentrations too high to be achieved via dietary consumption. We recently reported that combined grape polyphenols at physiologically relevant concentrations are more effective than individual compounds at inhibition of ERalpha(-), ERbeta(+) MDA-MB-231 breast cancer cell proliferation,resveratrol, quercetin, or catechin cell cycle progression, and primary mammary tumor growth (Schlachterman et al., Transl Oncol 1:19-27, 2008). Herein, we show that combined grape polyphenols induce apoptosis and are more effective than individual at inhibition of cell proliferation, cell cycle progression, and cell migration in the highly metastatic ER (-) MDA-MB-435 cell line. The combined effect of dietary grape polyphenols (5 mg/kg each resveratrol, quercetin, and catechin) was tested on progression of mammary tumors in nude mice created from green fluorescent protein-tagged MDA-MB-435 bone metastatic variant. Fluorescence image analysis of primary tumor growth demonstrated a statistically significant decrease in tumor area by dietary grape polyphenols. Molecular analysis of excised tumors demonstrated that reduced mammary tumor growth may be due to upregulation of FOXO1 (forkhead box O1) and NFKBIA (IkappaBalpha), thus activating apoptosis and potentially inhibiting NfkappaB (nuclear factor kappaB) activity. Image analysis of distant organs for metastases demonstrated that grape polyphenols reduced metastasis especially to liver and bone. Overall, these results indicate that combined dietary grape polyphenols are effective at inhibition of mammary tumor growth and site-specific metastasis.
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04-20-2009, 07:04 AM
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#13
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Senior Member
Join Date: Aug 2007
Location: Newport Beach, CA
Posts: 161
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Fascinating, Rich. Thanks!! I'll print this out and take it to my onc. visiti today along with Lani's post on the "IMPORTANT discovery" post on MUC4.
That's what this board is all about. Appreciate everyone's knowledge, curiosity and research capabilities.
Vicki Z
__________________
Diagnosed 12/03 at age 53
1.5cm tumor, ER-PR-, Her2 3+(rt side)
Stage 1B, Three negative nodes from Sentinel Node Biopsy
Paget's of the nipple, Infiltrating Ductal Carcinoma and DCIS of the rt breast
Bloom-Richardson score 8/9, P53+ 60-70%, Ki-67+ 30-40%
Skin-sparing mastectomy with immediate lat-flap reconstruction and saline implants, 1/04
Chemo: FAC, five sessions every three weeks Feb.-May 04, then switched to HTC weekly for 12 weeks, June-Aug 04
Zometa every 6 months for osteopenia, started April 09
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04-20-2009, 08:23 AM
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#14
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Member
Join Date: Mar 2009
Location: Fort McMurray, Alberta
Posts: 13
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here is what my onc nurse sent me when I inquired about resveratrol.
Have a great day!
Love Jan
__________________
Feb. 3 /09 routine Mammogram,
Feb 27/09 Mastectomy, left breast
23/26 lymph nodes positive yikes!!
Her 2 positive
stage 4 metastatic (bones,lung and multiple regional & non regional lymph nodes)
Started New Trial NCIC MA.31 April 8/09
Docetaxel every 3 weeks + 5 Lapatinib daily ...so far so good...:)
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04-21-2009, 04:28 PM
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#15
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Senior Member
Join Date: Aug 2007
Location: Newport Beach, CA
Posts: 161
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Here's what my onc. said about Resveratrol
After I saw my oncologist yesterday, she said she would speak with one of her colleagues who has been doing some studies on Resveratrol and here is what she wrote me in her email today:
"he told me he tells breast cancer patients to avoid Resveratrol because of data showing that it can stimulate some breast cancer cell types."
So, there you have it. That's one opinion, but it seems to go along with what others have also posted.
Vicki Z
__________________
Diagnosed 12/03 at age 53
1.5cm tumor, ER-PR-, Her2 3+(rt side)
Stage 1B, Three negative nodes from Sentinel Node Biopsy
Paget's of the nipple, Infiltrating Ductal Carcinoma and DCIS of the rt breast
Bloom-Richardson score 8/9, P53+ 60-70%, Ki-67+ 30-40%
Skin-sparing mastectomy with immediate lat-flap reconstruction and saline implants, 1/04
Chemo: FAC, five sessions every three weeks Feb.-May 04, then switched to HTC weekly for 12 weeks, June-Aug 04
Zometa every 6 months for osteopenia, started April 09
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