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Old 01-28-2008, 12:01 PM   #1
runtolive
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Trastuzumab-dm1

http://www.oncology-times.com/pt/pt-core/template-journal/oncotimes/media/Carlson-CFS-Trastuzumab-OT-Jan102008.pdf

article by dr burris .. just scroll down.. about tras-dm1..

he is running the current once a week tras-dm1 trial in nashville, tn

run to live..
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Old 01-28-2008, 12:02 PM   #2
runtolive
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current phase 1 sites.
The phase I study for trastuzumab-DM1is located at the following institutions:
  • <LI class=MsoNormal style="COLOR: navy; mso-list: l1 level1 lfo3">Dr. Howard Burris at Sarah Cannon Research Cancer Institute, Nashville. E-mail: hburris@tnonc.com <LI class=MsoNormal style="COLOR: navy; mso-list: l1 level1 lfo3">Dr. Monica Mita at Institute for Drug Development, San Antonio. E-mail: mmita@idd.org <LI class=MsoNormal style="COLOR: navy; mso-list: l1 level1 lfo3">Dr. Ian Krop at Dana Farber Cancer Institute, Boston. E-mail: ikrop@partners.org
  • Dr. Shanu Modi at Memorial Sloan-Kettering Cancer Center. E-mail: modis@mskcc.org
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Old 01-28-2008, 12:09 PM   #3
runtolive
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dr burris article on tratuzumab dm1

http://www.oncology-times.com/pt/pt-...-Jan102008.pdf
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Old 01-28-2008, 06:10 PM   #4
lilyecuadorian
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Location: CHARLOTTE NC USA Home town (ECUADOR) South America
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thanks good information Run to live !!!
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Lily
Diag April/06 5 months after give birth my son Max
stage IV mets on liver (5 tumors) 38 year old,
her2+++ and ER+PR+ from32 nodes 4 positives
mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen
NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery
5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression
03-05-08 start tykerb & xeloda
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Old 02-03-2008, 09:53 PM   #5
chrisy
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Great article

But I have to admit, run to live, that when I see your screen name my first thought is of the smallest olive in the litter...guess it's just a twisted cognitive misperception!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 02-04-2008, 09:33 AM   #6
runtolive
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actually my olives are quite nice..
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