for RB and others interested in N6/N3 PUFAs and the lipidome

[Lani]

Prostaglandins Leukot Essent Fatty Acids. 2008 Oct 17. [Epub ahead of print]

The lipidome as a composite biomarker of the modifiable part of the risk of breast cancer.

Bougnoux P, Hajjaji N, Couet C.
INSERM U921 Nutrition, Croissance et Cancer, HS Kaplan Cancer Center - CHU Bretonneau, 2 bis Boulevard Tonnellé, 37044 Tours, France.
The potential for dietary fat to prevent breast cancer makes identification of defined molecules a mandatory step. In order to circumvent the limitations and/or bias of dietary exposure assessment tools, we have used the fatty acid composition of white adipose tissue as biomarker of past lipid intake. When considered separately, candidate fatty acids identified as favourable on the basis of their association with breast cancer risk have usually led to inconsistent results in dietary intervention studies carried out in rats. This inconsistency indicates that any approach based on a single fatty acid should be abandoned for an integrated view over the complex lipid interactions, which finally determines the lipidome, the lipid profile that is found in individuals. We reappraised the role of the complete lipid profile through a comprehensive study of adipose tissue fatty acids obtained in patients with benign or malignant breast tumors. Rather than a single fatty acid, a composite indicator combining elevated monounsaturates and low n-6/n-3 fatty acid ratio was associated with decreased breast cancer risk. The lipidome may provide the opportunity to quantify the modifiable part of the risk of breast cancer. The lipidome may be used as a template for designing proper dietary modifications in order to delay the occurrence of breast cancer. Which dietary modifications should be undertaken in order to bring a pertinent change to the lipidome with respect to the risk of breast cancer is currently unknown. The lipidome may allow the individualization of a high risk population of women, who may be targeted for a dietary prevention of breast cancer. The setting and validation of a high-throughput lipidomic station with analytical capabilities fitted to the need of mass screening is required. These two locks must be resolved before a primary prevention of breast cancer by diet could be contemplated.
PMID: 18930643 [PubMed - as supplied by publisher]

[R.B.]

"In order to circumvent the limitations and/or bias of dietary exposure assessment tools, we have used the fatty acid composition of white adipose tissue as biomarker of past lipid intake."

"The setting and validation of a high-throughput lipidomic station with analytical capabilities fitted to the need of mass screening is required. These two locks must be resolved before a primary prevention of breast cancer by diet could be contemplated."


IF ONLY !!!!!!!

SO BASIC AND YET OF FUNDAMENTAL IMPORTANCE TO HUMAN HEALTH AND SEEING A LARGE PART AS TO WHY ALL WESTERN CONDITIONS ARE RISING

Translated.

Fat is an accurate record of your long term dietary fat intake. (blood is shorter term and questionnaires can be way out - that odd treat you forgot to mention etc)

They need funds (No body except maybe the health insurers has any commercial interest in making you better if there is not a drug or treatment process at the end of it so commercial funding for things like this is hard to come by)