HonCode

Go Back   HER2 Support Group Forums > Clinical Trials
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 03-09-2011, 07:26 PM   #21
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

Lorraines story should air tomorrow night ( Thurs, ) ch. 5 boston, at 11. bostonchannel.com. Hope it goes national.
phil is offline   Reply With Quote
Old 03-10-2011, 04:55 AM   #22
Chelee
Senior Member
 
Chelee's Avatar
 
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
Re: Access to T DM-1

Hi Phil,
I look forward to reading Lorraine's story. Thank goodness for the internet...this way we don't miss much. I still can't thank you two enough for all the hard work to help spread the word about T-DM1. When you have time keep us updated on Lorraine. You two take care.

Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
Chelee is offline   Reply With Quote
Old 03-11-2011, 06:30 PM   #23
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

Check outLorraines' story on bostonchannel.com, Search :
" heidke-mccartin". Lorraine was awesome, I'm so proud of her. You can see how well shes doing. Living proof that this FDA Admin. is botching up the approval process. Cant keep pace with the new drugs. And Kelley Tuthill did agreat job helping us feel at ease, and putting the story together. Lets keep up the pressure !
phil is offline   Reply With Quote
Old 03-11-2011, 11:25 PM   #24
Chelee
Senior Member
 
Chelee's Avatar
 
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
Re: Access to T DM-1

Phil,
Excellent job getting your story across. You even managed to get John Kerry to fire off a letter. This whole T-DM1 issue is so infuriating to me. Especially for us stage IV women.

This link below will take you to Lorraine's story for those that want to see it. It's well worth it...great job!

http://www.thebostonchannel.com/health/27150551/detail.html

Here's to Lorraine becoming NED thanks to T-DM1.

Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
Chelee is offline   Reply With Quote
Old 03-12-2011, 06:50 AM   #25
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

Those of you who live in the DC or NY area, call your local TV, newspapers, ask for the health editors e-mail. Send them the story.
phil is offline   Reply With Quote
Old 03-12-2011, 04:28 PM   #26
Chelee
Senior Member
 
Chelee's Avatar
 
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
Re: Access to T DM-1

Phil,
I don't live in the NY or DC area...but I still like the idea of calling my newspaper. I use to work for them yrs ago. It might be worth it to tell them about your story, along with my own troubles and opinions on this T-DM1 issue. Maybe I can get their attention? It's worth a try. Thanks for your idea.


Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
Chelee is offline   Reply With Quote
Old 03-13-2011, 08:36 AM   #27
schoonder
Senior Member
 
Join Date: Jul 2008
Posts: 186
Re: Access to T DM-1


When FDA approved Tykerb/Xeloda protocol for MBC it changed landscape of available treatments.
At that time Genentech readily and willingly discontinued T-DM1 Her2+ 3rd line phase II trial that started in 7/07 and after implementing necessary alterations to account for this change, began a new evaluation (7/08). Yes, net result for pertinent MBC patients was a program delay of one year, but those are the rules, data presented to FDA must include latest treatment options for that disease. A possible benefit from conducting this second phase II is that FDA and Genentech had opportunity to sample results for not only a longer period of time, but also examine a much larger candidate population then they originally intended for this what was hoped to become a fast-track program.
So where are Genentech and FDA now? Well from Her2+ 3rd line MBC perspective they are at a two plus year standoff, because FDA refuses to evaluate the supplied data and Genentech isn’t willing to correct shortcomings identified by FDA for this particular trial. By mid-2012 company hopes to submit a new set of data from a currently worldwide ongoing trial in 2nd line Her2+ MBC (Emilia) and by doing this they also hope to receive approval in 3rd line setting.
This sums it up between Genentech and FDA, but where does this leave the thousands of patients that currently are identified being 3rd line Her2+ MBC, the ones that are so desperately in need of new, effective and easy to tolerate drugs? It looks like that patient population will be left carrying the bag. Usually in a standoff between parties they continue to get together to get differences resolved, when that after some finite period of time fails and subject matter is deemed of sufficient importance, arbitrators are assigned to bring matters to a fair conclusion.
Well, there are no continued talks, no arbitrators, guess subject matter isn't important, let’s do nothing, pull the rug out from under these sick people, let’s not give them opportunity to benefit from a potentially efficacious drug, let’s just remove all hope. Maybe this is could be conceived as a cruel and unusual punishment, but these patients are not criminals, so the 8th amendment of the U.S. Constitution doesn’t apply to them. Case is shut.
schoonder is offline   Reply With Quote
Old 03-13-2011, 10:50 AM   #28
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

