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Old 05-18-2012, 09:00 PM   #1
Lani
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Join Date: Mar 2006
Posts: 4,778
trial results to look out for

.Ongoing randomized phase III trials in human epidermal growth factor receptor 2 overexpressing metastatic breast cancer.

Clinical trial
NEFERTT
(N = 1200)
First-line metastatic
BO22589
(N = 1092)
First-line metastatic
EMILIA
(N = 580)
Locally advanced or metastatic
PHEREXA
(N = 450) Second-line after trastuzumab
BOLERO-1
(N = 717)
First-line metastatic
BOLERO-3 (N = 572) Resistant to trastuzumab
Study arms
Neratinib + Paclitaxel Trastuzumab + Paclitaxel
Herceptin + taxane T-DM1
T-DM1 + pertuzumab
T-DM1
Capecitabine + lapatinib
Docetaxel + trastuzumab + pertuzumab
Capecitabine + trastuzumab Capecitabine + trastuzumab +
Pertuzumab
Pertuzumab + trastuzumab Pertuzumab + trastuzumab + everolimus
Vinorelbine + trastuzumab Vinorelbine + trastuzumab +
everolimus

Trial endpoint/ WHEN Data expected:
PFS, OS 2012
PFS 2012
PFS, OS, ORR 2013
PFS, TTP, TTF, ORR, CBR 2015
PFS, OS, ORR, CBR, TTR 2012
PFS, OS, ORR, CBR 2012
CBR, clinical benefit rate; ORR, overall response rate; OS, overall survival; PFS, progression-free survival; TTF, time to treatment failure; TTP, time to progression; TTR, time in treatment range.
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Old 05-20-2012, 10:33 PM   #2
radiant
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Posts: 88
Re: trial results to look out for

Bless you Lani, as usual!!
__________________
------------------------------
Dx Stage 3C 2005, triple +, tons of lymph nodes as well. FEC, surgery, TCH, rads, herceptin 1 year. And, Aromasin.
2007 - recurrence to medistinal lymph node, Abraxene and Herceptin - took it down 50%
2008 - on Arimidex/Herceptin - stable lymph node.
2009 - stable on Arimidex/Herceptin
2010 - lymph node progression and liver mets.
2010 - went on Gemzar, Navelbine, Herceptin - Navelbine and Herceptin took liver mets down. lymph node slightly progressed.
2010 - did Xeloda & Tykerb - MAJOR progression in liver in only 6 weeks.
Dec 2010 - present - Ixempra/Avastin/Herceptin/Fasoldex - regressing
June 2012 - chemo break
Sept 19, 2012 - start t-dm1. Chose this over going back on Ixempra.
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Old 05-21-2012, 08:34 PM   #3
anna4969
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Re: trial results to look out for

Lani

thank you for keeping us so very informed. Have you heard anything about the Hera trial, whether 2 years is better than on year of Herceptin?

thank you
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Old 05-22-2012, 01:17 AM   #4
Lani
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Re: trial results to look out for

nothing on the 2yr vs 1 yr hera results yet
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Old 05-22-2012, 05:22 AM   #5
anna4969
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Re: trial results to look out for

Thanks Lani

Just saw onc yesterday and we were discussing it again and when we thought those results were going to be reported on.

I appreciate your diligence.
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Old 05-22-2012, 01:06 PM   #6
Becky
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Re: trial results to look out for

Lani

Do you think they will ever publish the one year versus two year HERA study results?
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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