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Old 07-02-2005, 07:57 AM   #1
lorethia sandoval
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hi, i want to tell you about what i recently learned about.Glutathione.
Glutathion is a protein which is critical to the body and immune system. It acts as an antioxidant, detoxifier and immune system enhancer. antioxidants, agents which protect the body from free radicals, are one of the reasons people have been so excited about taking things like vitamins c and e. but none of these vitamins are natural to your body. you have to obtain them from food source. your body has been supplied with a natural antioxidant glutathione.Gultathione is the body's essential health AID Antioxidant, Immune Booster and Detoxifier. this small protein, produced naturally in the body which maintains these three crucial protective functions. you life depends on glutathione. without it your cells would disintegrate from unrestrained oxidation your body would have little resistance to bacteria, viruses and cancer. and your liver would shrivel up from the eventual accumulation of toxins. Glutathione is not yet a household word. Even doctors who have heard the term may have only a vague idea of it. however, everyone will soon be talking about this critical substance. there was a time when only scientist had heard of cholesterol and vitamins, but today everyone knows about them. now it's Glutathione's turn. The immune system's function is to identify and attack germs and other invaders, including cancer cells. a body with plenty of glutathione fights off these threats more easily by denying most of them a foothold and by confronting the few that get through with an enhanced immune system.elevated glutathione levels enable the body to produce more white blood cells the most important front line defense of the immune system.put simply, glutathione is food for the immune system.our main organ of detoxification is the liver the body's most concentrated source of glutathione. studies show that low glutathione levels lead to poor liver function. causing more and more toxins to circulate through the body and resulting in damage to individual cells and organs.Emergency doctors, toxicologists and lung and liver specialists are well acquainted with glutathione's therapeutic uses. the pharmaceutical drug NAC (n acetyl cysteine) sold under brand names Parlodex and Mucomyst. Pharmaceutical drugs like those mentioned have been used to raise glutathione levels. However, they all produce side effects and are unsuitable for long-term use. the drug NAC is a potent glutathione precursor that has been available for many years and is also found on the shelves of health supplement stores. this pharmaceutical chemical is used to break up mucus in lung disease such as cystic fibrosis, chronic bronchitis and asthma.NAC therapy has two common problems: firstly, it is a pharmaceutical drug and carries a certain toxicity itself. secondly, NAC induced glutathione levels reach a rapid peak and decline within hours.
NAC must be swallowed or injected several times per day and this is very hard on the body.many people taking NAC report symptoms including, rash, wheezing, nausea,vomiting,cramps and diarrhea.a variety of chemical companies package glutathione itself in pill or powder form, but this is not particularly helpful to the body. a small amount of glutathione may make it into the bloodstream, but most glutathione levels in healthy cells make them more resistant to the treatment is lost during the digestive process and cannot effectively raise intracellular glutathione levels.the body's glutathione levels are not raised by eating glutathione. since it is poorly absorbed through the digestive system. it must be manufactured within the cells of the body.glutathione helps us fight cancer in three ways. firstly it can prevent cancers from developing in the first place secondly glutathione tends to combat cancers already established in the body lastly it can alleviate many of the consequences of cancer, weight loss, and the side effects of chemotherapy and radiotherapy.Many types of tumors have large amounts of glutathione. by using the proper precursors or building blocks, glutathione levels can be selectively raised in normal tissues and depleted in cancer cells, making the cancer cells more susceptible to damage and removal by the immune system.
Glutathione helps the immune system by facilitating the growth and function of white blood cells, which are often heavily damaged by the friendly fire of anticancer treatments, and it raises the immune system's capacity to fight the cancer directly.
Glutathione is the body's essential health aid.Glutathione is a small protein found in every cell of the body. it is produced naturally from three amino acids. glycine, glutamine, and cysteine. glutathione is essential to life. Scientists have written over 50,000 articles about glutathione, yet many people are still not aware of its importance to health.most health professionals have only a vague idea of its significance. its importance will soon be widely recognized, because our glutathione level indicates our state of health and how long we will live. this protein naturally produced by the human body, glutathione protects each cell, tissue, and organ from disease, aging and cancer. it is vital to the body, but it can't be synthetically produced.Glutathion's importance to your health cannot be overstated. your immune system is constantly on the prowl for pathogens agents of cellular damage, toxicity and disease. to neutralize them the body needs a ready supply of glutathione. it it doesn't have enough, some of the invaders will get through, infecting the body and or contributing to aging, long-term accumulative damage even cancer.

if you want to learn more about this protein please e-mail



have a great day
lois
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Old 08-14-2005, 01:26 AM   #2
Gina
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Lois,

Do you take the Glutathion, personally, and if so, how to you ingest it?? Can you get it in any food...or does it have to be a supplement. I came across something in my research that might support it working in particularly well for her-2 mediated cancers.. What put you on to it and how much have you personally experimented with it??

Thanks, Gina
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Old 08-19-2005, 07:37 PM   #3
Tom
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Dear Lois,

Thanks for the extensive post on glutathione. It is my understanding from hundreds of hours of reading, that one way to selectively lower glutathione levels in malignant cells, is by a process known as feedback inhibition. Theory holds that by the intake of whey protein isolate, the malignant cells will begin to naturally produce less glutathione. The body's normal cells continue to function properly as they use the precursor amino acids supplied by, among other things, the glutamine from the whey protein isolate.

Additionally, the whey protein isolate, being so bioavailable to the body's cells, will act to counter the effects of catabolic wasting (cachexia) in those whose digestive processes have been disrupted by the cancer. I will look for some of my research and post some of it later on this site.