Thanks chelee. Anyone contacting media should mention that Gen. is keeping access from NY, Boston, the whole Northeast.
Schoonder, the FDA and Gen. are talking, taking their sweet time, but they are talking. We must keep up the pressure.
phil is offline   Reply With Quote
Old 07-25-2011, 06:30 PM   #29
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

genentech announced that they are closing the access program as of Sept. 6. Those already in it will be grandfathered in. They didnt say it, but its related to this FDA's fumbling of the development of t dm-1, a life-saving tx. A drug w/ the best stats coming out of Phase II trials , since Herceptin itself, 15 yrs before. This FDA denies approval of t dm-1 last Sept., recommending 3 more yrs of study, and approves Halaven the same month, a drug w/ much, much less impressive stats. I have nothing against halaven, but this FDA is burying its head in paperwork, refusing to see whats on tv. " Living Proof " , scores of women like Lorraine.Making us jump through more hoops, now its their new mantra , " Overall Survival ".
As research gets closer to winning the war on breast cancer , this FDA is losing it. Speak up !!
phil is offline   Reply With Quote
Old 07-25-2011, 06:56 PM   #30
Jackie07
Senior Member
 
Jackie07's Avatar
 
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,801
Re: Access to T DM-1

Chrisy has posted detailed information on this thread:

http://her2support.org/vbulletin/showthread.php?t=50864
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016

"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe
Jackie07 is offline   Reply With Quote
Old 07-25-2011, 07:01 PM   #31
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

Important addendum. Gen. is adding a large new trial to try to satisfy this FDA 's new focus on " Overall Survival ",( I call it " Slow As Usual "), at 42 sites, comparing t dm-1 to other txs. None of this should have happened, if ever adrug deserved accelerated approval, it was this drug. Starting in 2010, this FDA began slowing down the process, just as this breakthrough drug was ready.
They refused to see what they had already pre-determined they would not see. Interesting that they began the process of revoking Avastins approval at the same time .
They need to be fixed from above. This is President Obamas FDA, and this Congress's FDA. Make sure you let your reps, and the Congressional " HELP" Committee know how you feel about this FDA. Once they know, then they own it. Its theirs. In an election year. 46,00 women and men will die fron breast cancer this year, and this FDA is slower, more contradictory than ever...
phil is offline   Reply With Quote
Old 08-01-2011, 12:49 PM   #32
schoonder
Senior Member
 
Join Date: Jul 2008
Posts: 186
Re: Access to T DM-1

Latest update on wider T-DM1 access.
http://assertivecancerpatient.com/2011/08/index.html
schoonder is offline   Reply With Quote
Old 08-26-2011, 12:43 PM   #33
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

Lorraine got a call from the research clinic in Va. They have started the process of transferring her T DM-1 Access to Dana Farber in Boston ! We are very, very excited !!
Any woman in the Access Program, traveling long distances to get T DM-1, should contact your site , to ask about transferring to a site closer to home. Make sure the site has started the transfer process. The sooner you dont have to travel , the better.
Any woman w/ Her2 illness that has progressed on taxanes, and tyk/ xel, ( or intolerable s/e w/ tyk./ xel ) can still enroll in Access by Sept 6th. After that a new trial ( Theresa) will be starting, but the start date is un-clear. And any trial will have more regs thatn Access , like a 30day wash-out vs. 2 weeks.
Contact Genentech Access Solutions w/ any ? about the above info.
phil is offline   Reply With Quote
Old 08-26-2011, 03:00 PM   #34
StephN
Senior Member
 
StephN's Avatar
 
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,073
Re: Access to T DM-1

WOW, Phil! I am jumping for joy right along with you and Lorraine. Thanks for letting us know that your long and intrepid work is paying off.

I am also so happy that the drug has done such good for your dear wife.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
StephN is offline   Reply With Quote
Old 09-16-2011, 01:18 PM   #35
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Access to T DM-1

Please support our petition to Dr. Sebelius, asking her to investigate this FDA's denial of Herceptin T DM-1 to Stage IV Survivors. She is this FDAs boss. Go to the link below, study up on the issue, send the word out !
http//signon.org/sign/fda-blocks-life-saving?source=c.url&r-by=60340
phil is offline   Reply With Quote
Old 09-16-2011, 05:19 PM   #36
schoonder
Senior Member
 
