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Old 03-05-2008, 09:38 PM   #1
lilyecuadorian
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Join Date: Mar 2007
Location: CHARLOTTE NC USA Home town (ECUADOR) South America
Posts: 542
Post Do anybody know about this clinical trial ?

I have this prosedure done to my brain with NOVALIS ...but I find this and I just want to share ...any thoughts ????
http://radonc.urmc.rochester.edu/nov...vinCenter.html
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Lily
Diag April/06 5 months after give birth my son Max
stage IV mets on liver (5 tumors) 38 year old,
her2+++ and ER+PR+ from32 nodes 4 positives
mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen
NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery
5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression
03-05-08 start tykerb & xeloda

Last edited by lilyecuadorian; 03-06-2008 at 06:42 AM.. Reason: misspelling
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Old 03-06-2008, 10:32 AM   #2
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
Lily, I have not heard about this trial but I find it very exciting and encouraging that somebody is actually doing a trial on this as the biggest hurdle is "there is no data". Hopefully this will add more information and this will turn out to be a good option for many more people.

How'd you find this?
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 03-06-2008, 12:18 PM   #3
Lani
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Join Date: Mar 2006
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Thumbs up Welcome trial!

There was an editorial by MD Anderson oncologist musing whether the dire prediction of survival held equally for those who were oligometastatic ie, having only one or few mets and particularly if only one or a few in certain organs ie, bone vs liver vs lungs.
The only way to tell whether close follow-up with scans to catch things early will make a difference is NOT TO TREAT EVERYONE EQUALLY and not scan anyone waiting for symptoms or fractures or the like, is to try to divide breast cancer patients into subgroups and see if finding things early and treating them in various ways (like this NOVALIS treatment) will make a difference.

I have posted papers regarding surgery and radiofrequency ablation seeming to make a difference in survival, but most of these studies are by their nature done with only a few patients.

Let's hope studies like these get taken up internationally--funding may be difficult to find...but the payoff in giving just the right patients just the right treatment and no more and no less will save lives, quality of lives, and costs
of treating patients with so many metastases which are so resistant to so many treatments that the treatments are so much less likely to make a difference and the complications so much worse.

Off my soapbox!
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