 |
11-07-2010, 09:08 PM
|
#1
|
|
Member
Join Date: Oct 2010
Posts: 7
|
TCH or FEC?
We have our first oncologist consultation tomorrow so I've been studying what I can tonight, based on my wife's diagnosis I'm assuming her oncologist will recommend either TCH or FEC (plus herceptin), but I haven't been able to find anything that would indicate why one or the other. Any assistance is appreciated.
Thank you.
__________________
on behalf of my wife. DOB: 11/1960
Diagnosed IDC on 7/27/10 in right breast (plus 3 areas of DCIS)
ER-/PR-/HER2+++
1.6 CM tumor size, 1/4 nodes positive
CAT/MRI/Bone all negative for mets (august 2010)
Unilateral mastectomy/immediate DIEP reconstruction on 10/15/10
Started 6 rounds of TCH on 12/9/10, continuing with herceptin for a year
|
|
|
|
11-08-2010, 07:56 PM
|
#2
|
|
Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
|
Re: TCH or FEC?
Matthew,
If you google ACTH (adriamycin, cytoxin, taxol, herceptin) vs TCH (taxol, carboplatin, herceptin) you will find a good bit of information. The long term studies are not in yet, but the stats thus far look fairly equal. FEC is similar to ACTH with the Epirubicin being a less cardiotoxic version of Adriamycin and the Cytoxin is the same. I do not know much about 5FU as it is not used for breast cancer much here in the States. I do know that it is not advisable for the Eprirubicin to be administered in conjunction with the Herceptin, sequentially is the way to go with Herceptin being given upon the completion of the Eprirubicin.
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
|
|
|
|
|
11-08-2010, 08:48 PM
|
#3
|
|
Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
|
Re: TCH or FEC?
Matthew,
I was given FEC x 3, then Taxotere x 3, then I had my Herceptin, every 3 weeks for a year. My onc. strongly recommended the Taxotere along with the FEC, said it was very good fighting Her2+ BC.
FEC is commonly used in Canada, England and other commonwealth countries.
TCH is a newer combo, I don't know if it is given in Canada yet, as I am over 3 years post chemo, and over 2 years post Herceptin.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
|
|
|
|
|
11-08-2010, 10:16 PM
|
#4
|
|
Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
|
Re: TCH or FEC?
Hi,
I had FEC for my first diagnosis in 2003. I think FEC was used in place of AC because of my lower than normal heart function. When TCH became the standard, I had TCH in 2007 for the local regional recurrence.
Since Herceptin is 'the' cure for Her2 breast cancer, I think TCH should be the choice for your wife. There are studies showing each drug targets certain part of the cancer cell (skeleton, etc.) Maybe that's why the newer protocol uses both. If you look at other newly diagnosed, seems several of them are doing 4 AC (=FEC) and then TH, then Herceptin only.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
Last edited by Jackie07; 11-08-2010 at 10:20 PM..
|
|
|
|
|
11-08-2010, 10:55 PM
|
#5
|
|
Guest
|
Re: TCH or FEC?