Join Date: Jul 2008
Posts: 186
Re: Access to T DM-1

Phil
Link didn't work for me.
schoonder is offline   Reply With Quote
Old 09-16-2011, 08:35 PM   #37
rhondalea
Senior Member
 
rhondalea's Avatar
 
Join Date: Jun 2011
Location: Somerset, NJ
Posts: 485
Re: Access to T DM-1

The link is missing a colon. It should be:

http://signon.org/sign/fda-blocks-li...url&r-by=60340

rl
__________________

2/6/09 Core needle biopsy: negative; Mammos through 2010: no change
3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much
4/14/11 Core needle biopsy: negative for cancer
5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5
6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3
7/14/11 CT/Bone scans NED; MUGA 66%
7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11
9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64%
9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012
12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy!
2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17
5/16/12 Start five-years Metformin trial
6/19/12 MUGA 61%
8/21/12 Brain MRI NED (head still hurts, brain still fogged)
9/4/12 Herceptin done!
9/6/12 Port out!
7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013
5/2014 Add Namenda 7mg
9/2014 Stop Aricept and Namenda; Neuropsychological evaluation
10/24/14 Start cognitive rehabilitation therapy
rhondalea is offline   Reply With Quote
Old 09-17-2011, 07:46 AM   #38
Jackie07
Senior Member
 
Jackie07's Avatar
 
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,801
Re: Access to T DM-1

Newest information posted by Brenda on the Her2 Board:

UPDATE as of today, 9/16/2011, from Genentech:

Genentech would like to provide an update on the protocol amendment to the T-DM1 patient access study (called T-PAS or TDM4884g) that may allow some patients enrolled in the study to receive T-DM1 closer to their homes. We submitted the proposed amendment to the FDA on August 8, 2011, and have received no questions or concerns to date that would require re-evaluation or revision. As a result, we are proceeding with this amendment. All of the study sites involved have been informed, and the next step is for each site to approve and implement it within their own institutions.

The T-PAS protocol amendment provides T-PAS patients the option to enroll into another, ongoing Genentech/Roche study (called the “extension study” or TDM4529g), which, in essence, doubles the number of sites and locations where T-PAS patients can receive T-DM1.. This option is only available to patients currently enrolled in T-PAS. Transferring to one of the extension study sites is optional and available to patients who have completed at least six cycles (18 weeks) of treatment, are determined stable by their doctor (i.e., not progressing and tolerating T-DM1 without major side effects) and meet other required criteria for the TDM4529g study. Current T-PAS patients interested in receiving T-DM1 at a site closer to home should contact the T-PAS study coordinator at their current site. The study coordinator can help determine if one of the extension study sites is closer and begin the transfer process to the new site. Since the amendment requires IRB approval at each of the original T-PAS and extension study sites, some sites may be able to accommodate the transfer of T-PAS patients more quickly than others.

People not enrolled in T-PAS but still interested in T-DM1 should talk to their doctor about their eligibility for the other T-DM1 studies currently enrolling patients.

__________________
Brenda
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016

"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe

Last edited by Jackie07; 09-17-2011 at 07:53 AM..
Jackie07 is offline   Reply With Quote
Old 09-18-2011, 04:54 PM   #39
annmask
Senior Member
 
Join Date: Sep 2010
Location: New hampshire
Posts: 44
Re: Access to T DM-1

Hi Phil,

I find this site hard to use.....looks like maybe you added this to the existing TDM thread.....I had a hard time finding it, and tried post it myself. It still seems hard to locate and it seems that this site should have about everyone signing if they know about it!
annmask is offline   Reply With Quote
Old 09-18-2011, 09:52 PM   #40
ElaineM
Senior Member
 
ElaineM's Avatar
 
Join Date: May 2006
Posts: 3,142
Wink Re: Access to T DM-1

Thanks for your efforts Phil. I signed the petition and sent the link to a few other people and asked them to consider signing it too. Even if your efforts are not successful I appreciate the effort you put into this project. You did it for your wife. You also did it for everyone else. That is great !!
By the way, Annmask it is not absolutely neccessary to share alot of details if doing so proves to be difficult or if you don't wish to share some details with everyone. Many of us don't share alot of details. You could do what I did (see below) or post the information you wish to share with us somewhere else and post a link to it in your account. Participation is what is important around here. You did just fine with your post in the other thread.
Take care everyone.
__________________
Peace,
ElaineM
12 years and counting
http://her2support.org/vbulletin/showthread.php?t=48247
Lucky 13 !! I hope so !!!!!!
http://her2support.org/vbulletin/showthread.php?t=52807
14 Year Survivor
http://her2support.org/vbulletin/showthread.php?t=57053
"You never know how strong you are until being strong is the only choice you have." author unknown
Shared by a multiple myeloma survivor.

Last edited by ElaineM; 09-18-2011 at 10:09 PM.. Reason: editing
ElaineM is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -7. The time now is 01:08 PM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2018, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007
free webpage hit counter