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06-24-2009, 06:17 PM
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#1
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Herceptin vs Tykerb...or alliance.
Ok...if Tykerb is used when Herceptin "fails", has added her3 component..and is thought to cross the blood brain barrier (unlike Herceptin) to protect from brain mets and both are considered cancer stem cell weapons...
Is anyone pushing for Tykerb before or in combination with Herceptin from the get go?
I know there is the inherent chronology of drug development, trials and practice. But...imagine they popped onto the scene at the same time and you could choose one, the other or both.
I'm thinking out loud here that either the combo or Tykerb to start makes more sense.
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06-24-2009, 06:58 PM
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#2
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Senior Member
Join Date: Jan 2009
Location: Colorado Springs, CO
Posts: 430
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I have been wondering that myself. I suspect this will take the route that Herceptin did in getting approved. First for advanced, then for early BC with pos. nodes, and then for those with neg. nodes. Kind of makes me wish they would try it out on every case at the same time. Is this drug in short supply like Herceptin was at the start?
__________________
9/15/08 (age 52) - Mammo: calcifications
9/22/08 - Biopsy: DCIS, grade 3. ER,PR status: Pos. in 75-90% of tumor cells.
10/01/08 - Ob/Gyn appt.: found complex, mostly cystic mass on right ovary - 11cmx12cmx 8cm
10/15/08 - Hysterectomy & Oophorectomy, Lumpectomy: Cyst on uterus, not ovary - all was benign. Breast - 5 of 6 bad margins. 2 Sentinel Lymph nodes removed, both negative. Stage 0, Tis, N0
12/11/08 - Mastectomy & DIEP reconstruction: Surprise! 2 cm Invasive DC, grade 2 found. One benign internal mammary lymph node. Stage 1, T1c, N0, all clean margins. ER+ (Proportion Score = 2/5, Intensity Score = 2/3) and PR+(Proportion Score = 3/5, Intensity Score = 2/3)
HER2 score = 3+
1/09/09 - Oncotype DX: Recurrence S/core of 60 !?!?! ER status is NEG!! PR staus is NEG! HER2 score = 12.2 (still positive, greater than 11.5 is positive).
1/20/09 - Started chemo: TCH
5/26/09 - FINISHED CHEMO!
1/05/10 - FINISHED HERCEPTIN!
1/22/10 - Port-a-catheter removed!
3/07/18 - Still NED
9/10/23 - Still NED
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06-24-2009, 07:12 PM
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#3
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Webmaster
Join Date: Feb 2005
Location: Home of the "Flying Tomato"
Carlsbad, CA
Posts: 2,036
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There is a trial, I think it is called Allto to use Tykerb in the adjuvant setting.
Also, any oncologist can prescribe Herceptin and Tykerb together.
Regards
Joe
__________________
A Proud webmaster to the internet's most informed, educated, COMPASSIONATE and caring group of breast cancer survivors.
Illegitimi non carborundum
My Album
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06-24-2009, 07:21 PM
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#4
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Senior Member
Join Date: Dec 2008
Location: Southern Indiana
Posts: 455
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I ask at MDAnderson if I could be given Tykerb, being stage IV, to prevent mets for going to the brain. They said it wasn't being used for this at this time.
With the threat of the US going to government run health care I may be lucky to continue on Herceptin. The US may be heading to the ways of England. If so... it may get even harder to get Tykerb.
__________________
Alice
04/08 age 50 III IBC Her2+++ ER/PR-8cm 14/14 Double M, Body and Brain CT/PET clear, ? on spine,Muga 53
06/08, 4 A/C, Neulasta
08/08, Herceptin/tax 12 every week
10/08, CT/PET clear, ? on pelvis, hips, MUGA 43, started Enalaprial for heart, Herceptin every 3 weeks
11/08 33Rads; 12/08 MUGA 48
2/09 MRI spine and bone scan, old mets to spine, Chest x-ray, blood work, IV NED,regular CPAP use,Zometa x6, first -flue like symptoms 2 days;Herceptin x3; stage 2 lymphoedema..sleeve and glove
4/09 Brain MRI - CLEAR; MUGA 54
7/09 chest ultrasound,
10/09 PET, brain and spin MRI NED Herceptin only. MUGA 59!!!
