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Re: TDM-1 results reported @ ASCO annual mtg 2012 now in New England Journal of Medic
5-7years is a long time but I can understand their reasoning. We need to come up with a way to determine what is the best treatment for each person. There are people for whom TDM1 has had no benefit - it may, in the early BC setting be no better than the current treatments - the only way to test that is to do trials. I know of many girls who did the TYkerb instead of Herceptin trial in EBC only to recur (and the results did show it was less effective) - if this had been rushed into treatment, it is more palatable as it is a tablet not chemo etc... where would many women be?
To me the answer is to support personalised medicine research - these guys should be investing in profiling tumors and cross referencing results to determine who it is working for and why.
Just my 2cents worth...
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Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis
June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions
Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
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