Herceptin or Tykerb ?

[alex1]

Onco suggested Navelbine + Gemcitabine . As per onco disease not responding to aggressive traetment being given .What are other options at this stage ?


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Age 38 years
17 Feb 2010 – Mammography – Mass in right breast suspicious of malignancy
19 Feb 2010 – FNA from right breast – Duct carcinoma cells seen
04 Mar 2010 – Right radical modified mastectomy – tumor 3X3X2, LN1/19 +ve
15 Mar 2010 – Hormone receptor – ER negative, PR negative, c erb B2 –
positive score3
25 Mar 2010 – Detection of HER-2/neu by FISH - positive
1 Apr 2010 – Chemotherapy Started – 3 CEF + 4 Docetaxel + Herceptin (3wkly X 17)
30 May 2011 – Course of Herceptin completed
9 Aug 2011 – CT Scan – focal lesion 3.2X2.9cm in segment IV of liver
10 Aug 2011 – PET-CT Scan – solitary hepatic metastasis, precaval LN
suspicious mets
15 Aug 2011 – Oral chemotherapy started – Tykerb 250, Xeloda 500
28 Feb 2012 – PET-CT Scan –hepatic metastasis,lymphatic
metastasis,skeletal metastasis
03 Mar 2012 - I.V. 3 weekly chemo started PacliALL (Paclitaxel ) given
05 May 2012 - PET CT Scan " Hypermetabolic hepatic , lymphatic and osseous metastates . Paclitaxel ineffective.