Best Wishes,
Tom
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Old 08-20-2005, 06:15 AM   #4
Janet/FL
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I am posting two studies below. My alternative medical doctor, a nurologist, wants me to take it and I am inquiring if my oncologist will do so. It is give IV.
Janet

1st study

http://www.ncbi.nlm.nih.gov/entrez/query.f...4&dopt=Abstract

Peripheral neurotoxicity following high-dose cisplatin with glutathione: clinical and neurophysiological assessment.

Pirovano C, Balzarini A, Bohm S, Oriana S, Spatti GB, Zunino F.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.

The use of high-dose cisplatin is limited by development of severe peripheral neurotoxicity and gradual worsening of renal function. In an ongoing study of high-dose cisplatin glutathione has been employed with the aim of preventing major cisplatin-induced toxicities. Neurotoxicity was examined in detail in 32 patients with ovarian cancer treated with cisplatin (160 mg/m2) and cyclophosphamide (600 mg/m2) every 3-4 weeks for five courses. In addition to serial complete neurological examination, sensory action potentials (SAPs) and motor conduction velocities (MCVs) were also assessed. We confirmed the development of a predominant sensory involvement, characterized by mild distal paresthesias and decrease in vibratory sensibility and in deep tendon reflexes, with a slight reduction of SAPs, observed after three courses of treatment. After five courses, distal paresthesias and disesthesias, decreased proprioception and loss of vibratory sensibility with ataxic signs, absence of deep tendon reflexes, unobtainable SAPs and only moderately reduced MCVs were seen. We did not observe any case of disabling neuropathy. There was a tendency to a more severe involvement of peripheral nerves in patients aged more than fifty. The 3 patients presenting the most serious neuropathy were the oldest in the whole group. Low degree of neurotoxicity observed in this study supports a glutathione protection against cisplatin-induced neurotoxicity. As the urinary excretion of platinum indicated no changes in the renal clearance of cisplatin following repeated courses, the lack of drug accumulation and high plasma peak due to preserved renal function might explain the reduced neurotoxicity observed.

PMID: 1334604 [PubMed - indexed for MEDLINE]

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Old 08-20-2005, 06:19 AM   #5
Janet/FL
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Second study

http://www.jco.org/cgi/content/abstract/13/1/26

Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial
S Cascinu, L Cordella, E Del Ferro, M Fronzoni and G Catalano
Servizio di Oncologia, Ospedali Riuniti, Pesaro, Italy.

PURPOSE: We performed a randomized double-blind placebo-controlled trial to assess the efficacy of glutathione (GSH) in the prevention of cisplatin (CDDP)-induced neurotoxicity. PATIENTS AND METHODS: Fifty patients with advanced gastric cancer treated with a weekly CDDP-based regimen were included in this study. In patients randomized to receive GSH, GSH was given at a dose of 1.5 g/m2 in 100 mL of normal saline solution over a 15-minute period immediately before CDDP administration, and at a dose of 600 mg by intramuscular injection on days 2 to 5. Normal saline solution was administered to placebo- randomized patients. Clinical neurologic evaluation and electrophysiologic investigations have been performed at baseline and after 9 (CDDP dose, 360 mg/m2) and 15 (CDDP dose, 600 mg/m2) weeks of treatment. RESULTS: At the 9th week, no patients showed clinically evident neuropathy in the GSH arm, whereas 16 patients in the placebo arm did. After the 15th week, four of 24 assessable patients in the GSH arm suffered from neurotoxicity versus 16 of 18 in the placebo arm (P = .0001). In confirmation of this neuroprotective effect, the neurophisiologic investigations, based on the evaluation of the median, ulnar, and sural sensory nerve conduction, showed a statistically significant reduction of these values in the placebo arm but not in the GSH arm, above all considering potential amplitude. In this trial, GSH also reduced hemotransfusion requirements (32 v 62 hemotransfusions) and treatment delay (55 v 94 weeks). The response rate was 76% (20% complete response) in the GSH group and 52% (12% complete response) in the placebo arm, confirming preliminary reports about the lack of reduction in activity of cytotoxic drugs induced by GSH. CONCLUSION: This study provides evidence that GSH is a promising and effective new drug for the prevention of CDDP-induced neuropathy, and that it does not reduce the clinical activity of chemotherapeutic drugs.
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Old 08-21-2005, 12:00 AM   #6
Gina
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Thanks to all who wrote in on this thread..., this could be a big missing piece of some of my research puzzle that really is starting to make the whole big "picture" come into focus. If folks are interested, lets continue this glutathione thread and as soon as I can write something up how it fits in with other research I already have, I will share it with you.

Again, can not thank you enough....let's keep pursuing this one, it could be REALLY useful--GINA
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Old 11-19-2005, 09:55 PM   #7
CherylS
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How do we get healthy supplement of glutathione?

If the NAC products are hard on the body as stated above, and plain glutathione oral supplements aren't absorbed, what do we do boost our levels?
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Old 11-21-2005, 11:05 AM   #8
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Sources - more information

Here are two links that may help.



http://www.1whey2health.com/food-sou...lutathione.htm

http://www.1whey2health.com/food-sou...lutathione.htm

Whey protein is suggested to be helpful to cancer sufferers in trials I have seen reported see AnnieAppleseed Project web site.

ALA Alphe Linoleic Acid the omega three source for the eicosanoid pathway (see posts on articles of interest section)

RB
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