Lani,
I really appreciate the time and effort you put into finding and posting these studies. I don't have a science background, but I do try to understand what's being reported. If only they would report these things as debits and credits, i'd have it licked!
I interpreted this as follows:
They used data from 82 cases to compile the "best 30 list" of predictive factors. These were used to predict whether a patient would have a complete response to T/FAC chemotherapy or would have residual disease after this chemo?
The results showed that this 30 factor list analysis was highly accurate in predicting complete response or residual disease and more accurate than "other clinical factors" including age, grade and ER status was in predicting complete response and residual disease, (but residual disease prediction difference was not statistically significant).
The conclusion is that this "test" is a better predictor of response to this particular chemo, and if used, could spare people doing this chemo and having it not work(or steer them to other chemos).
Am I close?
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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