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ONT-380/Tucatinib trial? Anybody has contact with Cascadian Therapeutics?
Hello to all.
I am still on Halaven+Herceptin and it is still working for my lung and liver mets. However, my brain mets are stable and I wanted to enter the ONT-380/Tucatinib trial that also targets HER2 brain mets.
On the clinicaltrials.gov site there are more than 60 locations listed but only in the US and Canada. One just opened in UK.
I tried to reach the lab called Cascadian Therapeutics in Seattle to know if they were hoping to open new sites in France or in Europe. I sent a mail on an address that seems more for business development than for patients or doctors and left a message on their answering machine but got no answer.
Is someone on this trial or hoping to enter this trial?
Does anyone know this lab or know how I can contact them?
Thank you for your help!
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08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex
12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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