Ghosts, christmas tree pumpkins, luxury bags angels, vibram fivefingers demons, christmas tree vampires, christmas lights witches, burberry sale bats, Christian Audigier werewolves, Damenstiefel butterfly, ugg boots cat demon, угги Bunny, Superman, cheap nike shox doctors, police, pirate cheap ugg boots ... ... just Santa Claus the uggs online names ugg boots on sale to ugg boots sale be damen stiefel composed sheepskin boots of ugg boots numerous artificial christmas trees large, that christmas ornaments is, these cheap ugg boots names coach outlet it snow boots is christmas tree destined damen stiefel to chaussures femmes this schuhe online kind uggs of thriller Ugg Australia is sheepskin boots certainly luggage online large, christmas tree decorations science fiction, ugg boots some uggs of ed hardy them coach handbags are X-rated movie, not mens cufflinks necessarily coach purses the ugg boots domestic snow boots release, christmas tree outlet store not bape suitable угги for children uggs sale to cheap uggs seeGhosts, mbt pumpkins, new balance outlet angels, demons, ugg outlet vampires, ugg boots witches, bats, Ugg Stiefel werewolves, cufflinks butterfly, cat balenciaga handbags demon, new balance shoes Bunny, winter boots Superman, plush toys doctors, police, pirate ugg australia ... ugg boots ... christmas tree just vibram the artificial christmas trees names snow boots to be cheap christmas trees composed balenciaga bags of ugg boots numerous large, discount snow boots that discount ugg boots is, nike shox these christmas strees sale names uggs outlet it is destined Ugg Boots to Ugg Schuhe this kind Ugg Australia of christmas tree thriller is Ugg Schuhe certainly Ugg boots large, iPhone cases science cheap uggs fiction, Ugg Stiefel some uggs of xmas tree them nike basketball shoes are christmas tree X-rated ugg boots australia movie, iPhone accessories not ugg winter boots necessarily ugg boots the nici domestic new balance release, uggs on sale not winter boots suitable for stiefel leder children uggs sale to winter boots seeGhosts, pumpkins, cheap uggs angels, burberry online demons, vibram five fingers vampires, witches, Ugg Boots bats, winter boots werewolves, luggage bags butterfly, ugg australia cat ugg boots demon, Bunny, uggs outlet Superman, five finger shoes doctors, police, artificial Xmas trees pirate burberry outlet ... ... nike dunk just Ugg Boots the names to cufflinks uk be ugg boots australia composed of bathing ape numerous large, Ugg Australia that basketball shoes outlet is, xmas tree these christmas lights names chaussures femmes it uggs on sale is mbt shoes destined uggs online to Ugg Boots this kind of thriller schuhe online is ugg boots certainly large, science ugg boots sale fiction, ugg boots some xmas tree of them nike air force 1 are ugg boots sale X-rated ugg boots movie, luggage not vibram five fingers necessarily the nike sb shoes domestic coach usa release, christmas ornaments not ugg australia suitable ugg outlet for cufflinks for men children Nike air force to snow boots see |
|
|
|
|
11-09-2010, 03:34 AM
|
#6
|
|
Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
|
Re: TCH or FEC?
What seems to be used most often...or known as the standard of care is "ACTH" as Laurel mentioned, & TCH. If you have heard of Dr. Slamon out at UCLA...he is the one that made Herceptin. His clinic will only treat you with TCH. The studies between ACTH and TCH showed very little difference. The main difference is lower risk of heart damage with TCH. So I'm pretty sure your wife will be offered one of those two choices. (It's so nice of you to research online and help your wife out...she is so blessed to have a wonderful husband to support her through this.) You both take care and keep us updated. We are here for you.
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
|
|
|
|
|
11-09-2010, 07:31 AM
|
#7
|
|
Member
Join Date: Oct 2010
Posts: 7
|
Re: TCH or FEC?
thanks to everyone for the information. Our oncologist has recommended 6 courses of Taxotere / Carboplatin, and a year of Herceptin every three weeks. She will receive a port next week and start treatment the week after that. From everything I've read that seems like a pretty common course of treatment for her diagnosis.
__________________
on behalf of my wife. DOB: 11/1960
Diagnosed IDC on 7/27/10 in right breast (plus 3 areas of DCIS)
ER-/PR-/HER2+++
1.6 CM tumor size, 1/4 nodes positive
CAT/MRI/Bone all negative for mets (august 2010)
Unilateral mastectomy/immediate DIEP reconstruction on 10/15/10
Started 6 rounds of TCH on 12/9/10, continuing with herceptin for a year
|
|
|
|
|
11-09-2010, 05:59 PM
|
#8
|
|
Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
|
Re: TCH or FEC?
All the very best, Matthew. Stay in touch and let us know how you two are doing.
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
|
|
|
|
Posting Rules
|
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
HTML code is Off
|
|
|
All times are GMT -7. The time now is 11:01 AM.
|
Linear Mode
