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Old 04-21-2012, 05:32 PM   #1
DeenaH
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Retesting ER status

I am going to have my most recent tumor (from my lung) retested for ER status. I have heard that false negative results are as high as 20%. There is new technology that tests for ER status with quantitative accuracy. This is call AQUA technology, and the testing can be done with 5 unstained slides of tumor or 1 tumor block. The best part is that Genoptix who does that testing has a "patient first" policy so that the patient never pays out of pocket more than their "in netowork" copay/coinsurance for the test.

I plan to get the ball rolling for mine next week.

Below is a link about the testing. I just thought I would share. I know it is a long shot, but imagine if those of us who tested ER- were to all of a sudden be able to use drugs like Tomoxifin or AI's??

http://www.genoptix.com/nexcourse_bca.html
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March 2010: Diagnosed with Stage IIIC IDC with axillary, mammary and suplaclavicular node involvement. ER/PR -, HER2+++. 7cm tumor in right breast.
April 2010: Started neoadjuvent chemo. 4 DD A/C every 2 weeks, 4 DD Taxotere every 3 weeks with Herceptin weekly.
August 2010: Finished chemo!
August 20, 2010: PET/CT showed no cancer in any nodes, and only a little uptake to the breast.
September 9, 2010: Bilateral mastectomy with immediate reconstruction with implants and Alloderm.
September 16, 2010: Pathology report showed 18/51 positive axillary nodes, 3.2cm tumor. Granual sized cancer found in the fatty tissue between levels 1 and 2.
October 19, 2010: CT showed several spots on lungs and 1 spot on liver. Liver spot is 2mm, lung spots range from 2mm to 4mm. We don't know if they are cancer or not.
12/15/10: Brain MRI clear
1/7/11: PET/CT
1/13/11: Recurrence in lungs. Start Tykerb
5/13/11: Progression in lungs
6/3/11: Lung surgery to get tumors for chemosensitivity testing.
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Old 04-21-2012, 09:11 PM   #2
Jackie07
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Re: Retesting ER status

Good for you.

I do remember reading about one member's report that her met sample was showing a different feature from the original biopsy.
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Old 04-22-2012, 09:38 PM   #3
Rich66
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Re: Retesting ER status

Quote:
imagine if those of us who tested ER- were to all of a sudden be able to use drugs like Tomoxifin or AI's??
Seems worth the investigation. good to know there are increasing options in testing for ER. In addition to varying results within a given tumor, there is the ongoing and disturbing issue of delayed fixation to slides influencing said results..but ya do what ya can.
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