1/11 Hip replacement 7/11 Hip 2 replacement
4/12 4 years!! Herceptin
6/12 start reconstruction finish in 12/12
2/14 Herception - 6 years!!!
1 Corinthians 10:13 "No temptation has seized you except what is common to man. And God is faithful; he will not let you be tempted beyond what you can bear. But when you are tempted, he will also provide a way out so that you
can stand up under it."
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06-25-2009, 08:24 PM
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#5
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Member
Join Date: Jun 2009
Posts: 20
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Try Breastcancer.org and search for "herceptin and tykerb synergism". Seems the combination is best.
Rob
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06-26-2009, 04:15 PM
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#6
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Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
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There are a few studies with Tykerb in the adjuvant setting for early Her2 + BC, but all the ones I looked at required a tumor size of 1cm or greater.
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
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06-27-2009, 07:29 PM
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#7
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Senior Member
Join Date: May 2009
Posts: 510
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I'm on a clinical trial at Stanford where I'm getting Tykerb before Herceptin. I started with 4 cycles of dose-dense AC (every two weeks), followed by 4 cycles of Taxotere at every three weeks with daily Tykerb (1250mg or 5 pills).
I'll have my last Taxotere in a couple of weeks and I'll take my first dose of Herceptin the same (next?) day I finish my last Tykerb pills. Then it's off to surgery. I'll be on Herceptin for a year.
I was glad to have found the trial at Stanford and to know that I'm getting a good combo of drugs from the get-go. I hope it works and more women will have access to it in the near future.
For those interested, here's a link to the trial:
http://med.stanford.edu/clinicaltria...d=136&age=adul
__________________
ER+ (30%)/PR-/HER-2+, stage 3
Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin
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07-02-2009, 02:09 PM
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#8
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Oh...forgot to mention the cardiac issue with Herceptin.
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06-22-2010, 10:52 AM
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#9
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Senior Member
Join Date: May 2010
Location: New Roads, LA
Posts: 35
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Re: Herceptin vs Tykerb...or alliance.
The ALLTO study is to hopefully have Tykerb approved as a first line drug, just as Herceptin is now. They are hoping that it will be a better drug at preventing brain mets, since it is a smaller molecule that works from inside the cell. I was randomized into the group that would only get Tykerb and chemo, so I backed out. My kids were uneasy about me not getting the Herceptin. Now I am having second thoughts....this is driving me crazy!!! I would like to get both drugs.
__________________
Toni
Found lump...Oh, crap!
Dx 4/29/10
Invasive Poorly Differentiated Ductal Carcinoma. BRCA 1&2 no mutations(although 2 cousins also are HER2+)HMMM....
Stage IIB, G3
ER/PR -, HER2+++
5/11/10 Lumpectomy/Axillary node dissection/Mediport placement
Tumor 3.5cm, 1/15 nodes + Both Sentinel nodes negative!
6/24/10 - Started TCH.
10/14/10 - Finished chemo...yea!!!!!
12/27/10 - PET scan and MRI-NED!!!!!
03/09/11 - Bilateral Mastectomy and reconstruction (DIEP Flap)
03/16/11 - NED! Path report negative!
6/9/11 - Revision of both breasts, and port removed. Two lumps removed...both benign!
6/23/09 - LAST HERCEPTIN!!! Wohooooo!
My son Tim and his wife Nicole just had their first born...a son, Brayden...my first Grandchild! My daughter Hanna is working her way through college, and I am so proud! God has blessed me.
Update...as of 10/2013...still NED, and my son and daughter-in-law just had identical twin girls!!! They have blessed me with 3 beautiful grandchildren in 27 months!! Haha!
My beautiful daughter, Hanna, is still working toward her degree and working full-time.
God is so good:)
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