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Old 12-21-2010, 02:55 PM   #1
StephN
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Wink New HER2 vaccine trial to watch for

Mayo Clinic
Cancer
TapImmune Inc. has signed an exclusive Licensing Option agreement with Mayo Clinic, Rochester, MN, for clinical development of a breast cancer vaccine technology. The option to license this technology can be exercised after Phase I clinical trials under terms agreed between Mayo Clinic and TapImmune. Mayo Clinic will conduct a Phase I clinical trial in breast cancer patients who have a form of breast cancer that express Her2/neu receptors (also called Her2/neu breast cancer). Keith Knutson, M.D. will serve as Principal Investigator.
Her2/neu receptor related cancer is a very aggressive form of breast cancer that affects a subset of breast cancer patients. It is a well established therapeutic target, which helps our development goals from a regulatory standpoint. For example, Herceptin (a Her2/neu inhibitor by Genentech) is an approved drug with annual sales in excess of $4 Billion. </STRONG>
There are ongoing vaccine trials targeting Her2/neu. The major disadvantage (as we understand) of technologies that are currently in development are their inability to cover all or a majority of Her2/neu cancer patients and their ability for long-term protection. Some of them seem to be effective only in a subset of Her2/neu cancer patients due to the nature of the peptide epitopes used. Along with Mayo we believe this technology is could cover up to 90% of the Her2/neu patients and last a very long time (if not a life time), which is an improvement that could cover an additional 30% of the population who may not be covered by the other technologies that are currently in development. </STRONG>
Dr Glynn Wilson, Executive Chairman of TapImmune, stated, “The option to license this technology from Mayo Clinic represents a significant opportunity to add to our cancer vaccine portfolio and clinical research programs. We believe that this technology offers a number of advantages in the development of a breast cancer vaccine for a broad patient population
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"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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Old 12-21-2010, 08:49 PM   #2
ElaineM
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Wink Re: New HER2 vaccine trial to watch for

Thanks for sharing the news about another upcoming her2 option.
We need alot of ammunition to fight her2 breast cancer.
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Old 12-24-2010, 04:06 AM   #3
Ellie F
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Re: New HER2 vaccine trial to watch for

Thanks Steph
Life long immunity! Wow that would be a quantum leap for her 2 breast cancer.
Ellie
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Old 01-03-2011, 01:32 AM   #4
Jackie07
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Re: New HER2 vaccine trial to watch for

Thanks, Steph.
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe
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Old 01-03-2011, 09:54 AM   #5
'lizbeth
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Re: New HER2 vaccine trial to watch for

Yeah, another cancer vaccine!
However, ladies, there are current trials that you may be able to participate in with the peptide vaccines. If you are less than 6 months from the end of Herceptin you can still enroll, and get the benefit of a vaccine, and help move science along for the rest of us!

I am so grateful to all of you who participated in a clinical trial. I had my nose in every medical journal I could find when I first was diagnosed.
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Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"

Additional treatments:
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Old 03-09-2011, 10:37 AM   #6
feonad
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Re: New HER2 vaccine trial to watch for

Is this for stage 4 breast cancer?
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Old 03-28-2011, 06:35 PM   #7
Cure4Cat
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Re: New HER2 vaccine trial to watch for

Thank you Steph!! I am new to this site and this is my first post. I want to thank you and Lani and all the others for your research skills! I am a young Mom who was diagnosed Jul 2010, with stage 2b her2+, ER+, PR- breast cancer. My son was 6 months old. I am currently in a clinical trial for pertuzumab but I have been looking for a vaccine trial for when I finish Herceptin.
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Old 03-28-2011, 07:43 PM   #8
Jackie07
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Re: New HER2 vaccine trial to watch for

Cat (?),

You probably already known this website:

http://www.clinicaltrials.gov/

Other threads of Clinical Trials discussion/listing can be located either by using the 'Search' box, or by clicking on the Hot Link of 'Clinical Trials'.

There are quite a few 'young' women on the Board. One of them (Laurie=Laureen)had given birth to a boy a couple of years after she had completed her treatment and will have another girl delivered in June. She stops by every once in a while, and I hope you all can get connected soon.

I think you can also find the Conference schedule of the Young Women's Coalition somewhere.

Good luck to your treatment. Be sure to arrange for help for both you and your baby. (Check with your local American Cancer Society chapter. Also check and see if there's a chapter of 'cleaning for a reason' http://www.cleaningforareason.org/ in your area.
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe

Last edited by Jackie07; 03-28-2011 at 09:23 PM..
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Old 03-28-2011, 07:59 PM   #9
Cure4Cat
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Re: New HER2 vaccine trial to watch for

Thank you Jackie07! I have checked the trials link but so far they are only for later stage Her2. I will keep checking though. Thank you for all the great advice! I live in Ottawa, Canada. I have contacted the Canadian Cancer Society and they have some programs. My parents have been a big help. I also have a wonderful husband. I will try and find Lauren. I hope to attend the next Young Survivor Conference. I should mention, I am willing to participate in US trials. You guys seem to get them before we do in Canada. All the best to you.

Cat
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Dx Her2+, ER+, PR-, stage 2b/3 July 2010
Chemo Sept-Dec 2010
(Pertuzumab during last 3 rounds of chemo)
Surgery Jan 2011
25 Rads March 2011
Herceptin started during chemo and continued every 3 weeks for 1 year
Started Tamoxifen for 5 years

Looking for a vaccine trial
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Old 03-28-2011, 08:40 PM   #10
Jackie07
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Re: New HER2 vaccine trial to watch for

Here's a site where you can input your information to find a match:

https://www.breastcancertrials.org/bct_nation/home.seam

After you enter your information, it will also notify you when a new clinical trial matches your profile if you choose to have such option.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe
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