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Old 04-04-2012, 07:20 PM   #1
'lizbeth
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Numerous Vaccine Trials

http://www.clinicaltrials.gov/ct2/re...cine&recr=Open


Wow, I am surprised at the number of vaccine trials. If you are interested please contact one of the trial administrators for more information.

A clinical trial is something you can enroll in on your own, you don't need to wait on your oncologist. However, it is great to have their guidance and support.
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Diagnosed 2007
Stage IIb Invasive Ductal Carcinoma, Pagets, 3 of 15 positive nodes

Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"

Additional treatments:
GP2 vaccine, San Antonio Med Ctr
Prescriptive Exercise for Cancer Patients
ENERGY Study, UCSD La Jolla

Reconstruction: TRAM flap, partial loss, Revision

The content of my posts are meant for informational purposes only. The medical information is intended for general information only and should not be used in any way to diagnose, treat, cure, or prevent disease
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Old 05-09-2012, 03:48 PM   #2
babysandpiper
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Re: Numerous Vaccine Trials

I was blessed to be invited and able to participate recently in one of the Her2+ vaccine w/adjuvent trials in the link 'lizbeth provided. This Trial is an exciting and ongoing Phase I/II study at the University of Washington in Seattle, Wa called:

Ampligen w/Vaccine Therapy for Stage II-IV HER2-Positive Breast Cancer
Phase I-II Study of HER2 Vaccination with poly(I) Poly(C12U) (Ampligen) as an Adjuvant in Optimally Treated Breast Cancer Patients

The results of my trial will be available to me in about a month, to let me know whether my immune system generated a response to the particular dose of Ampligen I was randomly assigned to along with the Her2 Vaccine. I am hoping my immune system generated a response, but even more, I am just happy and excited to have been able to participate and be a part of something that might help ladies down the road, much in the way that ladies who came before me, especially those who paved the way in trials of Herceptin, helped me!

"This randomized phase I/II trial studies the side effects and best dose of Ampligen when given together with vaccine therapy and sargramostim (GM-CSF) to see how well it works in treating patients with stage II-IV human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Vaccines made from synthetic HER2/neu peptides may help the body build an effective immune response to kill tumor cells that express HER-2/neu. Our group has developed vaccines against the HER2 protein that create immune responses and in this study we are researching different ways that we may be able to make that immune response even better. Adjuvants are one way to help vaccines produce stronger immune responses. Our group has typically used the adjuvant GM-CSF and in this study we would like to look at another adjuvant called Ampligen. Giving vaccine therapy together with Ampligen and/or GM-CSF may be an effective treatment for breast cancer."

For more details and to see if you qualify for this particular trial click on the links below.

http://www.seattlecca.org/clinical-t...CT01355393.cfm

http://www.clinicaltrials.gov/ct2/sh...cr=Open&rank=2
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Old 05-09-2012, 08:31 PM   #3
'lizbeth
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Re: Numerous Vaccine Trials

Where's the like button?
__________________
Diagnosed 2007
Stage IIb Invasive Ductal Carcinoma, Pagets, 3 of 15 positive nodes

Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"

Additional treatments:
GP2 vaccine, San Antonio Med Ctr
Prescriptive Exercise for Cancer Patients
ENERGY Study, UCSD La Jolla

Reconstruction: TRAM flap, partial loss, Revision

The content of my posts are meant for informational purposes only. The medical information is intended for general information only and should not be used in any way to diagnose, treat, cure, or prevent disease
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Old 05-09-2012, 09:26 PM   #4
StephN
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Wink Re: Numerous Vaccine Trials

I took part in the same vaccine trial as Babysandpiper. Like her I am waiting to hear about my immune response.

They did tell me I got one of the higher doses of the Ampligen, so that much I do know. And I did notice an uptick in my energy and mental ability.

I was in the Phase I portion.
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"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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Old 05-10-2012, 07:38 AM   #5
babysandpiper
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Re: Numerous Vaccine Trials

Hi StephN! It's exciting to see that someone here also participated in the same Phase I trial as me! My dosing of Ampligen turned out to be the lowest amount (dang!), but the nurse said that in the mouse model, all doses (even the low ones) showed some immune response. So I'm hopeful! I could have waited to be in the Phase 2 part of the trial, but I wanted to get the show on the road so to speak!

I lived in Seattle for 25 years and have recently moved out on the coast, near the ocean and rain forest. I still enjoy getting up to Seattle to visit friends, family, and oncology followups!
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Old 09-13-2012, 01:46 PM   #6
MizMarie
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Re: Numerous Vaccine Trials

I just learned about this trial - I emailed the coordinator, and was sent the study information and release forms to complete. They are wrapping up Phase I, and I was told they will contact me when they are ready to start enrollment into Phase II. It's encouraging to know that this kind of research is going on, and exciting to think of being able to help out (and maybe help myself).
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