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Old 01-31-2008, 06:23 AM   #1
eric
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Pertuzumab (Omnitarg™) and Herceptin® (Trastuzumab)
http://professional.cancerconsultant....aspx?id=41280


Pertuzumab (Omnitarg™) and Herceptin® (Trastuzumab) Effective for Metastatic HER2-Positive Breast Cancer
Researchers involved in an international study have reported that the combination of Omnitarg and Herceptin has significant activity in women with HER2-positive breast cancer who progressed on Herceptin alone. The details of this Phase II study were presented at the 2007 meeting of the San Antonio Breast Cancer Symposium (SABCS) in December.1
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Old 02-03-2008, 09:48 PM   #2
chrisy
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Eric,
I saw this presentation at San Antonio, and if you go to the sabcs.org website, click on "highlighted presentations and view Dr. Kent Osborne's mini symposium from Dec 16. It is a very thorough (and understandable) review of Her-targeted therapy and mechanisms of resistance. The key is to go for a complete blockade of the entire Her family - and the pertuzumab/herceptin trial is a step in the right direction. He also notes the next step will be to add another agent to close off another path. Very exciting stuff.
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 02-04-2008, 06:12 AM   #3
eric
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Chrisy,

I agree on both accounts. I found Dr Osborne's presentation extremely informative and easy to understand and I do find this to be very exciting for all of us.
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Old 02-15-2008, 05:58 PM   #4
Kim in DC
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I have agreed to participate in this trial. I currently have mets to the sternum and some soft tissue mets in my reconstructed breasts. After I complete rads and go through all the tests, I will start. I will definitely be getting herceptin and taxotere, I don't know if I will have placebo or not. The onc nurses at my office say they are getting the actual drug because they can tell by the way it bubbles in the bag. I promise to keep you informed.

Kim
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8/98 dx right breast
5/2003 tram flap right breast
8/2004 dx new primary left breast with inflammatory bc
er/pr-, her2neu+++
8/19 taxotere and herceptin
1/15/2005 Navelbine/Herceptin
4/2005 radiation and Herceptin
5/15/2005 Herceptin alone
2/12/2008 skin biopsy positive
2/14/2008 met to sternum, possibly right breast
2/27/08 Start omitarg, herceptin, taxotere trial
3/17/08 Kicked off trial because I started too close to my last herceptin
3/19 start tykerb xeloda
Right breast confirmed met
5/15/08 skin mets gone, no hypermetabolic activity in breast, sternum healing
8/24/08 scans still look good. sternum still active with scarring. No evidence of progression
10/08 Progression in sternum
12/08 Start TDM1 trial
1/09 Scans show stable
12/09 1 year on TDM1 still stable
10/10 progression in chest and liver
11/10 false positive of liver mets; tykerb and herceptin
4/11 Tykerb/Herceptin/Xgeva
4/11 Rads to Sternum
5/12/12 NED Herceptin/Zometa
3/16/19 still NED Herceptin/Zometa very 6months
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Old 02-16-2008, 01:55 PM   #5
StephN
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Dear Kim -
SO sorry to hear of the progression. You seemed to be doing well, but we all know this disease is a very sneaky devil.

You are another brave trailblazer in the search for more effective treatments for our kind of mets.

All my positive thoughts that you WILL get the new drug in your combo. Keep us posted on how things go after the radiation.
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"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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