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Old 07-19-2011, 01:13 PM   #21
KristinSchwick
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Join Date: Jun 2011
Location: Iowa
Posts: 231
Re: Herceptin and CA 27.29 tumor marker

Hi all,
The Ca 27.29 test is not used to diagnose metastases, rather it is used after met disease has been documented and the docs need some way to determine whether the met. cancer is growing or shrinking.

Cancer does not just lie quiet, it grows, often very aggressively. Therefore unless your Ca27.29 numbers are increasing consistently or may be over 40, you shouldn't worry. The Ca27.29 test looks for the over abundance of a normal non cancerous protein, Muc1. Muc1 is often shed by breast cancer cells when they are rapidly growing. The presence of high Muc1 levels DOES NOT necessarily mean you have cancer or even met. cancer, however if you have other symptoms/tests- ie: pain, elevated liver enzymes, etc, then your doctor might have an idea of what maybe going on. As always, cancer can only be diagnosed by biopsies or high tech imaging.

For me personally, I never had Ca27.29 testing until I had a bone scan that showed bone mets in my back, which had been hurting for 2 weeks. When they tested it, the value was 99. Since that time, the numbers have fallen with my treatment, 76 and the 45.

Hope that clears things up and lessens the worries.
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[B]Kristin
Aug 2010: diagnosed stage 3b, 4 mo. after birth of son. 29 yrs old and breastfeeding, ER/PR-, Her-2+ started Neoadjuvant therapy: 4x FEC, 10x abraxane & Herceptin
Feb 2011: L mx with recon. Path. showed only DCIS but 4/10+ nodes.
March 2011: 6 wks rads.
Mother passed, lower back pain.
Late May 2011: Bone mets but organs clear; Tykerb, Xeloda, Xgeva. Stopped Herceptin. Implant infected: removed implant.
October 2011: Bone progression; Gemzar and Carboplatin & restarted Herceptin.
Jan 2012: Progression, re-classified as ER+; Tykerb, Herceptin, Zoladex & Femara. Anti-E is working!
May 2012: ovaries out, markers stable but elevated. Cont. Herceptin, Tykerb, Xgeva & Femara.
Dec 2012: aromasin
Jan 2013: faslodex, herceptin, tykerb
Jun: Kadcyla
Aug: Rads to hip, then Perjeta, Herceptin & Taxotere
Nov 2013: Perjeta, Herceptin, Halaven
Early 2014: Affinitor, Aromasin, Perjeta, Herceptin.
June 2014: Estradiol, Perjeta, Herceptin
Aug 14: Tamoxofin, H & P
http://kristin-notdying-blog.blogspot.com/
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Old 07-19-2011, 06:55 PM   #22
weety
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Join Date: Dec 2009
Posts: 56
Re: Herceptin and CA 27.29 tumor marker

Thanks for sharing your experience with the tumor markers. Congrats that they are going down!!!
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Diagnosed 7/09 with 7mm IDC ER weakly +, PR -, Her2+

TCH chemo 8/09-12/09

Ooph/hysterectomy 4/10

Started Femara 6/10

Completed year of herceptin 10/11

Zometa 1/11 (2X/yr for 2yrs)

Hopefully nothing else!!!!
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